Clinical and molecular characterization of POU3F4 mutations in multiple DFNX2 Chinese families.

Background: Many X-linked non-syndromic hearing loss (HL) cases are caused by various mutations in the POU domain class 3 transcription factor 4 (POU3F4) gene. This study aimed to identify allelic variants of this gene in two Chinese families displaying X-linked inheritance deafness-2 (DFNX2) and one sporadic case with indefinite inheritance pattern.

Methods: Direct DNA sequencing of the POU3F4 gene was performed in these families and in 100 Chinese individuals with normal hearing.

[Clinical analysis and prevention of complications associated with ultrasound-guided percutaneous thick needle biopsy].

Objective: To investigate the occurrence of complications in US-guided percutaneous biopsy using core (>19G) gauge cutting needle.

Methods: A retrospective analysis of 5366 US-guided thick needle biopsies was conducted to analyze the incidence of complications after biopsy at different positions.

Results: The total incidence of complications was 1.