Publications by authors named "Jing-Ning Huang"
Neurofibromatosis type 1 (NF1) is a dominant hereditary disease characterized by the mutation of the gene, affecting 1/3000 individuals worldwide. Most NF1 patients are predisposed to benign peripheral nerve sheath tumors (PNSTs), including cutaneous neurofibromas (CNFs) and plexiform neurofibromas (PNFs). However, 5%-10% of PNFs will ultimately develop into malignant peripheral nerve sheath tumors (MPNSTs), which have a poor prognosis.
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- The study investigated the impact of different molecular weights of inhaled heparins on T helper cell differentiation in a mite allergy model using BALB/c mice.
- Mice were divided into four groups: a control group, a mite sensitized group, and two heparin-treated groups (regular and low molecular weight), with various tests conducted to analyze immune responses.
- Results showed that both heparin treatments significantly reduced serum IgE levels and decreased the expression of key immune markers in the spleen compared to the mite sensitized group, suggesting potential therapeutic effects worth exploring further.
A functional single-chain Fv antibody fragment (scFv) specific for acidic isoferritin (AIF) was produced at high level in Escherichia coli. The variable regions of heavy chain (V(H)) and light chain (V(L)) from the hybridoma 4c9 were connected with a flexible linker using an assembly polymerase chain reaction. The construct of V(H)-linker-V(L) was inserted into a phagemid pCANTAB 5 E followed by selection with the Recombinant Phage Antibody System (RPAS).
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