Th1 cell immune response in infection with anti-interferon-γ autoantibody syndrome.

Anti-interferon-γ autoantibody (AIGA) syndrome may be the basis of disseminated infection in human immunodeficiency virus (HIV)-negative adults. However, the pathogenesis of Th1 cell immunity in infection with AIGA syndrome is unknown. A multicenter study of HIV-negative individuals with infection was conducted between September 2018 and September 2020 in Guangdong and Guangxi, China.

Serum sphingolipids aid in diagnosing adult HIV-negative patients with pulmonary cryptococcosis: a clinical cohort study.

Background: Pulmonary cryptococcosis (PC) contributes to the ongoing global disease burden in human immunodeficiency virus (HIV)-negative populations. Since some PC patients are misdiagnosed under existing diagnostic guidelines, new diagnostic markers are needed to improve diagnostic accuracy and therapeutic efficacy and reduce disease risk.

Methods: Our previously established sphingolipidomic approach was employed to explore the use of serum sphingolipids (SPLs) in diagnosing HIV-negative patients with PC.

[Involvement of heme oxygenase in PM2.5-toxicity in human umbilical vein endothelial cells].

Objective: To investigate the involvement of heme oxygenase (HO-1) in PM2.5 induced toxic responses in human umbilical vein endothelial cells (HUVECs).

Methods: The experiment groups are as follows: (1) control group; (2) PM2.