Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response.

Purpose: Cyclophilin A (CypA) inhibits CD4 T cell signal transduction via interleukin-2-inducible T-cell kinase (Itk), a tyrosine kinase required for T helper (Th) 2 cells function. Furthermore, mice with CypA silencing developed allergic diseases associated with increased Th2 cytokines production. CD4 T cells with a Th2-cytokine pattern have been demonstrated to have a pivotal role in the pathogenesis of asthma.