Publications by authors named "Jing-Kun Lu"

Article Synopsis
  • Human β-defensin-1 (hBD-1) may help the immune system fight colorectal cancer by influencing the mTOR pathway and promoting autophagy in colon cancer cells (SW620).
  • In experiments, hBD-1 reduced the growth of SW620 cells and showed a decrease in mTOR activity while increasing proteins associated with autophagy (Beclin1 and LC3II/I).
  • Bioinformatics analysis identified seven lncRNAs linked to the mTOR pathway, with TCONS_00014506 being particularly important; inhibiting this lncRNA further enhanced hBD-1's effects on mTOR and autophagy.
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Sanwei-Tanxiang powder (SWTX), a traditional Mongolian and Tibetan medicine containing a cocktail of active molecules, relieves angina pectoris and improves recovery in patients with coronary heart disease (CHD). The pharmacological effect of SWTX on CHD was analyzed at a systemic point of view in our previous studies. The bioinformatics prediction showed that the PI3K/Akt/FoxO3a pathway was one of important pathways of SWTX on treatment of coronary heart disease.

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Objective: This study aimed to evaluate the therapeutic effects of potato extract (PE) on cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD).

Methods: PE was first prepared by frozen centrifugation, and its amino acid composition was detected. Toxicity of PE was analyzed by changes in morphology, behavior, routine blood indexes, and biochemical criteria of mice.

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The effects of effective part group on hyperlipidemia in animal were studied. The SD rats, hamsters and Kunming mouse were divided into blank group, model group. The positive control group and test group were fed with normal diet, blank and other groups were fed with high fat diet (mouse only a single intraperitoneal injection of egg yolk ).

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