Alkaloids and lignans isolated from Alisma orientale exhibit anti-pulmonary fibrosis activities by modulating an apoptotic signaling pathway.

From the tuber of Alisma orientale (Sam.) Juzep. (Alismataceae), twenty-four compounds were isolated, including six (1, 2, 3, 10, 14, and 17) that were not yet characterized.

Epimesatines P-S: Four Undescribed Flavonoids from Maxim. and Their Cytotoxicity Activities.

In this study, four previously undescribed flavonoids, named epimesatines P (), Q (), R (), and S (), were isolated from the aerial parts of Maxim. Their structures and absolute configurations were confirmed via spectroscopic analyses, quantum chemical electronic circular dichroism (ECD) calculations, Mo(OAc)-induced ECD, and Rh(OCOCF)-induced ECD experiments. Epimesatines Q and R were characterized by the presence of furan rings.

Two new flavonoid thioglucosides from the seeds of .

Two previously undescribed flavonoid thioglucosides lepidiumflavonosides A and B () and two known megastigmane compounds (7,9)-9-hydroxy-5,7-megastigmadien-4-one 9-O--D-glucopyranoside () and (9)-4-oxo--inol -D-glucopyranoside () were isolated from the water extract of the seeds of Willd. The structural elucidation of isolated compounds was unambiguously determined based on extensive 1D and 2D NMR spectroscopic analyses. All compounds were evaluated for their estrogen-like effects on MCF-7 cells in .

Alkaloids from the stem of .

Two new cyclotrypyamine alkaloids equisetinines A and B, as well as three known alkaloids () were isolated from the stems of Bunge. Their structures were characterized by spectroscopic methods, and the absolute configurations of the new compounds were determined by interpretation of their electronic circular dichroism. Anti-asthmatic activities of compounds were evaluated by releasing -Hex in C48/80-induced RBL-2H3 cells, and compound exhibited significant anti-asthmatic activities.

Lignans and terpenoids from the stem of Ephedra equisetina Bunge.

Seven undescribed lignans, equiselignan A-F, and six undescribed terpenoids, equiseterpenoid A-E (including two pairs of enantiomers, (+/-)-equiselignan A and (+/-)-equiseterpenoid E), were isolated from the stems of Ephedra equisetina Bunge. Their structures were elucidated by spectroscopic methods, and the absolute configurations of the undescribed compounds were determined by interpretation of their electronic circular dichroic (ECD) and optical rotation data. In β-hexosaminidase (β-Hex) release assay, anti-asthmatic activities of all of the compounds were evaluated by releasing β-Hex in C48/80-induced RBL-2H3 cells.

Four -geranyl flavonoids from the flowers of and their anti-inflammatory activity.

Four new -geranyl flavonoids, paulownione D-G (-) were isolated from the 50% acetone-HO extract of the flowers of The structures of the compounds were determined by extensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR). All of the compounds (-) exhibited potent protection effects in H9c2 cardiocytes against the lipopolysaccharide (LPS)-induced inflammation.

[Lignans from flower buds of Magnolia biondii].

The present study aims to investigate the lignans from the flower buds of Magnolia biondii. The isolation and purification of the compounds were performed by column chromatographies on Diaion HP-20, silica gel, and Sephadex LH-20, combined with semi-preparative HPLC. Their structures were elucidated on the basis of spectral data and physiochemical properties.