Potential Mechanisms of Covid-19 Related Nervous System Damage and Effects on Female Fertility.

Signs and symptoms that persist or worsen beyond the "acute COVID-19" stage are referred to as long-COVID. These patients are more likely to suffer from multiple organ failure, readmission, and mortality. According to a recent theory, long-lasting COVID-19 symptoms may be caused by abnormal autonomic nervous system (ANS) activity, such as hypovolemia, brain stem involvement, and autoimmune reactions.

Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression.

Background: Corosolic acid is a pentacyclic triterpene acid with hypoglycemic, anti-inflammatory, and anti-cancer effects. However, its potential targets in hepatocellular carcinoma (HCC) are unknown, hindering clinical utilization.

Methods: Differentially expressed proteins of the Bel-7404 cell line were identified with tandem mass tag analysis and differentially expressed genes (DEGs) of an HCC TCGA dataset using bioinformatics.

Protective effect of liraglutide on the myocardium of type 2 diabetic rats by inhibiting polyadenosine diphosphate-ribose polymerase-1.

Background: In recent years, studies have found that the occurrence and development of diabetic cardiomyopathy (DCM) is closely related to an increase in polyadenosine diphosphate-ribose polymerase-1 (PARP-1) activity. PARP-1 activation could be involved in the pathophysiological process of DCM by promoting oxidative stress, the inflammatory response, apoptosis and myocardial fibrosis.

Aim: To investigate the mechanism of liraglutide in improving myocardial injury in type 2 diabetic rats, further clarified the protective effect of liraglutide on the heart, and provided a new option for the treatment of DCM.

Effect of liraglutide on endoplasmic reticulum stress in the renal tissue of type 2 diabetic rats.

Background: Liraglutide is a glucagon-like peptide 1 receptor agonist analog that has been found to have a therapeutic effect in diabetes. In addition to its ability to treat diabetes, liraglutide has beneficial effects on the cardiovascular system and kidney as well as other beneficial effects, but its specific mechanism is not clear. In this study, a rat model of type 2 diabetes was established by administration of a high-sugar, high-fat diet combined with low-dose streptozotocin (STZ) to observe the effect of liraglutide on the kidneys of type 2 diabetes rats and the possible underlying mechanisms.

Identification of apoptosis-related microRNAs and their target genes in myocardial infarction post-transplantation with skeletal myoblasts.

Background: Skeletal myoblasts (SkMs) has provided a promising treatment for myocardial infarction (MI). Functioning as posttranscriptional regulators, microRNAs (miRNAs) play important roles in cardiac repairment and stem cell regulation. However, the correlation between miRNAs and their targeted genes in SkM cell therapy for MI was not fully understood.

Novel mechanism of inhibition of dendritic cells maturation by mesenchymal stem cells via interleukin-10 and the JAK1/STAT3 signaling pathway.

Mesenchymal stem cells (MSCs) can suppress dendritic cells (DCs) maturation and function, mediated by soluble factors, such as indoleamine 2,3-dioxygenase (IDO), prostaglandin E(2) (PGE(2)), and nitric oxide (NO). Interleukin-10 (IL-10) is a common immunosuppressive cytokine, and the downstream signaling of the JAK-STAT pathway has been shown to be involved with DCs differentiation and maturation in the context of cancer. Whether IL-10 and/or the JAK-STAT pathway play a role in the inhibitory effect of MSCs on DCs maturation remains controversial.

MiR-499 induces cardiac differentiation of rat mesenchymal stem cells through wnt/β-catenin signaling pathway.

Objective: To test the hypothesis that over-expressing miR-499 in rat bone marrow-derived mesenchymal stem cells (BM-MSCs) induces them to differentiate into cardiomyocyte-like cells through the wnt/β-catenin signaling pathway.

Methods: Rat BM-MSCs were infected with lentiviral vectors bearing miR-499. The expression of cardiac-specific markers, NKx2.

[Enhanced hydrolysis of excess sludge by external enzymes].

The effects of external enzymes to enhance excess sludge hydrolysis were investigated. Protease and alpha-amylase were added singly and in combination, and it was found that external enzymes can enhance sludge hydrolysis. When treated with single enzyme, alpha-amylase had higher efficiency than protease, SCOD/TCOD rose from 16.

Enhanced efficiency of biological excess sludge hydrolysis under anaerobic digestion by additional enzymes.

In this investigation, the effects of commercial enzyme preparation containing alpha amylase and neutral protease on hydrolysis of excess sludge and the kinetic analysis of hydrolysis process were evaluated. The results indicated that amylase treatment displayed higher hydrolysis efficiency than that of protease. VSS reduction greatly increased to 39.

[Enrichment and dynamic analysis of deammonification granules].

Deammonification process was started-up in a sequencing batch reactor (SBR) seeded with anaerobic granular sludge. A kinetic model describing deammonification process was proposed. Due to the presence of concentration gradient of dissolved oxygen (DO) in granular sludge, model correction factors of DO were introduced.

[Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis].

Objective: To investigate the relationship between interleukin-6 (IL-6) gene -572C/G polymorphism and the risk of chronic periodontitis disease.

Methods: IL-6-572C/G genotype polymorphism was examined in 93 patients with chronic periodontitis and 96 control subjects by PCR restriction fragment length polymorphism (PCR-RFLP) method.

Results: IL-6-572GG genotype and G allele were more frequent in chronic periodontitis patients than that in control subjects (P<0.

[Bio-hydrogen production from different pretreated sludge by Pseudomonas sp. GL1 and changes in the liquid phases].

Batch tests of anaerobic fermentative hydrogen production by Pseudomonas sp. GL1 were investigated using sterilization, microwave and ultrasonication pretreated sludge as substrate. The profiles of soluble COD, protein, carbohydrate and pH value during the fermentation process were monitored.

Total concentrations and speciation of heavy metals in municipal sludge from Changsha, Zhuzhou and Xiangtan in middle-south region of China.

The presence of heavy metals in municipal sludge restricts its use for agricultural purposes. In this paper, the bioavailability and eco-toxicity of heavy metals in municipal sludge was evaluated, taking into consideration both the speciation of metals and the local environmental characteristics. The dewatered municipal sludge samples were collected from five sewage plants in Changsha, Zhuzhou and Xiangtan respectively, which are representative cities with characteristics of the middle-south region of China.

Impacts of sterilization, microwave and ultrasonication pretreatment on hydrogen producing using waste sludge.

Hydrogen production by sterilization, microwave and ultrasonication pretreated waste sludge was investigated in this study. A new strain of Pseudomonas sp. GZ1 (EF551040) was inoculated in pretreated waste sludge to produce hydrogen.

[Simultaneous nitrogen and phosphorus removal in the reactor of inner loop SBR without anaerobic phase].

The performance of simultaneous nitrogen and phosphorus removal with an inner loop sequencing batch reactor were investigated by simulated municipal wastewater. The experimental results showed that COD, NH4(+) -N, and TP can be removed efficiently after four hours aeration, during which dissolved oxygen concentration was at 6 mg/L at the beginning of aerobic phase and pH was in the rang of 7 - 8. The COD and NH4+ -N as well as TP concentration in the effluent were about at 4 - 48 mg x L(1), 0 - 2.

Adsorption of Cd(II) and Cu(II) from aqueous solution by carbonate hydroxylapatite derived from eggshell waste.

Carbonate hydroxylapatite (CHAP) synthesized by using eggshell waste as raw material has been investigated as metal adsorption for Cd(II) and Cu(II) from aqueous solutions. The effect of various parameters on adsorption process such as contact time, solution pH, amount of CHAP and initial concentration of metal ions was studied at room temperature to optimize the conditions for maximum adsorption. The results showed that the removal efficiency of Cd(II) and Cu(II) by CHAP could reach 94 and 93.

A two-stage anaerobic system for biodegrading wastewater containing terephthalic acid and high strength easily degradable pollutants.

The high strength easily biodegradable pollutants (represented by CODE) are strong inhibitors of terephthalic acid (TA) anaerobic biodegradation. At the same time, TA can inhibit easily biodegradable pollutants removal under anaerobic conditions to a limited extent. This mutual inhibition could happen and cause a low removal efficiency of both TA and CODE, when the effluent from TA workshops containing TA and easily biodegradable pollutants are treated by a single anaerobic reactor system.