Radiologic Analysis of Causes of Early Recurrence After Percutaneous Endoscopic Transforaminal Discectomy.

Study Design: Retrospective study.

Objective: To analyze the causes of and factors influencing early recurrence after TELD performed in the treatment of lumbar disc herniation.

Methods: We included 285 patients with single-segment lumbar disc herniation treated using transforaminal endoscopy lumbar discectomy TELD from January 2017 to December 2019 at the First Affiliated Hospital of the University of South China.

IL-17 in intervertebral disc degeneration: Mechanistic insights and therapeutic implications.

Intervertebral disc degeneration (IDD) serves as an independent risk factor for lower back pain and is closely associated with spinal musculoskeletal disorders, including lumbar disc herniation, radiculopathy, and myelopathy. Interleukin-17 (IL-17), also named IL-17A, is a critical signature cytokine of T-helper 17 cells. Upon binding to the IL-17 receptor A/C heterodimeric complex, IL-17 can trigger multiple signal transduction pathways to stimulate gene transcription and increase messenger RNA stability.

Comprehensive analysis of N6-methyladenosine (mA) modification during the degeneration of lumbar intervertebral disc in mice.

Objective: To study the N6-methyladenosine (mA) modification pattern of nucleus pulposus (NP) tissue during intervertebral disc degeneration (IDD).

Methods: A standing mouse model was generated, and staining and imaging methods were used to evaluate the IDD model. Methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-seq) was used to analyze mA methylation-associated transcripts in the NP, and real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the expression of methylation-related enzymes and conduct bio-informatics analysis.

Molecular simulations of gas transport in hydrogenated nitrile butadiene rubber and ethylene-propylene-diene rubber.

Diffusion and sorption of five gases (H, N, O, CO, CH) in hydrogenated nitrile butadiene rubber (HNBR) and ethylene-propylene-diene rubber (EPDM) have been investigated by molecular dynamics (MD) and grand canonical Monte Carlo (GCMC) simulations. The diffusion coefficients of gas molecules in HNBR and EPDM are well correlated with the effective penetrant diameter except for CO. CO shows a lower diffusion coefficient due to its linear shape.

Pressure overload-induced cardiac hypertrophy response requires janus kinase 2-histone deacetylase 2 signaling.

Pressure overload induces cardiac hypertrophy through activation of Janus kinase 2 (Jak2), however, the underlying mechanisms remain largely unknown. In the current study, we tested whether histone deacetylase 2 (HDAC2) was involved in the process. We found that angiotensin II (Ang-II)-induced re-expression of fetal genes (Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)) in cultured cardiomyocytes was prevented by the Jak2 inhibitor AG-490 and HDAC2 inhibitor Trichostatin-A (TSA), or by Jak2/HDAC2 siRNA knockdown.