Role of autophagy in the periodontal ligament reconstruction during orthodontic tooth movement in rats.

Background/purpose: Autophagy, a lysosome-based degradation pathway that is reportedly activated by mechanical stress and nutrient deprivation, plays an important role in various physiological and pathological events. The present study investigated the level of autophagy and tumor necrosis factor-α(TNF-α) expression in the periodontal ligaments (PDLs) of Sprague-Dawley (SD) rats to analyze the involvement of autophagy and inflammatory cytokines in orthodontic tooth movement (OTM) and maintaining periodontal tissue homeostasis.

Materials And Methods: SD rats (n = 100) were randomly divided into a control group (n = 10) and an experimental group (n = 90).

[Expression of autophagy-related protein Beclin-1 and microtubule-associated protein 2 light chain 3 in periodontal ligament cells in orthodontic tooth pressure areas].

Objective: To investigate the expression of autophagy-related protein Beclin-1 and microtubule-associated protein 2 light chain 3 (LC3Ⅱ) in periodontal ligament cells in orthodontic tooth pressure areas.

Methods: Sixty male SD rats were randomly divided into a blank control group and nine experimental groups. In the experimental groups, 0.