Publications by authors named "Jing-Han Yuan"
Pressure overload-induced pathological cardiac hypertrophy eventually leads to heart failure (HF). Unfortunately, lack of effective targeted therapies for HF remains a challenge in clinical management. Mixed-lineage leukemia 4 (MLL4) is a member of the SET family of histone methyltransferase enzymes, which possesses histone H3 lysine 4 (H3K4)-specific methyltransferase activity.
View Article and Find Full Text PDFCPhaMAS: An online platform for pharmacokinetic data analysis based on optimized parameter fitting algorithm.
Comput Methods Programs Biomed
May 2024
Article Synopsis
- * A new optimized parameter fitting algorithm, using the Nelder-Mead method, was developed and integrated into a user-friendly online application called CPhaMAS, which facilitates pharmacokinetic data analysis through three main modules.
- * Evaluation results showed that CPhaMAS has improved accuracy in parameter estimation, as indicated by lower mean relative errors in various models, compared to existing software like WinNonlin, while also being easy to use without programming knowledge.
Background: A mouse model of myocardial ischemia-reperfusion (I/R) is widely used to study myocardial ischemia-reperfusion injury (I/RI). However, few studies focus on the direct comparison of the extent of pathological events resulting from variant durations of ischemia and reperfusion process.
Methods: A mouse model of I/RI was established by ligation and perfusion of the left anterior descending coronary artery (LAD), and the dynamic changes were recorded by electrocardiogram at different stages of I/R.