Publications by authors named "Jing-Feng Zhu"
Article Synopsis
- - Immune checkpoint inhibitors (ICIs) have revolutionized tumor treatment by offering high specificity and low side effects, particularly targeting the PD-1/PD-L1 axis which plays a crucial role in how tumors evade the immune system
- - Understanding the regulatory factors affecting the PD-1/PD-L1 axis is essential for enhancing the effectiveness of ICIs and improving patient outcomes in cancer therapy
- - Non-coding RNAs (ncRNAs) have been shown to influence PD-L1 expression in the tumor immune microenvironment, thereby affecting the success of ICI therapies and highlighting their potential as targets for more effective cancer treatments
Background: The most common subtype of lung cancer, called lung adenocarcinoma (LUAD), is also the largest cause of cancer death in the world. The aim of this study was to determine the importance of the METTL7A gene in the prognosis of patients with LUAD.
Methods: This particular study used a total of four different LUAD datasets, namely TCGA-LUAD, GSE32863, GSE31210 and GSE13213.
Background: Hematopoietic stem cell transplantation (HSCT) is widely used in the treatment of hematological diseases. However, complications after transplantation, such as acute and chronic graft--host disease (GVHD), still seriously affect the quality of life and even threaten the lives of patients. There is evidence that glomerular diseases can manifest as GVHD.
View Article and Find Full Text PDFMany factors are involved in the development of cancer pain, which is a serious complication of cancer and affects the quality of life of patients, Normally, drugs are used to relieve pain in clinic, but the effect is not satisfactory to patients. Therefore, it is necessary to explore the molecular basis of the pathogenesis of cancer pain and carry out targeted therapy. Fortunately, the important role of P2X purine receptors dependent on ATP ion channels in the development of cancer pain has been recognized.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to uncover the miRNAs and genes linked to radioresistance in nasopharyngeal carcinoma (NPC) and explore the mechanisms behind this resistance.
- Using microarrays and qRT-PCR, researchers identified 15 miRNAs and 372 mRNAs that differed between radioresistant and sensitive NPC cells, and constructed a regulatory network of 375 miRNA-target gene pairs.
- A key finding was that IL-8 is a direct target of miRNA-23a; when miRNA-23a is downregulated, IL-8 levels increase, contributing to radioresistance in NPC cells.