Publications by authors named "Jing-Feng Wang"

Background: Intraindividual variability in lipid profiles is recognized as a potential predictor of cardiovascular events. However, the influence of early adulthood lipid profile variability along with mean lipid levels on future coronary artery calcium (CAC) incidence remains unclear.

Methods: A total of 2395 participants (41.

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Metabolic responses to cellular stress are pivotal in cell ferroptosis, with mitophagy serving as a crucial mechanism in both metabolic processes and ferroptosis. This study aims to elucidate the effects of high glucose on cardiomyocytes (CMs) and cardiac fibroblasts (CFs) regarding ferroptosis and to uncover the underlying mechanisms involved. We examined alterations in glycolysis, mitochondrial oxidative phosphorylation (OXPHOS), and mitophagy, which are essential for metabolic adaptations and ferroptosis.

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Objective: The impact of comprehensive risk factor control on heart failure (HF) risk and HF-free survival time in individuals with type 2 diabetes (T2D) was evaluated in this study.

Research Design And Methods: This prospective study included 11,949 individuals diagnosed with T2D, matched with 47,796 non-T2D control study participants from the UK Biobank cohort. The degree of comprehensive risk factor control was assessed on the basis of the major cardiovascular risk factors, including blood pressure, BMI, LDL cholesterol, hemoglobin A1c, renal function, smoking, diet, and physical activity.

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Background: Ideal cardiovascular health (CVH) has been associated with reduced cardiovascular disease risk and mortality, but its association with cardiac arrhythmias was still unsettled. In this prospective cohort study, we investigated the relationship between CVH and subsequent arrhythmias risk, including atrial fibrillation (AF)/flutter, ventricular arrhythmias, and bradyarrhythmias.

Methods: Data from 287,264 participants initially free of arrhythmias in the UK Biobank were included in the analysis.

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Article Synopsis
  • A study was conducted to explore the relationship between remnant cholesterol (RC) levels and the incidence of atrial fibrillation (AF) in a large cohort of participants from the UK Biobank, aiming to clarify previous findings about cholesterol and AF risk.
  • Over 12.8 years, results showed that lower RC levels were linked to a higher chance of developing AF, with significant differences noted when comparing various cholesterol level groupings.
  • The findings suggest that low RC is a risk factor for developing AF, independent of other cardiovascular conditions, highlighting the importance of monitoring RC levels in relation to heart health.
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  • - The study explores the link between cardiovascular health (CVH) metrics and the occurrence of major adverse cardiovascular events (MACE) in people with varying sleep patterns, using data from over 208,000 participants in the UK Biobank. - Findings reveal that individuals with both healthy sleep patterns and ideal CVH levels experienced the lowest risk of MACE over a mean follow-up of 12.73 years, with higher CVH scores consistently associated with reduced MACE risk, regardless of sleep quality. - The research highlights the importance of maintaining good sleep health along with optimal CVH to lower cardiovascular disease risk, suggesting that both factors should be considered in health assessments.
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Background And Aims: The associations between dietary vitamin C (VC), vitamin E (VE) intake and aortic aneurysm and dissection (AAD) remain unclear. This study aimed to prospectively investigate the associations between dietary VC and VE with the incident risk of AAD.

Methods And Results: A total of 139 477 participants of UK Biobank cohort were included in the analysis.

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  • - This study aimed to explore how cardiovascular health, measured by Life's Essential 8 (LE8) scores, is linked to vascular complications in people with type 2 diabetes (T2D).
  • - Researchers followed over 11,000 T2D participants without existing vascular issues for about 12 years, finding that higher LE8 scores (indicating better cardiovascular health) were associated with significantly lower risks of both macrovascular and microvascular complications.
  • - The results highlight the importance of maintaining cardiovascular health through lifestyle changes to reduce the risk of serious vascular complications in individuals with T2D.
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Background: The potential influence of tinnitus on cardiovascular disease (CVD) and all-cause mortality has yet to be explored. We aim to examine the correlations between tinnitus and the risk of cardiovascular events and all-cause mortality.

Methods: We conducted a prospective cohort study utilising data from the UK Biobank.

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Background: Emerging evidence has linked daytime napping with the risk of cardiovascular events. Cardiac arrhythmias are considered an early clinical stage for cardiovascular diseases. However, whether napping frequency is associated with incident arrhythmias remains unknown.

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Remnant cholesterol (RC) has been associated with atherosclerotic cardiovascular disease, but its relationship with hypertension remains unclear. This prospective cohort study aimed to investigate the association between RC and subsequent hypertension risk. Data from the UK Biobank, comprising 295,062 participants initially free of hypertension, were analyzed.

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Article Synopsis
  • * A study involving 251,825 participants showed that higher LE8 scores were significantly associated with a reduced risk of developing CKD over an average follow-up of 12.8 years.
  • * The findings indicate that better cardiovascular health, as measured by LE8, correlates with a lower likelihood of CKD, regardless of a person's genetic risk for the disease.
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  • Atg2 is a critical gene involved in autophagy and aging regulation, and its relationship with exercise in skeletal muscle aging is explored.
  • Research using Drosophila showed that both overexpressing Atg2 and exercise improved physical performance, heart function, and lifespan, while also enhancing levels of key related genes.
  • The findings indicate that exercise can counteract the negative effects of decreasing Atg2, promoting healthier aging by stimulating important metabolic pathways and improving muscle health.
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Speckle tracking echocardiography (STE) derived longitudinal strain (LS) and noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) global and regional myocardial function in symptomatic chronic coronary syndrome (CCS) patients using the two promising methods. Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography.

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Aim: To examine the associations between serum albumin and the incidences of diabetes and diabetic microvascular complications in participants of the UK Biobank cohort.

Methods: There were 398,146 participants without diabetes and 30,952 patients with diabetes from the UK Biobank cohort included in this study. Multivariate-adjusted Cox proportional hazard models were used to analyze the association of albumin with the incidences of diabetes and diabetic microvascular complications.

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Background: Excess aldosterone is implicated in vascular calcification (VC), but the mechanism by which aldosterone-MR (mineralocorticoid receptor) complex promotes VC is unclear. Emerging evidence indicates that long-noncoding RNA H19 (H19) plays a critical role in VC. We examined whether aldosterone-induced osteogenic differentiation of vascular smooth muscle cells (VSMCs) through H19 epigenetic modification of Runx2 (runt-related transcription factor-2) in a MR-dependent manner.

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Background: Reduced lung function has been linked to cardiovascular disease, but population-based evidence on the relationship between lung function decline and coronary artery calcium (CAC) progression is rare.

Methods: A total of 2694 participants (44.7% men) with a mean ± standard deviation age of 40.

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Background & Aims: Individuals with high blood pressure (BP) have varying risks of cardiovascular events due to other coexisting factors. We aimed to identify the predictors of long-term absence of coronary artery calcium (CAC) in individuals with high BP, which is an indicator of healthy arterial aging and can guide preventive strategies.

Methods: We analyzed data from participants with high BP (≥120/80 mm Hg) in the Multi-Ethnic Study of Atherosclerosis who had baseline CAC = 0 and underwent a second CAC scanning after 10 years.

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Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodeling, culminating in aortic stenosis, heart failure, and ultimately premature death. Ferroptosis has been hypothesized to contribute to the pathogenesis of CAVD. We aimed to study the association between ferroptosis genes and CAVD and reveal the potential roles of ferroptosis in CAVD.

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Abdominal aortic aneurysm (AAA) is a dangerous vascular disease without any effective drug therapies so far. Emerging evidence suggests the phenotypic differences in perivascular adipose tissue (PVAT) between regions of the aorta are implicated in the development of atherosclerosis evidenced by the abdominal aorta more vulnerable to atherosclerosis than the thoracic aorta in large animals and humans. The prevalence of thoracic aortic aneurysms (TAA) is much less than that of abdominal aortic aneurysms (AAA).

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Purpose: Colchicine, a multipotent anti-inflammatory drug, has been reported to alleviate cardiac remodeling and improve cardiac function after acute myocardial infarction (AMI). However, the underlying mechanism remains incompletely understood. Because neutrophils extracellular traps (NETs) enhance inflammation and participate in myocardial ischemia injury, and colchicine can inhibit NETosis, we thus aimed to determine whether colchicine exerts cardioprotective effects on AMI via suppressing NETs.

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Background: Remnant cholesterol (RC) contributes to residual risk of atherosclerotic cardiovascular disease, but population-based evidence on the prospective relationship between RC and coronary artery calcium (CAC) progression is rare.

Methods: We pooled data obtained from 6544 atherosclerotic cardiovascular disease-free individuals from the CARDIA study (Coronary Artery Risk Development in Young Adults; n=2635) and MESA (Multi-Ethnic Study of Atherosclerosis; n=3909), with a mean±SD age of 47.2±19.

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