Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota.

The relationship between poor in vivo bioavailability and effective pharmacological activity are not yet fully clarified for many flavonoids. The analysis of flavonoids-induced alterations in the gut microbiota represents a promising approach to provide useful clues to elucidate the mechanism of action. Here, we investigate the effect of myricetin supplementation on high-fat-diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in rats and explore the associations with the gut microbiota through high-throughput analyses.

Novel ADAM-17 inhibitor ZLDI-8 inhibits the metastasis of hepatocellular carcinoma by reversing epithelial-mesenchymal transition in vitro and in vivo.

Aims: Epithelial-mesenchymal transition (EMT) is one of the important regulators of metastasis in advanced hepatocellular carcinoma (HCC). Blocking the Notch signaling pathway and then reversing the EMT process is a hot spot in clinical tumor research. Here, we aimed to investigate the effect and underlying mechanisms of ADAM-17 (a key cleavage enzyme of Notch pathway) inhibitor ZLDI-8 we found before on the metastasis of hepatocellular carcinoma in vitro and in vivo.

Advanced treatment of landfill leachate by a new combination process in a full-scale plant.

Advanced treatment of mature landfill leachate from a municipal landfill located in southern China (Jiangmen) was carried out in a full-scale plant using a new process. The combined process has a sequencing batch reactor (SBR) serving as the primary treatment, with polyferric sulfate (PFS) coagulation coupled with a Fenton system as secondary treatment, and a pair of upflow biological aerated filters (UBAFs) in parallel as tertiary treatment. The overall removal efficiency of chemical oxygen demand (COD) in this process was 97.