Biomed Pharmacother
September 2023
Paeonol (PAE) is a natural phenolic monomer isolated from the root bark of Paeonia suffruticosa that has been widely used in the clinical treatment of some inflammatory-related diseases and cardiovascular diseases. Much preclinical evidence has demonstrated that PAE not only exhibits a broad spectrum of anticancer effects by inhibiting cell proliferation, invasion and migration and inducing cell apoptosis and cycle arrest through multiple molecular pathways, but also shows excellent performance in improving cancer drug sensitivity, reversing chemoresistance and reducing the toxic side effects of anticancer drugs. However, studies indicate that PAE has the characteristics of poor stability, low bioavailability and short half-life, which makes the effective dose of PAE in many cancers usually high and greatly limits its clinical translation.
View Article and Find Full Text PDFFluorescein diacetate (FDA) assay has been widely applied in coastal research to quantify microbial activity in sediments. However, the present FDA assay procedures embodied in sediment studies potentially include operational errors since the protocol was established for studies of terrestrial soil. In the present study, we optimised the procedure of FDA assay using sandy and cohesive sediments to improve experiential sensitivity and reproducibility.
View Article and Find Full Text PDFAs land-ocean interaction zones, mangrove systems receive substantial polycyclic aromatic hydrocarbons (PAHs) from sewage and combustion of fossil fuel. In this study, we investigated the relationship between dissolved inorganic nitrogen (DIN) availability and degradation rate of phenanthrene, a typical PAH compound, in mangrove plant-sediment systems, using Avicennia marina as a model plant. After 50 day incubation, phenanthrene removal ratios in sediments ranged from 53.
View Article and Find Full Text PDFObjective: To observe the preventive and control effect of matrine on transforming growth factor (TGF-β1) and hepatocyte growth factor (HGF) of liver fibrosis tissue in rats.
Methods: A total of 48 SD rats were randomly divided into A, B, C, D groups with 12 in each, group A as the normal control group and groups B, C, D as liver fibrosis models using composite modulus method with carbon tetrachloride (CCL4). Group B was the model group, group C adopted γ-interferon lavage therapy in the second day of modeling, and group D adopted matrine lavage treatment, at 4 and 8 weeks after treatment.
The distribution, mobility and potential risks of Cu, Zn, and Pb in four typical plant-sediment co-systems of the Quanzhou Bay estuary wetland in southeast China were investigated using a sequential extraction procedure. The results show that the sediments were moderately or heavily contaminated with Zn and Pb in all four plant communities, and the plant-sediment systems could act as a sink for the heavy metals. In all investigated sediments, only a small proportion of measured heavy metals were distributed in exchangeable fraction and carbonate fraction, while the reducible fraction contained the highest amount of Zn and Pb of the total readily bioavailable fractions, and the oxidizable fraction exhibited a higher retention capacity for Zn and Cu, but lower for Pb.
View Article and Find Full Text PDFScand J Clin Lab Invest
February 2010
Background And Objectives: The Kidd system antibodies, if undetected, can cause immediate or delayed hemolytic transfusion reactions as well as hemolytic disease of the newborn. There have been anecdotal reports about the inefficiency of the manual Polybrene test in detecting these antibodies. Here, we sought to determine the sensitivity of the manual Polybrene test in detecting anti-Jk(a) and anti-Jk(b) antibodies and Jk(a) and Jk(b) antigens.
View Article and Find Full Text PDFZhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
June 2006
Background: To evaluate homemade and imported HbsAg ELISA kits on screening blood donors.
Methods: Samples for evaluation included 120 HbsAg serum plates for the golden criteria and 400 sets of serum from blood donors in Dongguan. The samples underwent blind screening with homemade and imported ELISA kits respectively.