Publications by authors named "Jing-Chen Ma"
Background: Diarrhea remains the leading cause of childhood illness in China. Better understanding of burden and etiology of diarrheal diseases is important for development of effective prevention measures.
Methods: Population-based diarrhea surveillance was conducted in Sanjiang (southern China) year-round and Zhengding (northern China) in autumn/winter.
Article Synopsis
- Rotaviruses are the main cause of severe diarrhea in kids, and certain genetic factors in humans, known as histo-blood group antigens (HBGAs), may influence how these viruses attach and cause infections.
- A study conducted in rural Hebei province, China, analyzed saliva and serum from children to understand the relationship between HBGA secretor status and RV infection risk.
- The findings revealed that a higher percentage of children with RV infections were HBGA secretors compared to non-infected controls, suggesting potential genetic susceptibility and highlighting the need for a universal rotavirus vaccination program in China.
Objective: To assess the immune effect of different types of hepatitis B vaccine (HepB) booster doses 2-32 years after primary immunization, explore the influencing factors, and offer guidance regarding the necessity and timing of boosters.
Methods: In total, 1163 participants who were born from 1986 to 2015, received the HepB full-course primary vaccination, were hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) negative, and had hepatitis B surface antibody (anti-HBs) <10 mIU/mL were enrolled. Individuals were randomly divided into two groups and received a booster dose of HepB.
Article Synopsis
- Researchers studied how common stomach viruses are in young kids in rural China between 2011 and 2013.
- They found that rotavirus was the biggest cause of diarrhea in children, followed by norovirus, especially in kids aged 6 to 18 months.
- The study suggests that vaccines for rotavirus and norovirus are very important for preventing diarrhea in children in China.
: To assess the long-term protection conferred by plasma-derived hepatitis B vaccine at 20-31y after primary immunization during infancy in Chinese rural community.: Participants born between 1986 and 1996, who received a full course of primary vaccination with plasma-derived hepatitis B vaccine and had no experience with booster vaccination were enrolled. An epidemiological investigation was performed, and blood samples were collected to detect hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core antibody (anti-HBc).
View Article and Find Full Text PDFBackground: To assess the immune persistence conferred by a Chinese hamster ovary (CHO)-derived hepatitis B vaccine (HepB) 17 to 20 years after primary immunization during early life.
Methods: Participants born between 1997 and 1999 who received a full course of primary vaccination with HepB (CHO) and who had no experience with booster vaccination were enrolled. Blood samples were required from each participant for measurement of hepatitis B surface antibody (anti-HBs), surface antigen and core antibody levels.
Article Synopsis
- - The study focuses on using a noninvasive imaging technique, specifically radiomics, to identify EGFR mutations in lung adenocarcinoma patients, which is crucial for treatment but can be difficult to test through traditional methods.
- - A total of 503 patients were analyzed, where a random forest model achieved an area under the curve (AUC) of 0.802 for predicting EGFR mutations, which improved to 0.828 by incorporating clinical factors like sex and smoking history.
- - While promising, the study concludes that further enhancements in accuracy, sensitivity, and specificity are needed for this image-based method to be implemented in clinical settings for diagnosis.
Background: In recent years, hepatitis A virus (HAV) infection has declined considerably in China, associated with wide deployment of HAV vaccines and improvement in socio-economic indicators. Towards the elimination of HA in the country, we assessed the duration and characteristics of immunity conferred by the widely used, locally manufactured HAV vaccine.
Methods: This is a longitudinal cohort study that followed recipients of a live attenuated HAV vaccine 17 years after the initial administration.
Article Synopsis
- A population-based study was conducted in rural Hebei, China, from October 2011 to March 2012, to understand the distribution and evolution of norovirus among children under 5 years old, focusing on diarrhea cases.
- Using RT-PCR, researchers identified and sequenced norovirus strains, discovering five genotypes with GII.3 and GII.4 as the most common, comprising 45.22% and 40.87% of cases, respectively.
- The study revealed that GII.3 noroviruses evolved at a faster rate (6.29×10 nucleotide substitutions/site/year) than GII.4 noroviruses (3.67×10 s/s/y), contradicting the current
A universal rotavirus (RV) immunization program is a potentially cost-effective measure for preventing RV infection in China. However, the efficacy of the only licensed RV vaccine (Lanzhou lamb rotavirus vaccine, LLR), which is made by a domestic manufacturer, has not been proven by a properly designed clinical trial. In October 2011 to March 2012, to measure the potential protection provided by LLR, a case-control study nested in a population-based active diarrhea surveillance study of children <5 years of age was conducted in rural Zhengding county.
View Article and Find Full Text PDFObjective: To study the epidemiological patterns of hepatitis A, and immunity of entire population in Shijiazhuang prefecture, Hebei province, a former hyper-endemic area in north China.
Methods: Cross-sectional, seroprevalence surveys with two-stage cluster sampling were conducted among population older than 2-year between 1992 and 2011. During the 2011 serological survey, blood samples from infants <18 months without hepatitis A immunization history were also collected to determine maternal anti-HAV antibody.
Objective: To evaluate the long-term efficacy of Chinese hamster ovary (CHO) cell derived hepatitis B vaccine in country community in China.
Methods: A cross-sectional investigation was carried out. Children who were born between 1997 and 1999 and vaccinated with the three doses of CHO-derived hepatitis B vaccine were selected as study objects.
Influenza and bacterial pathogen coinfections in the 20th century.
Interdiscip Perspect Infect Dis
July 2011
To help understand the potential impact of bacterial coinfection during pandemic influenza periods, we undertook a far-reaching review of the existing literature to gain insights into the interaction of influenza and bacterial pathogens. Reports published between 1950 and 2006 were identified from scientific citation databases using standardized search terms. Study outcomes related to coinfection were subjected to a pooled analysis.
View Article and Find Full Text PDFObjective: To evaluate the effectiveness of a Chinese hamster ovary cell derived hepatitis B vaccine in a country community in Hebei Province, PR China.
Method: A cross-sectional investigation was carried out in 4 of 7 randomly selected country communities in Zhengding County in 2005. All of the children who were born between 1997 and 1999 were selected as study objects.
Article Synopsis
- Shigellosis is a significant public health issue in China, particularly affecting children under 5, and traditional culture methods may underestimate its prevalence.
- Real-time PCR was used in this study to detect Shigella infections alongside routine culture, revealing a higher true burden of disease.
- The study found that 58% of culture-negative specimens were positive for Shigella DNA, indicating that conventional methods may overlook many cases, highlighting the need for improved detection techniques.
[The immunological effects of three doses of a live attenuated hepatitis A vaccine (H2 strain) in 8 years].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
June 2009
Objective: To observe the immunological effects of three doses of H2 strain live attenuated hepatitis A vaccine 8 years after the administration and to compare with that of one dose of the vaccine.
Methods: In a country area, 110 children of 1 to 7 years old susceptible to HAV were screened and administered with one dose of the vaccine, as group B; Group A were 42 children from one of the villages and administered with 3 doses of the vaccine according to 0, 2, 6 month schedule. Blood samples were taken for the children 1, 2, 6, 7, 8, 12, 24, 36 and 96 months after the administrations respectively and detected for anti-HAV antibody.
[Evaluation of 5 kinds of China-made enzyme immuoassay kits for antibody to hepatitis B virus core antigen detection].
Zhongguo Yi Miao He Mian Yi
October 2009
Objective: To Screen an EIA kit that fits best for using in serological detection of anti-HBc in the national investigation of hepatitis B virus infection.
Methods: Top 5 kinds of kits on the best seller list of China-made anti-HBc EIA kit were selected and each detect the anti-HBc panel (95 positive and 57 negative) 5 times. The co/s ratio of each test was recorded and transformed by Ig(co/s+1).
[Evaluation of 5 kinds of China-made enzyme immunoassay kits for antibody to hepatitis B virus e antigen detection].
Zhongguo Yi Miao He Mian Yi
October 2009
Objective: The aim of this study is to select a better one from five EIA kits made in China for the serological detection of anti-HBe in a national hepatitis B survey.
Methods: Top 5 kinds of kits on the best seller list of China-made anti-HBe EIA detection were selected and each was detected the anti-HBe panel (66 positive and 88 negative) 5 times. The co/s ratio of each test was recorded and transformed by log(co/s+1).
[Evaluation of 5 kinds of China-made enzyme immunoassay kits for antibody to hepatitis B virus surface antigen detection].
Zhongguo Yi Miao He Mian Yi
October 2009
Objective: To Screen an EIA kit that fits best for using in serological detection of anti-HBs in the national investigation of hepatitis B virus infection.
Methods: Top 5 kinds of kits on the best seller list of China-made anti-HBs EIA detection kits were selected and each was detected the anti-HBs panel(44 positive and 108 negative) 5 times. The s/n ratio of each test was recorded and transformed by log(s/n+1).
[Evaluations of 5 kinds of China-made enzyme immunoassay kits for hepatitis B virus surface antigen detection].
Zhongguo Yi Miao He Mian Yi
October 2009
Unlabelled: OBJECTIVE To Screen best EIA kit that fits best for using in serological detection of HBsAg in the national investigation of hepatitis B virus infection.
Methods: Top 5 kinds of kits on the best seller list of China-made HBsAg EIA detection reagents were selected and each was detected the HBsAg panel (63 positive and 90 negative) 5 times. The s/n ratio of each test was recorded and transformed by log (s/n+1).
Objective: To establish HBV marker panels.
Methods: 155 blood plasma specimens were selected and each was detected twice for 5 HBV markers with MEIA kits made by Abbott. Any plasma that had 2 positive or negative results were enrolled in the HBV marker panels and others were excluded.
[The analysis of "alpha" dominant mutation of hepatitis B virus in community-based Zhengding area, Hebei province].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
February 2009
Objective: To determine the "alpha"dominant mutation of hepatitis B virus (HBV) in community-based Zhengding. Analysis the role of the newborn hepatitis B vaccination on the mutation.
Methods: Based on the national surveillance of hepatitis B, 11,478 people's sera were collected and tested by SPRIA with kits.
Article Synopsis
- * During the research period, 125 out of 500 recorded diarrhea cases were due to rotavirus, leading to a significant hospitalization rate and an estimated annual incidence of 61.4 cases per 1000 children.
- * Implementing a universal rotavirus vaccination could prevent a substantial number of diarrhea cases and hospitalizations, resulting in significant healthcare savings and highlighting the economic viability of such a program in the region.
[A nested case control study for risk factors impacting hepatitis B vaccination in Hebei, China].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
June 2008
Objective: Study the risk factors that impact the effectiveness of mass hepatitis B vaccination, and try to amend them in the future.
Method: Based on the national surveillance of hepatitis B, all the 1734 of 1-15 years old children from Hebei Province were enrolled in the present study and they were divided into case and control group according to their sera HBsAg were positive or not.
Results: Mother sera HBsAg positive and the hospital the children were born and earlier year of birth were risk factors.