Power Efficiency Enhancement of Organic Light-Emitting Diodes Due to the Favorable Horizontal Orientation of a Naphthyridine-Based Thermally Activated Delayed Fluorescence Luminophore.

Four emitters based on the naphthyridine acceptor moiety and various donor units exhibiting thermally activated delayed fluorescence (TADF) were designed and synthesized. The emitters exhibited excellent TADF properties with a small Δ and a high photoluminescence quantum yield. A green TADF organic light-emitting diode based on 10-(4-(1,8-naphthyridin-2-yl)phenyl)-10-phenothiazine exhibited a maximum external quantum efficiency of 16.

Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore.

Leprosy is also known as Hansen disease, as in some countries the diagnosis of leprosy carries a negative stigma and patients fear being shunned as outcasts. Presently, leprosy is primarily limited to specific geographical regions in resource-poor countries. As a result, there is increased difficulty for the younger generation of physicians today to correctly identify leprosy due to a lack of exposure and a low-index of suspicion, particularly in developed countries.

A Fatal Case of "Bullous Erysipelas-like" Pseudomonas Vasculitis.

Erysipelas is a generally benign superficial bacterial skin infection, and its bullous form constitutes a rare and more severe variant. We describe the first and fatal case of "bullous erysipelas-like" septic vasculitis due to Pseudomonas bacteremi. A 69-year-old Chinese man presenting with diarrhea and septic shock initially began to rapidly develop sharply defined erythematous plaques with non-hemorrhagic bullae over his lower limbs.

[Preparation of human meniscus acellular matrix].

Objective: To investigate development of a cell extraction process for preparing human meniscus acellular matrix, and morphology and biomechanical properties.

Methods: Human meniscus were subjected to modified eight-step detergent, then, the specimens were assessed by staining with haematoxylin-eosin, toluidine blue, sirius red, saffron O, alcain blue and hoechst-33258, et al. The ultrastructure of the specimens was observed with scanning electron microscope.

Development of rabbit meniscus acellular matrix.

Objective: To prepare a rabbit meniscus acellular matrix scaffold and explore the histomorphological and biomechanical properties of the scaffold.

Methods: Rabbit meniscuses were collected and acellularized using a modified eight-step detergent process with hydrogen peroxide, distilled water, Triton X-100, and sodium deoxycholate. Its color and texture were observed.

[Mechanisms of autologous chondrocytes mass transplantation in the repair of cartilage defects of rabbits' knee].

Objective: To trace the pathological changes of the cultured autologous chondrocytes mass after implanted in cartilage defects and investigate the pathophysiological mechanisms of the antologous chondrocytes mass transplantation in the repair of cartilage defects.

Methods: Twenty-four New Zealand white rabbits of 4 to 6 month-old and weighing more than 3.0 kg (female and male was unrestricted) were randomly divided into experiment group and the control group.

[Blood supply of liver metastasis].

Objective: To probe the blood supply of liver metastasis by celiac arteriography, proper hepatic arteriogaphy, pure portal vein perfusion CT.

Methods: Fifty patients with liver metastasis were examined prospectively by plain CT scan, multiphase enhanced CT scan, celiac arteriography and proper hepatic arteriography, of whom, 23 were examined by pure portal vein perfusion CT during superior mesenteric arterial portography. The imaging manifestations were observed, and the time attenuation curves (TDC)of tumor center, tumor edge, portal vein and normal liver parenchyma were used to calculate liver perfusion with a software of PhotoShop(used in DSA image analysis)and a deconvolution model (CT perfusion software) designed for the dual blood supply.

[The interactions of stromal-epithelial in a model of co-culture in the rabbit cornea].

Objective: The purpose of the study is to produce a reconstructed cornea including epithelia and stroma by tissue engineering. The reconstructed tissue may provide a physiologic model for the investigations of interaction between corneal epithelial cells and keratocytes.

Methods: Epithelial cells and keratocytes were isolated from rabbit corneas and cultured on plastic substrates in vitro.

[Biological characterization of rabbit's articular chondrocytes by confluent culture in vitro].

Objective: To obtain large amount of differentiated chondrocytes in vitro, examine and compare the biological characterization of rabbits' articular chondrocyte cultured in different density in vitvo.

Methods: From November 2001 to June 2004, articulate tissues were obtained from the joints of the adult rabbits. Chondrocytes were isolated from the cartilage tissue with type II collagenase digestion and cultured in DMEM/F-12 supplemented with 20% fetal bovine serum (FBS).

[The preparation, structure evaluation and preliminary application of biomimetic biphasic calcium phosphate scaffold].

Objective: To fabricate biomimetic biphasic calcium phosphate BCP ceramic scaffolds using three-dimensional (3D) gel-lamination technology and evaluated their structure with 3D parameters and related method.

Methods: Series two-dimensional images of femoral head's specimen of dogs were obtained by micro-computed tomography (Micro-CT). According to these images, porous biomimetic biphasic calcium phosphate (BCP) ceramic scaffolds with oriented trabecular structure were fabricated by three-dimensional (3D) gel-lamination technology.

[Comparative study on the main biological characteristics of marrow-derived stromal cells and chondrocytes in vitro culture in rabbits].

Objective: To observe the main biological characteristics and chondrogenesis potency of bone marrow-derived stromal cells (MSCs) after cytokines induction or gene modification in vitro.

Methods: MSCs from an adult New Zealand white rabbit were isolated and cultivated, and then MSCs were divided into the common medium group (Group A, 15% FBS in DMEM), the induced group by cytokines (Group B), the transfected group (Group C) with adenovirus-hepatocyte growth factor transgene (adHGF). The medium of group B consisted of transforming growth factor-beta 1 (TGF-beta 1, 10 ng/ml), basic fibroblast growth factor (bFGF, 25 ng/ml) and dexamethasone (DEX, 10(-7) mol/L) with 15%FBS in DMEM.

[An experimental study of demineralized bone matrix to repair bone defects as a scaffold of tissue engineering].

Objective: To evaluate application of the sponge of demineralized bone matrix (SDBM) in tissue engineering of bone.

Methods: SDBM was prepared from long bone of rabbits. Bone marrow cells were flushed from the bone shaft of femurs of a two-month-old New Zealand white rabbit.

[Experimental study on repair of articular cartilage defect in large area with chondrocytes cultured on fascia].

Objective: To study the biological characteristic and potential of chondrocytes grafting cultured on fascia in repairing large defect of articular cartilage in rabbits.

Methods: Chondrocytes of young rabbits were isolated and sub-cultured on fascia. The large defect of articular cartilage was repaired by grafts of freeze-preserved and fresh chondrocytes cultured on fascia, and free chondrocytes respectively; the biological characteristic and metabolism were evaluated by macroscopic, histological and immunohistochemical observations, autoradiography method and the measurement of nitric oxide content 6, 12, 24 weeks after grafting.