An Efficient and Flexible Bifunctional Dual-Band Electrochromic Device Integrating with Energy Storage.

Dual-band electrochromic devices capable of the spectral-selective modulation of visible (VIS) light and near-infrared (NIR) can notably reduce the energy consumption of buildings and improve the occupants' visual and thermal comfort. However, the low optical modulation and poor durability of these devices severely limit its practical applications. Herein, we demonstrate an efficient and flexible bifunctional dual-band electrochromic device which not only shows excellent spectral-selective electrochromic performance with a high optical modulation and a long cycle life, but also displays a high capacitance and a high energy recycling efficiency of 51.

Performance investigation of MVMD-MSI algorithm in frequency recognition for SSVEP-based brain-computer interface and its application in robotic arm control.

This study focuses on improving the performance of steady-state visual evoked potential (SSVEP) in brain-computer interfaces (BCIs) for robotic control systems. The challenge lies in effectively reducing the impact of artifacts on raw data to enhance the performance both in quality and reliability. The proposed MVMD-MSI algorithm combines the advantages of multivariate variational mode decomposition (MVMD) and multivariate synchronization index (MSI).

Orchestrated desaturation reprogramming from stearoyl-CoA desaturase to fatty acid desaturase 2 in cancer epithelial-mesenchymal transition and metastasis.

Background: Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl-CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have recently been highlighted. However, how tumors initiate and sustain their self-sufficient FA desaturation to maintain phenotypic transition remains elusive.

[Absorption mechanism of iron oxide nanoparticles in Caco-2 cell model].

Objective: To explore the possible mechanism of absorption of iron oxide nanoparticles into the human body through the gastrointestinal tract.

Methods: This article used Caco-2 monolayer cells as a cell model, prepared characterized iron oxide nanoparticles(Fe_2O_3 NPs) as suspensions, and intervened in Caco-2 cells. CCK-8 method, transwell method, and atomic spectrophotometer method were used to explore the effect of Fe_2O_3 NPs on the activity of Caco-2 cells and the absorption and transport of them through the Caco-2 monolayer cell model.

Brillouin assessment of the crystalline lens in patients with high myopia after long-term implantable collamer lens V4c implantation.

Purpose: To evaluate the long-term effects of implantable collamer lens (ICL) V4c on the biomechanical and morphological properties of crystalline lenses in Chinese adults with high myopia using Brillouin microscopy (BM).

Methods: In this case-control study, 102 highly myopic eyes from 102 patients (18-48 years, preoperative spherical equivalent (SE): -6.00--21.

Liver transplantation in a boy with TFAM mutation associated mtDNA depletion syndrome.

Mitochondrial transcription factor A (TFAM) deficiency may cause mtDNA depletion syndrome, which manifests as neonatal liver failure or primary ovarian insufficiency, hearing loss, seizures, and intellectual disability. Treatment focusing on symptomatic management, and the clinical prognosis remains poor. Here, we describe a novel case of TFAM mutation presenting with progressive neonatal cholestasis, hypoglycemia and abnormal amino acid profiling.

Mechanism and Process Optimization in the Electrooxidation of Oxalic Acid Using BDD Electrode under Nitric Acid Environment.

Various electrochemical tests were carried out to elucidate the electrolytic oxidation mechanism of oxalic acid on a boron-doped diamond electrode in a nitric acid environment. These included cyclic voltammetry, AC impedance, constant current electrolysis, and electron paramagnetic resonance spectroscopy. The impact of electrode potential, current density, nitric acid concentration, and electrode plate spacing on the oxidation of oxalic acid was investigated.

Synergistic efficacy of phage Henu10 with antibiotics against with insight into phage resistance and fitness trade-offs.

Introduction: The irrational use of antibiotics has facilitated the emergence of multidrug- resistant ., undermining the effectiveness of the currently available antibiotics. Consequently, there is an urgent need to explore new approaches, with phage therapy emerging as a promising alternative.

Cysteine-induced disulfide cleavage enhances the solubility of alkali-treated pea protein and its elasticity contribution in low-salt hybrid meat gels.

This study investigated the effectiveness of cysteine in improving the functional properties of pea proteins within low-salt myofibrillar protein (MP) gels. Cysteine treatment, at a concentration of 3.3 mM/g protein, cleaved 71-82 % of the disulfide bonds in native and pH-shifted pea protein isolates (PPI and PPI), which increased the solubility and hydrophobicity of PPI.

Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain.

Introduction: We investigated the neural correlates of cognitive decline in visual word perception from the perspective of intrinsic brain networks.

Methods: A total of 19 healthy older adults and 22 young adults were recruited to participate in two functional magnetic resonance imaging (fMRI) sessions (one resting-state session and one for localizer tasks), along with a visual word perceptual processing task. We examined age-related alterations in resting-state functional connectivity (FC) within the word network, as well as between the word network and other networks.

Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT's Aptitude in Pharmacology.

Background: Due to the lack of a comprehensive pharmacology test set, evaluating the potential and value of large language models (LLMs) in pharmacology is complex and challenging.

Aims: This study aims to provide a test set reference for assessing the application potential of both general-purpose and specialized LLMs in pharmacology.

Methods: We constructed a pharmacology test set consisting of three tasks: drug information retrieval, lead compound structure optimization, and research trend summarization and analysis.

mutation-related immune checkpoint molecule absent in melanoma 2 () contributes to immune infiltration in pediatric and adult acute myeloid leukemia: evidence from bioinformatics analysis.

Background: The use of FMS-like tyrosine kinase 3 () as a crucial target for kinase inhibitors is well established, but its association with immune infiltration remains unclear. This study aimed to explore the relationship between mutations and immune checkpoint molecules (ICMs) in patients with acute myeloid leukemia (AML).

Methods: The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases were used to identify the ICMs associated with mutations.

Clinical characteristics and genetic analysis of four pediatric patients with Kleefstra syndrome.

Background: Kleefstra syndrome spectrum (KLEFS) is an autosomal dominant disorder that can lead to intellectual disability and autism spectrum disorders. KLEFS encompasses Kleefstra syndrome-1 (KLEFS1) and Kleefstra syndrome-2 (KLEFS2), with KLEFS1 accounting for more than 75%. However, limited information is available regarding KLEFS2.

Clinical study of two mandibular advancement devices in the treatment of Obstructive Sleep Apnea: a pilot randomized controlled trial.

Objective: A preliminary clinical evaluation of the efficacy, comfort, and adverse reactions of two mandibular advancement devices (MADs) in the treatment of Obstructive Sleep Apnea (OSA).

Methods: Forty patients with mild-to-severe OSA were recruited and randomly divided into two groups. They were treated with Shark-fin or Silensor MAD, respectively.

Effect of adding heparin to parenteral nutrition on catheter intraluminal obstruction based on scanning electron microscopy in preterm neonates: A non-inferiority, randomized controlled trial.

Objectives: This study aimed to assess the need for adding heparin to parenteral nutrition (PN) on reducing catheter intraluminal obstruction based on scanning electron microscopy (SEM) of peripherally inserted central catheter (PICC) in preterm neonates.

Methods: In this randomized controlled blinded non-inferiority trial, neonates with gestational age <32 weeks requiring PICC to receive PN were enrolled and randomly divided into two groups. In the heparin group, 0.

Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Recurrent Small Hepatocellular Carcinoma: A Randomized, Open-Label, Controlled Trial.

Purpose: To assess the efficacy and safety of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in treating recurrent small hepatocellular carcinoma (HCC).

Methods: In this trial, patients with recurrent small HCC (single lesion ≤5 cm) were randomly assigned to receive either SBRT or RFA. The primary end point was local progression-free survival (LPFS), and secondary end points were progression-free survival (PFS), overall survival (OS), local control rate, and safety.

[Ovarian function in patients of childbearing age with systemic lupus erythematosus].

Objective: To explore the ovarian function and its influencing factors in women of childbearing age with systemic lupus erythematosus (SLE).

Methods: A total of 107 female patients diagnosed with SLE at Peking University People' s Hospital from January 2017 to May 2024, aged between 20 and 40 years, were included in the study. At the same time, 40 matched healthy women aged between 20 and 40 years were selected as controls.

Relationship Between Fear of Childbirth and Oral Health-Related Quality of Life in Pregnant Women: The Mediating Effect of Pregnancy Anxiety.

Background: Psychosocial health affects oral health-related quality of life. Pregnancy, as a special time for women, produces significant psychological changes. However, the relationship between mental health during pregnancy and oral health-related quality of life is unclear.

Therapeutic efficacy and safety of botulinum toxin A injection in plantar fasciitis: A systematic review and meta-analysis.

Objective: The purpose of this meta-analysis was to evaluate the therapeutic efficacy and safety of botulinum toxin A (BTA) injections for treatment of plantar fasciitis (PF).

Methods: This review adhered to the PRISMA guidelines, conducting a comprehensive search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases for eligible studies from their inception to December 30 2023. The inclusion criteria were limited to randomized controlled trials (RCTs) comparing BTA injections with control interventions in terms of pain reduction, functional improvement, or the occurrence of adverse events in treating patients with PF were extracted for meta-analysis.

Validation of the clinical assessment scale for autoimmune encephalitis in a severe autoimmune encephalitis cohort.

Objective: The Clinical Assessment Scale for Autoimmune Encephalitis (CASE) is a novel tool tailored specifically for evaluating the severity of autoimmune encephalitis (AE). However, its application in severe AE patients is limited. This study aimed to evaluate the reliability and validity of the CASE and explore its clinical significance in a severe AE cohort.

Severe Epstein-Barr virus encephalitis with peripheral nerve damage: A case report.

Rationale: Epstein-Barr virus (EBV) is a B-lymphotropic double-stranded DNA virus. Most people infected with EBV are asymptomatic infection. Its clinical symptoms are rarely manifested as EBV encephalitis, and peripheral nerve damage is even rarer.

Prediction method of particle size qualification rate of high-pressure roller mill based on end-edge-cloud synergy.

The pass rate of granules is an essential indicator during the high-pressure grinding process, as it accurately reflects the processing quality. Currently, the pass rate of granules is detected primarily based on manual experience judgments or offline inspections. Hence, this article presents a methodology for predicting the pass rate of granularity via an optimized support vector regression approach improved through genetic algorithms.

The therapeutic effects of theta burst stimulation on negative symptoms in chronic schizophrenia using functional near-infrared spectroscopy.

Background: To explore the efficacy of theta burst stimulation (TBS) on the negative symptoms in patients with chronic schizophrenia, and to investigate the alterations of local brain activity using functional near-infrared spectroscopy (fNIRS).

Methods: 100 patients with chronic schizophrenia were enrolled and divided into the real group (50 subjects) and sham group (50 subjects). The real group was given real stimulation of TBS for 4 weeks, and the sham group was sham-stimulated with the same site.