Dual functions of silibinin in attenuating aortic dissection via regulating iron homeostasis and endoplasmic reticulum stress against ferroptosis.

Aortic dissection (AD) poses a significant threat to cardiovascular health globally, yet its underlying mechanisms remain elusive. Smooth muscle cells death and phenotypic switching are critically important pathological processes in AD. Currently, no pharmacological therapies have proven effective in managing AD.

[Research progress in molecular pharmacognosy of Andrographis paniculata].

Molecular pharmacognosy as an emerging interdisciplinary subject based on molecular biology and Chinese materia medica aims to study the synthesis and molecular regulation of secondary metabolites in medicinal plants. Andrographis Herba, the dried aboveground part of Andrographis paniculata, has liver-protecting, bile secretion-promoting, heat-clearing, toxin-removing, antimicrobial, and anti-inflammatory effects. The quality instability caused by plant varieties, environment, and technology in the production of A.

Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction.

Novel CHCHD2 mutations causing C-terminal truncation and interrupted CHCHD2 protein stability in Parkinson's disease (PD) patients were previously found. However, there is limited understanding of the underlying mechanism and impact of subsequent CHCHD2 loss-of-function on PD pathogenesis. The current study further identified the crucial motif (aa125-133) responsible for diminished CHCHD2 expression and the molecular interplay within the C1QBP/CHCHD2/CHCHD10 complex to regulate mitochondrial functions.

Novel PLCZ1 mutation caused polyspermy during in vitro fertilization.

Failure of oocyte activation, including polyspermy and defects in pronuclear (PN) formation, triggers early embryonic developmental arrest. Many studies have shown that phospholipase C zeta 1 ( PLCZ1 ) mutations cause failure of PN formation following intracytoplasmic sperm injection (ICSI); however, whether PLCZ1 mutation is associated with polyspermy during in vitro fertilization (IVF) remains unknown. Whole-exome sequencing (WES) was performed to identify candidate mutations in couples with primary infertility.

[Genome-wide identification and expression analysis of TCP gene family of Andrographis paniculata under abiotic stress].

Andrographis paniculata is an important medicinal plant in the Lingnan region of China, which has the functions of clearing heat, removing toxins, and resisting bacteria and inflammation. The TCP gene family is a class of transcription factors that regulate plant growth, development, and stress response. In order to analysis the role of the TCP gene family under abiotic stress in A.

Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies.

This study evaluated the reno-protective effects of quercetin in animal models of acute kidney injury (AKI). We conducted a systematic search of literature published before April 2023 in PubMed, Web of Science, and EMBASE databases. Methodological quality was assessed by SYRCLE's RoB tool.

Effectiveness of acupuncture treatment for stroke and stroke complications: a protocol for meta-analysis and systematic review based on randomized, single-blind, controlled trials.

Introduction: The treatment and rehabilitation of stroke and its complications have become major global health issues. Acupuncture is widely used as a complementary and alternative treatment for stroke. Many clinical studies have evaluated the efficacy and safety of acupuncture, but the research results need to be more consistent.

Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression.

Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby reducing the success rate of assisted reproductive technology (ART). Potential preventative strategies preventing oocytes from aging and the associated underlying mechanisms warrant investigation. In this study, we identified that cordycepin, a natural nucleoside analogue, promoted the quality of oocytes aging in vitro, as indicated by reduced oocyte fragmentation, improved spindle/chromosomes morphology and mitochondrial function, as well as increased embryonic developmental competence.

Spatially and temporally understanding dynamic solid-electrolyte interfaces in carbon dioxide electroreduction.

The ubiquity of solid-liquid interfaces in nature and the significant role of their atomic-scale structure in determining interfacial properties have led to intensive research. Particularly in electrocatalysis, however, a molecular-level picture that clearly describes the dynamic interfacial structures and organizations with their correlation to preferred reaction pathways in electrochemical reactions remains poorly understood. In this review, CO electroreduction reaction (CORR) is spatially and temporally understood as a result of intricate interactions at the interface, in which the interfacial features are highly relevant.

Growth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice.

Background: The global delay in women's reproductive age has raised concerns about age-related infertility. The decline in oocyte quality is a limiting factor of female fertility, yet there are currently no strategies to preserve oocyte quality in aged women. Here, we investigated the effects of growth hormone (GH) supplementation on aneuploidy of aged oocytes.

Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial.

Importance: Intravenous thrombolysis is increasingly used in patients with minor stroke, but its benefit in patients with minor nondisabling stroke is unknown.

Objective: To investigate whether dual antiplatelet therapy (DAPT) is noninferior to intravenous thrombolysis among patients with minor nondisabling acute ischemic stroke.

Design, Setting, And Participants: This multicenter, open-label, blinded end point, noninferiority randomized clinical trial included 760 patients with acute minor nondisabling stroke (National Institutes of Health Stroke Scale [NIHSS] score ≤5, with ≤1 point on the NIHSS in several key single-item scores; scale range, 0-42).

Exposed Zinc Sites on Hybrid ZnIn S @CdS Nanocages for Efficient Regioselective Photocatalytic Epoxide Alcoholysis.

Photocatalytic epoxide alcoholysis through C-O bond cleavage and formation has emerged as an alternative to synthesizing anti-tumoral pharmaceuticals and fine chemicals. However, the lack of crucial evidence to interpret the interaction between reactants and photocatalyst surface makes it challenging for photocatalytic epoxide alcoholysis with both high activity and regioselectivity. In this work, we report the hierarchical ZnIn S @CdS photocatalyst for epoxide alcoholysis with high regioselectivity nearly 100 %.

Homo-valent diruthenium(II,II) carbonates Na[Ru(CO)]·10HO: synthesis, structure, properties, and calculation.

Homo-valent diruthenium(II,II) carbonates have been underexplored hitherto. This paper reports the synthesis and crystal structure of a diruthenium(II,II) compound, NaRu(CO)·10HO (1). It has a two-dimensional structure in which the paddle-wheel diruthenium units of Ru(CO) are cross-linked through the carbonate groups.

[Research hotspots and trends of urban stormwater management in China based on resilience theory.].

Under the context of frequent flood disasters in China, stormwater management practices such as sponge cities can play a role in flood mitigation and improve the 'resilience' of cities to flood. Resilient city is a concept related with adaptation to disasters, which is increasingly applied to stormwater and flood risk management in some countries. Based on the theory of resilience, we used the scientific metrological analysis tool CiteSpace to review the actualities of Chinese research on rainfall flood, analyzed the hot spots and related technologies of stormwater management from three aspects including ecology, engineering and society of stormwater resilience.

Incidence and risk factor analysis for swelling after apical microsurgery.

Background: Swelling after apical microsurgery is a postoperative reaction and may reduce quality of life during healing.

Aim: To evaluate periapical swelling after apical microsurgery and determine potential risk factors.

Methods: Ninety-eight apical microsurgery patients were selected for this study.

[Analysis of the underlying mechanisms of green tide with a perspective of algae ecophysiology].

Green tide in the sea is an abnormal ecological phenomenon caused by the explosive proliferation or high aggregation of some green macroalgae under particular environmental conditions. Since 2007, green tides have occurred in the Yellow Sea for 15 consecutive years, resulting in extremely serious damage to coastal ecological environment, social development, and economic construction. Therefore, it is urgent to solve the green tide problem, which is driven by external and internal factors.

[Identification and expression analysis of R2R3-MYB gene family in Andrographis paniculata].

The plant growth, development, and secondary metabolism are regulated by R2 R3-MYB transcription factors. This study identified the R2 R3-MYB genes in the genome of Andrographis paniculata and analyzed the chromosomal localization, gene structure, and conserved domains, phylogenetic relationship, and promoter cis-acting elements of these R2 R3-MYB genes. Moreover, the gene expression profiles of R2 R3-MYB genes under abiotic stress and hormone treatments were generated by RNA-seq and validated by qRT-PCR.

Heck Reaction Boosted Heterocycle Ring-Closing and Ring-Opening Rearrangement: A Strategy for the Synthesis of Indolyl-Type Ligands.

A novel method for P-involved heterocycle ring-closing-ring-opening rearrangement (HRR) via the Heck reaction is disclosed. The approach enables direct installation of a phosphorus-containing aryl group onto the C2 position of indole. This new rearrangement directly transforms easily prepared indole derivatives into indolyl-derived phosphonates and phosphinic acids with high yields, and many of the products are difficult to obtain by using established methods.

Prolonged interval time between blastocyst biopsy and vitrification compromised the outcomes in preimplantation genetic testing.

This study aimed to evaluate to what extent the different interval times between trophectoderm (TE) biopsy and vitrification influence the clinical outcomes in preimplantation genetic testing (PGT) cycles. Patients who underwent frozen embryo transfer (FET) after PGT between 2015 and 2019 were recruited. In total, 297 cycles with single day 5 euploid blastocyst transfer were included.

Application of Conchal Cartilage Grafts in Nasal Tip Plasty: Comparison and Experience of 3 Methods.

Introduction: The autologous conchal cartilage of good elasticity is easy to harvest, thus is often used in nasal tip plasty of East Asians. However, the operation techniques vary a lot among different surgeons. This article aims to introduce 3 techniques commonly used in clinical practice.

Cooperative Syngas Production and C-N Bond Formation in One Photoredox Cycle.

Solar-driven syngas production by CO reduction provides a sustainable strategy to produce renewable feedstocks. However, this promising reaction often suffers from tough CO activation, sluggish oxidative half-reaction kinetics and undesired by-products. Herein, we report a function-oriented strategy of deliberately constructing black phosphorus quantum dots-ZnIn S (BP/ZIS) heterostructures for solar-driven CO reduction to syngas, paired with selectively oxidative C-N bond formation, in one redox cycle.

Unexpected Boosted Solar Water Oxidation by Nonconjugated Polymer-Mediated Tandem Charge Transfer.

Conjugated polymers are deemed as conductive carrier mediators for engendering the π electrons along the molecular framework, while the role of nonconjugated insulated polymers has been generally overlooked without the capability to participate in the solar-powered oxidation-reduction kinetics and charge-transfer process. Alternatively, considering the ultrashort charge lifetime and significant deficiency of metal nanocluster (NC)-based photosystems, the fine tuning of charge migration over atomically precise ultrasmall metal NCs as novel light-harvesting antennas has so far not yet been unleashed. Here, we unlock the charge-transfer capability of a nonconjugated polymer to modulate the charge flow over metal NCs (Au and Au) by such a solid-state nonconductive polymer via a conceptually new chemistry strategy by which l-glutathione (GSH)-capped gold (Au@GSH) NCs and poly(diallyl-dimethylammonium chloride) (PDDA) were alternately self-assembled on the metal oxide (MO: WO, FeO, and TiO) substrates.

Grinding enhances the magnetic hardness of heterometallic diruthenium(ii,iii) carbonates with a kagome lattice structure.

The assembly of paddle-wheel Ru building units affords a new trimetallic carbonate, CsCd(HO)[{Cd(HO)}{Ru(CO)}]·10HO (1), that contains structurally near-perfect kagome layers, {Ru(CO)}, linked by octahedral Cd(HO) into a nanoscale kagome network exhibiting ferromagnetic ordering below 3.5 K. The investigation of influences of the grinding method on the crystal samples of compound 1 reveals that the coercivity increases from ∼2.