Publications by authors named "Jing Xuan"

Objectives: To investigate the correlation of serum levels of bridging integrating factor 1 (BIN1) with acute myocardial infarction (AMI) and Killip class of the patients.

Methods: We retrospectively collected the data from 94 patients with AMI and 30 healthy individuals for analysis of the correlations of serum BIN1 levels with Killip class, TIMI scores, and neutrophil-to-lymphocyte ratio (NLR). We also assessed the diagnostic value of BIN1 combined with NLR for AMI.

View Article and Find Full Text PDF

Background: N6-methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing a pivotal role in various biological functions. Its significance in female reproductive development and associated diseases has recently become a focal point of research.

Objective: This review aims to consolidate current knowledge of the role of m6A modification in female reproductive tissues, emphasizing its regulatory dynamics, functional significance, and implications in reproductive health and disease.

View Article and Find Full Text PDF

It is widely accepted that repetitive elements (REs) represent the primary mechanism driving genome size variation across eukaryotes. The observed genome sizes and REs of 59 species within the Acrididae were obtained and characterized. The genome sizes observed ranged from 6.

View Article and Find Full Text PDF

Inflammation affects the pathology of wound healing and is strongly associated with many chronic wounds that do not heal. Natural herbs with anti-inflammatory effects have received much attention in clinical treatment because they are inexpensive, readily available, safe, and effective. In this study, EUO-NAC-CDs were prepared using a hydrothermal method in which Eucommia ulmoides (EUO) and n-acetylcysteine (NAC) were used as carbon sources.

View Article and Find Full Text PDF
Article Synopsis
  • NUMTs (nuclear mitochondrial pseudogenes) are segments of mitochondrial DNA that have integrated into the nuclear genome, providing a unique window into evolutionary patterns.
  • The study examined NUMTs in ten Orthoptera species, revealing divergence rates between NUMTs and current mitochondrial DNA ranging from 0% to 23.78%, with a significant link between NUMT insertions and transposable elements.
  • A proposed mechanism for NUMT integration involves the reverse transcription of mitochondrial RNA into DNA, which occurs at low probabilities, while phylogenetic analysis of NUMTs and current mtDNA offers insights into historical evolutionary processes and species relationships.
View Article and Find Full Text PDF
Article Synopsis
  • Myocardial ischemia-reperfusion injury (MIRI) often occurs during acute myocardial infarction (AMI) when doctors restore blood flow to save heart tissue, but it leads to poor healing and high mortality rates.
  • There are currently no effective preventive measures for MIRI, but research is showing that ferroptosis, a type of regulated cell death linked to iron overload and reactive oxygen species, is significant in its development.
  • This review explores the molecular and metabolic pathways involved in ferroptosis within the context of MIRI, aiming to enhance understanding of the underlying mechanisms and inspire new treatment strategies.
View Article and Find Full Text PDF

Functional dyspepsia (FD) is a brain-gut interaction disorder located in the stomach and duodenum, which has complex pathophysiological mechanisms, and there is no effective treatment for FD. Acupuncture and moxibustion have been proven to have definite and significant efficacy on FD. Focusing on the affected area and combined with the potential pathophysiology of FD, here we discuss the possible mechanisms of acupuncture and moxibustion in treating FD to guide future clinical and experimental research.

View Article and Find Full Text PDF

Premature ovarian insufficiency (POI) is defined as onset of menopause characterized by amenorrhea, hypergonadotropism, and hypoestrogenism, before the age of 40 years. The POI is increasing, which seriously affects the quality of patients' life. Due to its diversity of pathogenic factors, complex pathogenesis and limited treatment methods, the search for finding effective treatment of POI has become a hotspot.

View Article and Find Full Text PDF

Severe fracture non-union often accompanied by damaged or even absent periosteum remains a significant challenge. This paper presents a novel tri-layer bionic periosteum with gradient structure and mineralized collagen (MC) mimics natural periosteum for in-situ repair and bone regeneration. The construct with ultrasonic polylactic acid as the loose outer fibrous layer (UPLA), poly(ε-caprolactone) as the intermediate barrier layer (PCL-M), and poly(ε-caprolactone)/MC as the inner osteoblastic layer (PM) was prepared.

View Article and Find Full Text PDF
Article Synopsis
  • * A case study of a 17-year-old girl reveals she had signs of CAH, including altered external genitalia and an adrenal tumor, with elevated cortisol and androgen levels but normal 17-OHP levels.
  • * The findings suggest that undiagnosed classic CAH could lead to functional adrenal tumors, and gene testing for CYP21A2 mutations is recommended in similar clinical situations.
View Article and Find Full Text PDF

Oecanthus is a genus of cricket known for its distinctive chirping and distributed across major zoogeographical regions worldwide. This study focuses on Oecanthus rufescens, and conducts a comprehensive examination of its genome through genome sequencing technologies and bioinformatic analysis. A high-quality chromosome-level genome of O.

View Article and Find Full Text PDF

Abnormal relaxation and contraction of intestinal smooth muscle can cause various intestinal diseases. Diarrhea is a common and important public health problem worldwide in epidemiology. Zingiber officinale Roscoe (fresh ginger) has been found to treat diarrhea, but the material basis and mechanism of action that inhibits intestinal peristalsis remain unclear.

View Article and Find Full Text PDF

An essential factor in tooth nutritional deficits and aberrant root growth is pulp necrosis. Removing inflammatory or necrotic pulp tissue and replacing it with an inert material are the most widely used therapeutic concepts of endodontic treatment. However, pulp loss can lead to discoloration, increased fracture risk, and the reinfection of the damaged tooth.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how exosomes containing microRNAs from mesenchymal stem cells can reduce inflammation in the central nervous system associated with interstitial cystitis/bladder pain syndrome (IC/BPS).
  • Researchers used various scientific methods to explore the role of the TLR4 and NLRP3 inflammasome in bladder pain and to evaluate the therapeutic potential of these exosomes.
  • Results showed that injecting miR-9-enriched exosomes into mice effectively reduced neuroinflammation and bladder pain by suppressing a specific signaling pathway in the brain, suggesting a promising treatment for bladder pain linked to cystitis.
View Article and Find Full Text PDF

Oral and maxillofacial diseases are one of the most prevalent diseases in the world, which not only seriously affect the health of patients' oral and maxillofacial tissues, but also bring serious economic and psychological burdens to patients. Therefore, oral and maxillofacial diseases require effective treatment. Traditional treatments have limited effects.

View Article and Find Full Text PDF

Background: Unilateral twin ectopic pregnancy is extremely rare in natural pregnancy, with an incidence rate of only 1 in 200,000-2,500,000, represents a major health risk for reproductive-aged women, leading to even life-threatening complications. There is a lack of data on the prevalence of this rare disease after in-vitro fertilization-embryo transfer (IVF-ET) cycles.

Case Report: We present a case of a 51-year-old woman with rare unilateral twin ectopic pregnancy after frozen embryo transfer treated with bilateral salpingectomy, followed by a review of the literature.

View Article and Find Full Text PDF

Since the microgap between implant and surrounding connective tissue creates the pass for pathogen invasion, sustained pathological stimuli can accelerate macrophage-mediated inflammation, therefore affecting peri-implant tissue regeneration and aggravate peri-implantitis. As the transmucosal component of implant, the abutment therefore needs to be biofunctionalized to repair the gingival barrier. Here, a mussel-bioinspired implant abutment coating containing tannic acid (TA), cerium and minocycline (TA-Ce-Mino) is reported.

View Article and Find Full Text PDF

Type 2 diabetes (T2D) is a multifactorial complex chronic disease with a high prevalence worldwide, and Type 2 diabetes patients with different comorbidities often present multiple phenotypes in the clinic. Thus, there is a pressing need to improve understanding of the complexity of the clinical Type 2 diabetes population to help identify more accurate disease subtypes for personalized treatment. Here, utilizing the traditional Chinese medicine (TCM) clinical electronic medical records (EMRs) of 2137 Type 2 diabetes inpatients, we followed a heterogeneous medical record network (HEMnet) framework to construct heterogeneous medical record networks by integrating the clinical features from the electronic medical records, molecular interaction networks and domain knowledge.

View Article and Find Full Text PDF

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as a new mode of intercellular crosstalk and are responsible for many of the therapeutic effects of MSCs. To promote the application of MSC-EVs, recent studies have focused on the manipulation of MSCs to improve the production of EVs and EV-mediated activities. The current paper details an optimization method using non-invasive low-intensity pulsed ultrasound (LIPUS) as the stimulation for improving oral MSC-EV production and effectiveness.

View Article and Find Full Text PDF

Background: Adaptations by arthropod pests to host plant defenses of crops determine their impacts on agricultural production. The larval host range of western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae), is restricted to maize and a few grasses. Resistance of D.

View Article and Find Full Text PDF

Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate (4-OI) is a cell-permeable itaconate derivative and has been recognized as a promising therapeutic target for the treatment of inflammatory diseases. Here, we explored, for the first time, the protective effect of 4-OI on inhibiting periodontal destruction, ameliorating local inflammation, and the underlying mechanism in periodontitis.

View Article and Find Full Text PDF

Quality cost framework (QCF), as a measurement tool and research method, has played a significant role on quality improvement procedure (QIP) and recognition on economics of quality. The four general QCFs are usually conceptually employed assist quality managers to measure the quality cost (QC/COQ) including PAF, intangible loss, process cost, and ABC framework. The question of how to select an appropriate quality cost framework for individual organization is of great significance for implementing quality improvement activities.

View Article and Find Full Text PDF

The regeneration of bone defects in patients with diabetes mellitus (DM) is remarkably impaired by hyperglycemia and over-expressed proinflammatory cytokines, proteinases (such as matrix metalloproteinases, MMPs), etc. In view of the fact that exosomes represent a promising nanomaterial, herein, we reported the excellent capacity of stem cells from apical papilla-derived exosomes (SCAP-Exo) to facilitate angiogenesis and osteogenesis whether in normal or diabetic conditions . Then, a bioresponsive polyethylene glycol (PEG)/DNA hybrid hydrogel was developed to support a controllable release of SCAP-Exo for diabetic bone defects.

View Article and Find Full Text PDF

Background: Doxorubicin (DOX) is one of the most effective chemotherapeutic agents available; however, its use is limited by the risk of serious cardiotoxicity. Danshensu (DSS), an active ingredient in Salvia , has multiple cardioprotective effects, but the effect of DSS on DOX-induced cardiotoxicity has not been reported.

Objectives: Predicting the targets of DOX-induced cardiotoxicity and validating the protective effects and mechanisms of DSS.

View Article and Find Full Text PDF