Publications by authors named "Jing Xuan Lim"
Regulatory T cells (Tregs) are immune regulatory T cells that are vital for controlling inflammation. The role of Tregs in inflammatory diseases namely psoriatic arthritis (PsA) is still poorly understood. The underlying reason being a lack of robust unbiased analysis to test the immune regulatory phenotype of human Tregs.
View Article and Find Full Text PDFArticle Synopsis
- The text discusses the increasing importance of optical recording for studying molecular dynamics in biology, aided by advancements in biosensors and microscopy.* -
- It introduces AQuA2, a new data analysis platform powered by machine learning, designed to accurately and efficiently analyze complex data from live imaging.* -
- AQuA2 enables the identification of molecular activities and functional units, with applications demonstrated in various biological contexts, such as studying neuron and astroglia interactions and signal patterns in mouse spinal cords.*
Background: Mutations in the TP53 gene are the most common among genetic alterations in human cancers, resulting in the formation of mutant p53 protein (mutp53). Mutp53 promotes proliferation, migration, invasion, and metastasis in cancer cells. Not only does the initiation of oncogenesis ensue due to mutp53, but resistance towards chemotherapy and radiotherapy in cancer cells also occurs.
View Article and Find Full Text PDFInnate lymphoid cells (ILCs) play a key role in tissue-mediated immunity and can be controlled by coreceptor signaling. Here, we define a subset of ILCs that are TbetNK1.1 and are present within the tumor microenvironment (TME).
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed new calcium indicators called 'jGCaMP8' that improve the detection of neural activity in real-time, addressing the limitations of current protein sensors that report slower than electrical signaling.* -
- jGCaMP8 indicators were created using large-scale screening and targeted mutations, resulting in ultra-fast response times (half-rise times of just 2 ms) and high sensitivity to calcium changes in neurons.* -
- This advancement allows for the tracking of larger groups of neurons at speeds that align better with how quickly neural computations occur, enhancing our understanding of brain activity.*
The motivation to eat is not only shaped by nutrition but also competed by external stimuli including pain. How the mouse hypothalamus, the feeding regulation center, integrates nociceptive inputs to modulate feeding is unclear. Within the key nociception relay center parabrachial nucleus (PBN), we demonstrated that neurons projecting to the lateral hypothalamus (PBN) are nociceptive yet distinct from danger-encoding central amygdala-projecting (PBN) neurons.
View Article and Find Full Text PDF