Research progress on the effects of sedentary behavior and physical activity on diabetes mellitus.

Diabetes mellitus (DM) has become one of the most serious and common chronic diseases around the world, leading to various complications and a reduction in life expectancy. Increased sedentary behavior (SB) and decreased physical activity (PA) are important contributors to the rising prevalence of DM. This article reviews the research progress on the pathogenesis of DM, the effects of SB and PA on the risk of DM, aiming to explore the influence of different PA intensities, amounts, frequencies, durations and types on the incidence of DM.

Autophagy enhances the antibacterial response in Macrobrachium rosenbergii by modulating cellular metabolism and immune pathways.

Autophagy plays a crucial role in innate and adaptive immunity against invading microorganisms. However, the mechanism underlying autophagy in Macrobrachium rosenbergii remains largely unknown. Here, we demonstrate that Aeromonas hydrophila activates autophagy in M.

Functionalized gelatin/poly(l-lactide-co-ε-caprolactone) fibrous membrane promotes scarless wound healing by modulating inflammation and reducing fibrosis.

In cases of deep skin defects, spontaneous tissue regeneration and excessive collagen deposition can result in the formation of proliferative scarring. Salvianolic acid B (SAB) demonstrates promising applications in the treatment of fibrotic diseases, including scarring. This study prepared biodegradable gelatin (Gel) and poly(lactic-co-ε-caprolactone) (PLCL) nanofibrous membranes using electrospinning technology and functionalized them with salvianolic acid B to create fibrous membrane dressings with anti-scarring properties.

Longitudinal cross-lagged association between posttraumatic stress disorder, post-traumatic growth, and deliberate rumination among healthcare staff 2 years after the COVID-19 pandemic in Hubei Province, China.

Background: Post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG) are inspiratory areas of psychological research in which deliberate rumination has important implications. However, these relationships have not yet been assessed in the COVID-19 pandemic using longitudinal designs.

Methods: In this study, measures of PTSD, PTG, and deliberate rumination were collected from 2,292 healthcare staff members at two-time points six months apart in 2022-2023 from two general hospitals in Hubei Province, China.

ORANGE proteins mediate adaptation to high light and resistance to Pseudomonas syringae in tomato by regulating chlorophylls and carotenoids accumulation.

Chlorophylls and carotenoids are crucial for photosynthesis and plant survival, with ORANGE (OR) protein being pivotal in pigment accumulation. Despite tomato being rich in carotenoids, the roles of OR proteins in tomato have been overlooked. Herein, we characterized two OR genes in tomato, SlOR and SlOR-like, which are highly expressed in stems, leaves, and flowers, with their proteins being localized to chloroplasts.

Two novel alleles of the MYB transcription factor and control leaf trichomes and enhance resistance to aphids in .

Leaf trichome formation is a very important agronomic trait as it confers resistance to biotic and abiotic stresses, but the causal genes involved in this process in remain largely unexplored. In this study, we first characterized the haplotypes of among different inbred lines with leaf trichomes or glabrous leaves. A comparative analysis of the number and density of leaf trichomes between the two mustard inbred lines was then performed BSA analysis of leaves with trichomes and glabrous pools from the F2 segregating population mapped the candidate genes on Chr.

Prototype Matching Learning for Incomplete Multi-view Clustering.

As information acquisition diversifies, data is acquired and stored in increasing modalities. However, sensor failures or equipment issues can lead to partial data loss in certain views, resulting in incomplete multi-view clustering (IMVC) problems. Although some prototype-based IMVC methods have achieved satisfactory performance, almost all of these methods implicitly assume that the cross-view prototypes are aligned.

The hypoglycemic effect of mulberry () fruit lacking fructose and glucose by regulation of the gut microbiota.

Mulberries are known to be rich in hypoglycemic active substances such as anthocyanins and dietary fiber, which primarily aid in regulating gut microbiota. However, their high sugar content, such as fructose, hinders their application in hypoglycemic functional foods. This research utilized microbial fermentation technology to remove the fructose and glucose in mulberries (FM), subsequently evaluating their hypoglycemic properties and balancing gut microbiota.

PSMD14-mediated deubiquitination of CARM1 facilitates the proliferation and metastasis of hepatocellular carcinoma by inducing the transcriptional activation of FERMT1.

Hepatocellular carcinoma (HCC) is a highly potent malignancy. The enzyme coactivator-associated arginine methyltransferase 1 (CARM1) is highly expressed in different types of cancer. However, the precise levels of expression, clinical significance, biological functions, and molecular mechanisms of CARM1 in HCC, particularly related to the downstream genes regulated by CARM1 through histone arginine methylation, remain unclear.

A Comprehensive Review of Advanced Lactate Biosensor Materials, Methods, and Applications in Modern Healthcare.

Lactate is a key metabolite in cellular respiration, and elevated levels usually indicate tissue hypoxia or metabolic dysregulation. The real-time detection of lactate levels is particularly important in situations such as exercise, shock, severe trauma, and tissue injury. Conventional lactate assays are insufficient to address today's complex and variable testing environments, and thus, there is an urgent need for highly sensitive biosensors.

New Insight into a Green Process for Iron Manganese Ore Utilization: Efficient Separation of Manganese and Iron Based on Phase Reconstruction by Vanadium Recycle.

The difficulty of separating iron and manganese is a bottleneck issue in the traditional utilization process of iron manganese ore (Fe-Mn ore). In this work, ammonium polyvanadate (APV), an intermediate product in the vanadium industry, was introduced innovatively to convert the manganese-containing phase in Fe-Mn ore into manganese pyrovanadate (MnVO) and iron and manganese were then separated efficiently through the acid leaching process. The migration of manganese, iron, and vanadium were systematically studied through XRD, SEM, and leaching experiments.

Lactate promotes the epithelial-mesenchymal transition of liver cancer cells via TWIST1 lactylation.

Elevated lactate levels increase the risk of liver cancer progression. However, the mechanisms by which lactate promotes liver cancer progression remain poorly understood. Epithelial-mesenchymal transition (EMT), characterized by the loss of epithelial cells polarity and cell-cell adhesion, leading to the acquisition of mesenchymal-like phenotypes, is widely recognized as a key contributor to liver cancer progression.

GC-MSCs transcriptionally upregulate SALL4 in gastric cancer through miR-4669/TIMP3/β-catenin signaling.

Backgrounds: Gastric cancer-associated mesenchymal stem cells (GC-MSCs) as integral components of the tumor microenvironment potentiate gastric cancer growth and metastasis. SALL4 is aberrantly upregulated in gastric cancer and pivotal for malignant progression. Whether GC-MSCs is responsible for SALL4 upregulation and the underlying mechanisms remains elusive.

The knowledge, attitude, and practice toward fall prevention of parturients in the obstetric inpatient wards: a comparative cross-sectional study between nurses and parturients.

Objective: This study aimed to compare the knowledge, attitudes, and practices of parturients and nurses regarding fall prevention among parturients, with the goal of understanding the cognitive factors contributing to post-delivery fall.

Methods: A cross-sectional survey was conducted among obstetric nurses and women in obstetric ward within 2 days after vaginal delivery. The survey instrument included a self-design questionnaire comprising a demographic information sheet and a KAP questionnaire, which demonstrated acceptable reliability and validity.

The Efficacy of Ultrasound-Guided Selective Nerve Block in the Endovascular Treatment of Arteriovenous Fistulas.

Introduction Delivering requisite anesthesia for endovascular treatment of dysfunctional arteriovenous fistulas (AVFs) under a targeted nerve block can achieve reasonable analgesia. We evaluated the efficacy and safety of ultrasound-guided selective nerve block during percutaneous transluminal angioplasty (PTA) of dysfunctional arteriovenous access. Methods 246 patients with dysfunctional radiocephalic arteriovenous fistula undergoing PTA were enrolled in this prospective, randomized controlled trial at the Department of Nephrology, Haidian Hospital, Peking University Third Hospital from June 1, 2022 to August 31, 2023.

PfPAH1-1 gene enhances plant tolerance to low phosphate stress by modulating cell membrane lipid remodeling.

Phosphate (Pi) is an essential macroelement for plant survival, and Pi deficiency triggers membrane lipid remodeling that promotes the conversion of phospholipids to galactolipids. Perilla frutescens is a traditional food and medicinal plant, widely used in food, pharmaceutical, and industrial sectors. Importantly, Perilla seed oil is rich in polyunsaturated fatty acids (PUFAs) and are considered an ideal source of healthy vegetables oils for humans.

Physicochemical, antioxidant, gastrointestinal digestion and probiotic growth promoting properties of water and alkali extracted polysaccharides from Schizophyllum commune.

Background: Schizophyllum commune is a traditional edible and medicinal mushroom that has been successfully artificially cultivated in China. Polysaccharides from S. commune have attracted much attention because of their bioactivity.

Large-scale acoustic single cell trapping and selective releasing.

Recent advancements in single-cell analysis have underscored the need for precise isolation and manipulation of individual cells. Traditional techniques for single-cell manipulation are often limited by the number of cells that can be parallel trapped and processed and usually require complex devices or instruments to operate. Here, we introduce an acoustic microfluidic platform that efficiently traps and selectively releases individual cells using spherical air cavities embedded in a polydimethylsiloxane (PDMS) substrate for large scale manipulation.

Excision of HIV-1 Provirus in Human Primary Cells with Nanocapsuled TALEN Proteins.

Despite the tremendous success of combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV) infection, the durability and persistence of latent reservoirs of HIV-infected cells in HIV-infected patients remain obstacles to achieving HIV cure. While technically challenging, the most direct means to eradicate latent reservoirs is to destroy the HIV provirus, thus ensuring that HIV virions are not produced while preserving resident cells. Transcription activator-like effector nucleases (TALEN)─a genome editing method with high DNA targeting efficiency─have been investigated as a potential gene therapy by disrupting the HIV-1 coreceptor CCR5 genes in HIV target cells or HIV proviral DNA in infected cells.

Unravelling OsPHT2;1 function in Chloroplast Phosphorus Homeostasis and Photosynthetic Efficiency under Low Phosphorus Stress in Rice.

Phosphorus (P) deficiency is a critical factor limiting crop productivity, primarily due to its detrimental effects on photosynthesis and dry matter accumulation. In this study, we investigate the role of the rice gene OsPHT2;1 in mediating chloroplast P homeostasis and its subsequent impact on photosynthetic function under low P conditions. Stomatal conductance is typically positively correlated with net photosynthetic rates; however, P deficiency disrupts this relationship, leading to reduced stomatal opening and diminished photosynthetic efficiency.

Efficacy and Safety of New Oral Anticoagulants versus Warfarin in the Resolution of Atrial Fibrillation with Left Atrial/Left Atrial Appendage Thrombus: A Systematic Review and Meta-Analysis.

Background: To compare the efficacy and safety of novel oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) in nonvalvular atrial fibrillation (NVAF) patients with left atrial/left atrial thrombosis through a systematic review and meta-analysis.

Methods: The CBM (China Biology Medicine disc), CNKI (China National Knowledge Infrastructure), VIP (Chinese Technology Periodical Database), Wanfang, PubMed, Embase, Cochrane Library, and Web of Science databases were searched for relevant studies from their inception to June 30, 2022.

Results: Twelve articles (eight cohort studies and four randomized controlled trials) involving 982 patients were included.

Cost-Effective Day Surgery for Arteriovenous Fistula Stenosis: A Viable Model for Hemodialysis Patients.

BACKGROUND For patients with end-stage renal disease, arteriovenous fistulas (AVFs) are often used for hemodialysis, but stenosis can impair their function. Traditional inpatient procedures to address AVF stenosis are effective but resource-intensive, prompting the need for alternative approaches like day surgery to optimize care and reduce costs. This study evaluated the feasibility of a day surgery model for AVF stenosis treatment in maintenance hemodialysis (MHD) patients, aiming to develop a cost-effective and high-quality care model.

Effects of Glycerol Monooleate on Improving Quality Characteristics and Baking Performance of Frozen Dough Breads.

This study investigated the impact of glycerol monooleate (MO) at varying levels (0.3%, 0.6%, 0.

The PDR-type ABC transporter OsPDR1 is involved in leaf senescence by influencing melatonin biosynthesis in rice.

Leaf senescence is a complex developmental process that is regulated by multiple genetic and environmental factors. Understanding the mechanisms underlying the regulation of leaf senescence will provide valuable insights for manipulation of this trait in crops. Here, we report that the ATP-binding cassette (ABC) transporter OsPDR1 is involved in promoting leaf senescence in rice.

Narcolepsy in early childhood: a case report and a Mini review.

Narcolepsy is a sleep-wake disorder with an onset commonly seen in individuals aged 10-30 years. Due to various reasons, the diagnosis of narcolepsy often experiences a delay of at least ten years. Diagnosing narcolepsy in children is particularly challenging due to atypical symptoms, leading to frequent misdiagnosis or missed diagnoses.