Per- and polyfluoroalkyl substances and type 2 diabetes among older adults: Synthesizing cross-sectional population study and meta-analysis.

The effects of per- and polyfluoroalkyl substances (PFASs) on type 2 diabetes (T2D) remain unclear. We aimed to explore the effects of PFASs exposure on glucose metabolism disorders in older adults. We enrolled 704 elderly individuals aged over 65 years from Wuhan, China.

Internet-Based Cognitive Behavioral Therapy for Preventing Postpartum Depressive Symptoms Among Pregnant Individuals With Depression: Multicenter Randomized Controlled Trial in China.

Background: Women are particularly vulnerable to depression during pregnancy, which is one of the strongest risk factors for developing postpartum depression (PPD). Addressing antenatal depressive symptoms in these women is crucial for preventing PPD. However, little is known about the effectiveness of internet-based cognitive behavioral therapy (ICBT) in preventing PPD in this high-risk group.

Deciphering novel enzymatic and non-enzymatic lysine lactylation in .

Lysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria. Here, we identified 1,090 lactylation sites on 469 proteins by mass spectrometry in Typhimurium.

The resveratrol attenuates reactive oxygen species mediated DNA damage in cardiac malformations caused by 4-tert-octylphenol.

4-tert-octylphenol (4-t-OP) is an alkylphenolic environmental endocrine disruptor extensively distributed in the environment, posing potential hazards to living organisms. Research has demonstrated that 4-t-OP induces cardiac injury and abnormalities in embryonic development, which can adversely affect heart development. The excessive production of reactive oxygen species (ROS) triggered by 4-t-OP may result in DNA damage.

Histone lactylation protects against sevoflurane-induced cognitive impairment by regulating YTHDF3/PRDX3 mediated microglial pyroptosis in neonatal mice.

Background: Sevoflurane (SEV), a widely used inhalational anesthetic, multiple SEV exposures has been implicated in cognitive impairment, particularly in neonates. However, the mechanisms underlying SEV-induced cognitive impairment not fully understood.

Methods: Neonatal mice or murine microglial line BV-2 cells were exposed to SEV.

utilizes L-arabinose to silence virulence gene expression for accelerated pathogen growth within the host.

Carbon source is an important nutrient for bacteria to sustain growth and often acts as a signal that modulates virulence expression. L-arabinose is produced by plants and plays an important role in regulating the global gene expression of bacteria. Previously, we have shown that L-arabinose induces a more severe systemic infection in -infected mice with normal microbiota, but does not affect the disease progression in mice with microbiota depleted by antibiotic treatment.

Family Support Moderates the Relationship Between Pregnancy Stress, Depressive Symptoms, and Insomnia.

Objective: Insomnia is a common issue that pregnant women often have to deal with. This study seeks to examine the connections between pregnancy stress, depressive symptoms, family support, and insomnia symptoms.

Methods: Convenience sampling was employed to recruit 1049 valid participants.

Case report: A rare case of chondrosarcoma-like malignant giant cell tumor in adolescent rib: diagnostic challenges and treatment.

Chondrosarcoma-like malignant giant cell tumor (GCT) of the rib is an extremely rare and aggressive tumor, particularly in adolescents. This case report describes a 19-year-old female presenting with a GCT of the rib with chondrosarcomatous differentiation, highlighting the challenges posed by its unusual location and pathological complexity. Multidisciplinary diagnostic approaches, including advanced imaging, immunohistochemistry (IHC), and pathology, were essential for confirming the diagnosis.

Integrating single-cell RNA-seq and bulk RNA-seq to explore prognostic value and immune landscapes of methionine metabolism-related signature in breast cancer.

Background: Neoadjuvant, endocrine, and targeted therapies have significantly improved the prognosis of breast cancer (BC). However, due to the high heterogeneity of cancer, some patients cannot benefit from existing treatments. Increasing evidence suggests that amino acids and their metabolites can alter the tumor malignant behavior through reshaping tumor microenvironment and regulation of immune cell function.

Advanced EPISM approach for holographic stereogram generation utilizing neural radiance fields.

This paper presents a synthetic holographic stereogram printing approach that integrates neural radiance fields (NeRF) with the effective perspective images segmentation and mosaicking (EPISM) method. Sparse perspectives of a 3D scene are captured through random sampling and used to train a NeRF model with multi-resolution hash encoding, enabling rapid construction of an implicit scene representation. The EPISM method calculates the camera pose parameters needed for parallax images, which are rendered through the trained neural network.

Polymer Ligands with Multi-Nitrogen Heterocyclic Carbenes for Enhanced Stability and Reactivity in Nanoparticle Surface Functionalization.

Nitrogen heterocyclic carbenes (NHCs) are emerging as effective substitutes for conventional thiol ligands in surface functionalization of nanoparticles (NPs), offering exceptional stability to NPs under harsh conditions. However, the highly reactive feature of NHCs limits their use in introducing chemically active groups onto the NP surface. Herein, we develop a general yet robust strategy for the efficient surface functionalization of NPs with copolymer ligands bearing various functional groups.

Synergistic effect of synthetic phenolic antioxidant exposure and overweight/obesity on altered sex hormone levels: Normoglycemic rural Chinese population.

The widespread use of synthetic phenolic antioxidants (SPAs) has led to their ubiquity and may contribute to multiple adverse health outcomes by affecting hormone level disruption. This study aimed to assess the exposure levels of SPAs in the plasma of the normoglycemic rural Chinese population, investigate the association of single and mixed pollutant exposures with sex hormones, and analyze the moderating role of body mass index (BMI) in these relationships. A cross-sectional study including 763 individuals with normal blood glucose from the Henan Rural cohort was conducted.

Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection.

As an opportunistic pathogen, Pseudomonas aeruginosa can cause both acute and chronic infections that are notoriously difficult to treat. However, the mechanism underlying acute or chronic P. aeruginosa infection remains unclear.

Trichoderma virens XZ11-1 producing siderophores inhibits the infection of Fusarium oxysporum and promotes plant growth in banana plants.

Background: Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense is a soil-borne fungal disease.

Enhanced piezoelectric sensor to distinguish real-time arrhythmia for predicting heart failure.

Monitoring cardiac rhythm is crucial for diagnosis of heart failure. However, the deficient sensitivity of polyvinylidene fluoride (PVDF) sensors impede their application in monitoring of cardiac rhythm due to the limited piezoelectricity. Here, doping of CoFeO and aligning fibers were jointly adopted to enhance the piezoelectricity of PVDF, attributed to the transformation of α-PVDF to β-PVDF from 51.

Repetitive Transcranial Magnetic Stimulation and Tai Chi Chuan for Older Adults With Sleep Disorders and Mild Cognitive Impairment: A Randomized Clinical Trial.

Importance: Sleep disorders and mild cognitive impairment (MCI) commonly coexist in older adults, increasing their risk of developing dementia. Long-term tai chi chuan has been proven to improve sleep quality in older adults. However, their adherence to extended training regimens can be challenging.

Transcriptome analysis identifies key genes in juvenile hormone and ecdysteroid signaling pathways and their roles in regulating reproductive system development of adult Monochamus saltuarius.

Monochamus saltuarius is an important vector of pinewood nematode in Eurasia with a high reproductive capacity. Endocrine hormones play a key role in insect reproduction. Understanding the mechanism of internal regulation can provide targets for pest control.

Efficient Cytosolic Delivery of Single-Chain Polymeric Artificial Enzymes for Intracellular Catalysis and Chemo-Dynamic Therapy.

Designing artificial enzymes for in vivo catalysis presents a great challenge due to biomacromolecule contamination, poor biodistribution, and insufficient substrate interaction. Herein, we developed single-chain polymeric nanoparticles with Cu/N-heterocyclic carbene active sites (SCNP-Cu) to function as peroxidase mimics for in vivo catalysis and chemo-dynamic therapy (CDT). Compared with the enzyme mimics based on unfolded linear polymer scaffold and multichain cross-linked scaffold, SCNP-Cu exhibits improved tumor accumulation and CDT efficiency both in vitro and in vivo.

BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation.

Cognitive impairment is a significant complication of type 2 diabetes mellitus (T2DM). However, the mechanisms underlying the development of cognitive dysfunction in individuals with T2DM remain elusive. Herein, we discussed the role of Bmal1, a core circadian rhythm-regulating gene, in the process of T2DM-associated cognitive dysfunction.

Generation of Multiple-Depth 3D Computer-Generated Holograms from 2D-Image-Datasets Trained CNN.

Generating computer-generated holograms (CGHs) for 3D scenes by learning-based methods can reconstruct arbitrary 3D scenes with higher quality and faster speed. However, the homogenization and difficulty of obtaining 3D high-resolution datasets seriously limit the generalization ability of the model. A novel approach is proposed to train 3D encoding models based on convolutional neural networks (CNNs) using 2D image datasets.

Molecular structure of polysaccharide mediated autophagy markers KIF23 and PRC1 proteins and their regulatory role in triple negative cancer through the p53 signaling pathway.

As a process of intracellular degradation and recycling of its own components, abnormal regulation of autophagy has been strongly associated with the development of multiple cancer types, including triple-negative breast cancer. The amino acid sequences of KIF23 and PRC1 proteins were analyzed by bioinformatics method, their three-dimensional structures were predicted, and their interactions with polysaccharides were studied by molecular docking technology. The localization and expression patterns of KIF23 and PRC1 in cells were studied by cell biology techniques.

Multiple effects of kisspeptin on neuroendocrine, reproduction, and metabolism in polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a highly prevalent and heterogeneous disease characterized by a combination of reproductive and endocrine abnormalities, often associated with metabolic and mental health disorders. The etiology and pathogenesis of PCOS remain unclear, but recent research has increasingly focused on the upstream mechanisms underlying its development. Among these, kisspeptin (KISS) signaling has emerged as a pivotal component in the regulation of the hypothalamic-pituitary-gonadal axis, with significant roles in reproductive function, energy regulation, and metabolism.

Ultrasound-Activated Precise Sono-Immunotherapy for Breast Cancer with Reduced Pulmonary Fibrosis.

Immune checkpoint inhibitors have demonstrated remarkable efficacy across various cancer types. However, immune-related adverse events (irAEs) pose a significant challenge in immunotherapy, particularly the associated pneumonia as the primary adverse reaction, which can lead to irreversible pulmonary fibrosis. Additionally, monotherapy with programmed death ligand (PD-L1) inhibitors has shown limited effectiveness.

Nanoparticle-enabled In Situ drug potency activation for enhanced tumor-specific therapy.

Cancer treatment faces significant challenges including inadequate tumor specificity, drug resistance, and severe side effects, often resulting in unsatisfactory patient outcomes. Nanomedicines offer a transformative platform for tumor-targeted drug delivery and antitumor potency activation, providing an indispensable strategy for overcoming the severe damage to normal tissues caused by the inherent "always-on" cytotoxicity of conventional therapeutic agents. This review focuses on the emerging concept of "nanoparticle-enabled in situ drug potency activation", where inactive or minimally toxic agents are selectively activated within tumors to enhance the therapeutic efficacy and minimize the adverse effects.

Association between fatty acids and female infertility: dual evidence from a cross-sectional study and Mendelian randomization analysis.

: Infertility poses a considerable threat to female reproductive health on a global scale. Dietary pattern, as a modifiable lifestyle factor, is frequently recommended as an important intervention for infertility-related diseases. Fatty acids play a crucial role in maintaining the health of the female reproductive system.