Exploring the Mechanism of Protein for Broiler Growth Based on Gut Microbiota and Serum Metabolomics.

Intestinal health is vital for poultry production, and protein plays a key role in intestinal nutrition. The present study used 16S rRNA gene sequencing and serum metabolomics to investigate the effect of CAP on the cecal microflora structure and serum metabolites in 42-day-old broiler chickens. A total of 480 one-day-old Arbor Acres broiler chickens were randomly divided into four treatments with twelve replicates comprising 10 chickens each, evenly divided by sex.

Molecular characterization of TRAF gene family in snakehead (Channa argus).

Tumor necrosis factor receptor-associated factors (TRAFs) act as signal transducers and are critical in many biological processes. However, in contrast to mammals, the function of TRAFs in teleost is still largely unknown. In this study, we identified and cloned eight TRAF genes in snakehead (Channa argus), namely CaTRAF2aa, CaTRAF2ab, CaTRAF2b, CaTRAF3, CaTRAF4a, CaTRAF5, CaTRAF6, and CaTRAF7.

Opposite outcomes of triglyceride-glucose index and associated cardiovascular mortality risk in type 2 diabetes mellitus participants by different obesity criteria.

We investigated the correlation between Triglyceride-glucose (TyG) index and cardiovascular disease (CVD) mortality in type 2 diabetes mellitus (T2DM) population across different obesity classications using a cohort study. We analyzed 7867 T2DM participants from the National Health and Nutrition Examination Survey 1999-2018, categorizing them into obese or non-obese group by body mass index (BMI) and waist circumference (WC). Cox regression models were used to estimate the correlation between TyG index and CVD mortality risk, comparing the results across the two obesity classifications.

Effects of 3-month liraglutide treatment on oxidative stress and inflammation in type 2 diabetes patients with different urinary albumin-to-creatinine ratio categories.

This study evaluates the effects of liraglutide on albuminuria, oxidative stress, and inflammation in type 2 diabetes (T2D) patients with different urinary albumin-to-creatinine ratio (UACR) categories. We enrolled 107 patients with T2D who were initiating liraglutide for glycemic control. Patients were categorized into 3 groups: group I (UACR < 30 mg/g); group II (30 mg/g ≤ UACR ≤ 300 mg/g); group III (UACR > 300 mg/g).

The regulatory role of integrin in gastric cancer tumor microenvironment and drug resistance.

Gastric cancer (GC) remains a significant global health burden due to its high aggressiveness, early metastasis, and poor prognosis. Despite advances in chemotherapy and targeted therapies, drug resistance remains a major obstacle to improving patient outcomes. Integrins, a family of transmembrane receptors, play a pivotal role in mediating tumor growth, invasion, and drug resistance by interacting with the tumor microenvironment (TME) and regulating signaling pathways such as Wnt/β-catenin, FAK, and MAPK.

Video-Based Plastic Bag Grabbing Action Recognition: A New Video Dataset and a Comparative Study of Baseline Models.

Recognizing the action of plastic bag taking from CCTV video footage represents a highly specialized and niche challenge within the broader domain of action video classification. To address this challenge, our paper introduces a novel benchmark video dataset specifically curated for the task of identifying the action of grabbing a plastic bag. Additionally, we propose and evaluate three distinct baseline approaches.

Effect of Temperature and Stress on Creep Behavior of (TiB + TiC + YO)/α-Ti Composite.

In this study, a (TiB + TiC + YO)/α-Ti composite was prepared by induction skull melting to investigate its creep behavior and microstructure evolution under different temperatures and stresses. The results show that the microstructure of the composite in the as-cast state is a basket-weave structure, and the main phase composition is α lamella, containing a small amount of β phase and equiaxed α phase. The creep life of the composite decreases significantly when the temperature is increased from 650 °C to 700 °C, and the steady-state creep rate is increased by 1 to 2 orders of magnitude.

Integrated analysis of miRNAs and mRNAs in thousands of single cells.

The simultaneous sequencing of multiple types of biomolecules can facilitate understanding various forms of regulation occurring in cells. Cosequencing of miRNA and mRNA at single-cell resolution is challenging, and to date, only a few such studies (examining a quite limited number of cells) have been reported. Here, we developed a parallel single-cell small RNA and mRNA coprofiling method (PSCSR-seq V2) that enables miRNA and mRNA coexpression analysis in many cells.

Probabilistic Attention Map: A Probabilistic Attention Mechanism for Convolutional Neural Networks.

The attention mechanism is essential to (CNN) vision backbones used for sensing and imaging systems. Conventional attention modules are designed heuristically, relying heavily on empirical tuning. To tackle the challenge of designing attention mechanisms, this paper proposes a novel probabilistic attention mechanism.

Whole-tree harvesting improves the ecosystem N, P and K cycling functions in secondary forests in the Qinling Mountains, China.

Forest ecosystem nutrient cycling functions are the basis for the survival and development of organisms, and play an important role in maintaining the forest structural and functional stability. However, the response of forest nutrient cycling functions at the ecosystem level to whole-tree harvesting remains unclear. Herein, we calculated the ecosystem nitrogen (N), phosphorus (P), and potassium (K) absorption, utilization, retention, cycle, surplus, accumulation, productivity, turnover and return parameters and constructed N, P, and K cycling function indexes to identify the changes in ecosystem N, P, and K cycling functions in a secondary forest in the Qinling Mountains after 5 years of five different thinning intensities (0% (CK), 15%, 30%, 45%, and 60%).

Comparison of leaf anatomical structure and photosynthetic characteristics between weedy rice and cultivated rice at the seedling stage.

To explore the internal factors related to the strong growth and competitive ability of weedy rice during the seedling period, we collected two biotypes of Japonica weedy rice from Northeast China, four biotypes of Indica weedy rice from Eastern China and Southern China, and two biotypes of cultivated rice, Zhendao-8 (ZD-8) and Shanyou-63 (SY-63), which were used as controls in a pot experiment. Under homogeneous garden planting conditions, we measured the vascular bundle size (VBS), vascular bundle number (VBN), leaf thickness (LT), air cavity size (ACS), stomatal size (SS), stomatal density (SD), net photosynthetic rate (Pn) and stomatal conductance (Gs) of the weedy and cultivated rice biotypes. A comprehensive analysis was performed to explore the correlation between the seedling leaf structure and the photosynthetic indices of the biotypes.

Associations between endogenous sex hormones and multisite chronic musculoskeletal pain.

Background: Sex-differences in pain perception have been documented; however, the role of sex hormones in chronic musculoskeletal pain (CMP) remains unclear. Therefore, this study investigated whether sex hormones and sex hormone-binding globulin (SHBG) are associated with CMP.

Methods: We utilised data from the UK Biobank (n=357 424; females: 51.

A preliminary exploration of the synergistic preservation effect of electrostatic field and superchilling on muscle foods: Mechanisms, influencing factors, applications, and challenges.

Muscle foods that are highly perishable require effective preservation technologies to maintain their quality and extend their shelf life. Electrostatic field (EF) treatment, superchilling (SC), and their combined technologies have received attention for their effectiveness in improving muscle food quality. However, the lack of a comprehensive understanding of their mechanism and combined effects on muscle foods has limited their application.

KAHA ligation as a platform for the rapid discovery of Protein Tyrosine phosphatase 1B (PTP1B) inhibitors.

We have successfully designed and assembled a 66-member library of protein tyrosine phosphatases (PTP) inhibitor candidates using α-ketoacid-hydroxylamine (KAHA) ligation. Subsequent in situ enzymatic screening revealed a potent hit (IC = 1.67 μM) against PTP1B, which displayed 6.

The chain-mediating effects of negative physical sensation and experiential avoidance on exercise anxiety in college students.

Purpose: The present study aimed to explore the potential mediating role of negative physical sensation and experiential avoidance in the association between endurance exercise and exercise anxiety among university students.

Method: In this study, a questionnaire method was employed to conduct the Adolescent Athlete Non-Intellectual Factors Survey Scale on 1,200 college students. From this sample, 287 individuals with exercise anxiety were identified through an endurance exercise test and the Acceptance and Action Questionnaire (AAQ-II) subsequently administered as well as The Borg Rating of Perceived Exertion (RPE).

Integrated microbiomic and metabolomic dynamics of Yi traditional fermented liquor.

This study examines the microbial community composition, metabolite characteristics, and the relationship between the two during the fermentation process of Yi traditional fermented liquor. Yi traditional fermented foods have a profound historical and cultural background, with significant ethnic characteristics. As a case in point, Yi traditional fermented liquor is typically prepared using local plants or traditional Chinese herbs as fermentation substrates and undergoes a lengthy fermentation process, resulting in a fermented beverage that is reputed to have beneficial effects on human health.

Cascading tipping points of Antarctica and the Southern Ocean.

Antarctica and the Southern Ocean are key elements in the physical and biological Earth system. Human-induced climate change, and other human activities in the region, are leading to several potential interacting tipping points with major and irreversible consequences. Here, we examine eight potential physical, biological, chemical, and social Antarctic tipping points.

Delayed immune-related adverse events profile associated with immune checkpoint inhibitors: a real-world analysis.

Background: Immune-related adverse events (irAEs) typically occur within 3 months of initiating immune-checkpoint inhibitors (ICIs), which has been extensively documented. But the clinical profiles of late-onset irAEs remain inadequately characterized. Therefore, this study aims to quantify the correlation between delayed irAEs and ICIs, and to delineate the profiles of delayed toxicities associated with ICIs using data from the Food and Drug Administration Adverse Event Reporting System (FAERS).

Exploration the effective components of Gastrodia elata in improving cerebral ischemia reperfusion injury based on "Spectrum-effect" correlation and zebrafish verification experiment.

Background: Gastrodia elata (GE) has been widely used in clinical practice for many years with the functions of relieving stroke, suppressing liver Yang, dispelling wind and clearing collaterals. Our group's previous experimental studies have proved that GE has therapeutic effect on cerebral ischemia reperfusion injury (CIRI) (Ding et al., 2022).