Field Demonstration of In Situ Remediation of Contaminated Groundwater Using Ozone Micro-Nano-Bubble-Enhanced Oxidation.

The ozone micro-nano-bubble-enhanced oxidation (OMNBEO) technology has shown great potential for organics-contaminated groundwater remediation in laboratory studies. However, few studies addressed its effectiveness in engineering practices as well as the impact on the groundwater environment. In this study, a field demonstration was conducted to investigate the efficiency of OMNBEO in remediating groundwater contaminated by various organic compounds.

A unique presentation of systolic anterior motion of the mitral valve in a patient with obstructive hypertrophic cardiomyopathy and recurrent syncope: a case report.

Background: Systolic anterior motion (SAM) of the mitral valve is a hallmark feature of hypertrophic obstructive cardiomyopathy (HOCM) and a primary cause of dynamic left ventricular outflow tract obstruction. This case report highlights an unusual presentation of SAM associated with acute haemodynamic collapse.

Case Summary: A 36-year-old male with HOCM presented with recurrent episodes of syncope.

Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis.

Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential of gallic acid (GA)-derived PGA-Cu nanoparticles, enhanced with functional octapeptide (Cys-Lys-His-Gly-d-Arg-d-Tyr-Lys-Phe, SS08) to build the mitochondria-targeted nanoparticles (PGA-Cu@SS08), and embedded within a hydrogel matrix to form a nanocomposite hydrogel, is explored.

Radioresistance in Hepatocellular Carcinoma: Biological Bases and Therapeutic Implications.

Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality. Radiotherapy technology is a common treatment modality that can be used in all stages of HCC. However, in some cases, radiotherapy fails in clinical practice mainly because of the patient's resistance to radiotherapy, creating a bottleneck for future breakthroughs.

Analysis of synonymous codon usage bias in the chloroplast genome of five Caragana.

Background: The genus Caragana, known for its adaptability and high forage value, is commonly planted to rehabilitate barren land and prevent desertification. Several Caragana species are also used for medicinal purposes. Analysis of synonymous codon usage bias and their primary influencing factors in chloroplast genomes aims to provide insights into molecular research and germplasm innovation for Caragana plants.

Fecal microbiota transplantation mitigates postdieting weight regain in mice by modulating the gut-liver axis.

Background: Dysbiosis of the microbiome is strongly associated with weight rebound after dieting. However, the interactions between the host and microbiome and their relevance to the pathogenesis of post-diet weight rebound remain unclear.

Purpose: This study aimed to evaluate the effects of fecal microbiota transplantation (FMT) on post-diet weight regain and to investigate the underlying mechanisms by which FMT inhibits weight regain.

The Anti-PEDV Effects and Mechanisms of Forsythia Essential Oil Based on Network Pharmacology and Experimental Validation.

Objective: Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae, is responsible for acute diarrhea, vomiting, and dehydration, which can lead to high mortality in neonatal piglets. Previous research has indicated the antiviral potential of forsythia essential oil (FEO); however, its active components and mechanisms of action remain inadequately defined. This study aims to investigate the antiviral effects of FEO and elucidate its potential mechanisms for treating PEDV.

Maternal Decision-Making in Non-Mother Caregiving Negotiation for Infants in Black-and-White Snub-Nosed Monkeys (Rhinopithecus bieti).

Allomaternal care, or caregiving by non-maternal individuals, is prevalent in primates, yet few studies have explored the role of maternal consent and decision-making during this process. This study introduces the concept of "non-mother caregiving negotiation", highlighting the mother's primary role in deciding on non-maternal caregiving. This study focuses on a semi-provisioned breeding band of black-and-white snub-nosed monkeys (Rhinopithecus bieti) in the Xiangguqing area of the Baimaxueshan National Nature Reserve.

"Integrated Stacked" Design "Nanobullet" for High Photothermal Conversion in Dual-Mode Lateral Flow Immunoassay.

(), a prevalent foodborne bacterium, necessitates creating sensitive and rapid detection methods for food safety, with lateral flow immunoassays (LFIAs) using nanomaterials as signal tracers being particularly effective. Enhancements in performance and sensitivity are not restricted to the material alone, we propose an "integrated stacked" concept, which combines amorphous active sites, hollow morphology for enhanced reflection, and symmetric structure for strong absorption resonance. This approach leads to significant photothermal enhancement (η = 60.

A Facile Method for Preparing Fluorinated Poly(aryl ether)s Toward High-Frequency Low Dielectric Materials.

Two fluorinated monomers M1 and M2 based on pentafluorostyrene, are synthesized via an aromatic nucleophilic substitution reaction (SNAr) at room temperature, with high yields of up to 90%. Subsequently, M1 and M2 are converted to fluorinated poly(aryl ether)s through thermo-crosslinking. Among the two polymers, cured M2 possessing higher fluorine content, demonstrates superior overall performance with a 5% weight loss temperature (T) of 465 °C, a low water uptake of 0.

Factorial Mendelian randomization of lipoprotein (a) lowering, low-density lipoprotein cholesterol lowering, and lifestyle improvements: joint associations with cardiovascular risk.

Background: High levels of lipoprotein(a) [Lp(a)] have been associated with an increased risk of cardiovascular disease (CVD); however, the effects of Lp(a)-lowering therapy in combination with low-density lipoprotein cholesterol (LDL-C)-lowering treatment or lifestyle improvements on CVD risk remain unexplored.

Methods: We conducted a factorial Mendelian randomization study among 385 917 participants in the UK Biobank. Separate genetic scores were constructed to proxy the effects of Lp(a) lowering, LDL-C lowering through different targets [HMG-CoA reductase, NPC1-like intracellular cholesterol transporter 1, proprotein convertase subtilisin/kexin Type 9, and low-density lipoprotein receptor (LDLR)], as well as improvements in body mass index (BMI), systolic blood pressure (SBP), and lifestyle factors (cigarette smoking, alcohol consumption, and physical activity).

Efficient construction of spirocyclopentane-1,3-dioxindoles an annulation reaction of isocyanides and 3-methyleneoxindoles.

The DABCO-promoted annulation reaction of alkyl isocyanides with two 3-methyleneoxindole molecules in refluxing acetonitrile afforded functionalized dispiro[indoline-3,1'-cyclopentane-3',3''-indolines] in moderate yields and with a variety of diastereoselectivities through a cascade [2 + 2 + 1] cycloaddition reaction. However, the DABCO-promoted annulation reaction of 3-(2-isocyanoethyl)indole and 3-phenacylideneoxindoles gave unique polycyclic spiro[indoline-3,5'-pyrrolo[3',2':2,3]cyclopenta[1,2-]indoles] in satisfactory yields and with high diastereoselectivity.

Photothermal functionalized antibacterial packaging film with controllable release capability for fruit preservation.

The traditional contact release active packaging film is easily restricted by the strict storage environment and designing a more intelligent release system to achieve lasting food preservation is still a challenge. Herein, a light-responsive thermal-controlled curcumin release packaging film was fabricated by integrating chitosan with Cu-MoO and curcumin (CS/CMC). The addition of filler did not destroy the crystal structure and thermal stability of the chitosan matrix.

Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer.

Conventional neoadjuvant chemotherapy provides limited benefit for patients with resectable non-small cell lung cancer (NSCLC). Recently, neoadjuvant chemoimmunotherapy (NCIT) has transformed the perioperative management of NSCLC by priming systemic anti-tumor immunity before surgery, yet it remains ineffective for at least 50% of patients. Through single-cell sequencing analysis of our NCIT cohort, we identify that antigen-presenting cancer-associated fibroblasts (apCAFs) can impede the efficacy of NCIT.

Safety and efficacy of a fitusiran antithrombin-based dose regimen in people with hemophilia A or B: the ATLAS-OLE study.

Fitusiran, a subcutaneous investigational siRNA therapeutic, lowers antithrombin (AT) to increase thrombin generation and rebalance hemostasis in people with hemophilia. This phase 3 open-label extension study (ATLAS‑OLE, NCT03754790) evaluated safety and efficacy of antithrombin-based dose regimen (AT-DR) in males ≥ 12 years with severe hemophilia A/B, with/without inhibitors. The original 80 mg monthly (QM) dose regimen (ODR) was optimized to AT-DR targeting AT activity levels 15-35% to mitigate thrombotic risk (starting dose 50 mg once every 2 months [Q2M], individually adjusted to 20 mg Q2M or 20/50/80 mg QM as needed).

Cognitive function and mortality among persons aging with HIV and injection drug use.

Objective: Cognitive impairment and frailty are critical aging-related phenotypes prevalent among people living with HIV (PLWH). Yet, limited data exist isolating the determinants of cognitive function among persons with a history of injection drug use (PWID) with and at risk for HIV, or on the intersecting relationship of cognitive function and frailty with mortality in this population.

Design/methods: Standard cognitive assessments were performed among PWID with and without HIV in the AIDS Linked to the IntraVenous Experience (ALIVE) cohort.

Efficacy and Safety of Recombinant Factor VIII in Previously Untreated and Previously Treated Children with Hemophilia A: A Systematic Review.

Introduction: Inhibitor development is a primary concern for pediatric patients with hemophilia A (HA) undergoing recombinant factor VIII (rFVIII) therapy, yet relevant research is lacking. We aimed to compare the efficacy and safety of standard (SHL) and extended half-life (EHL) rFVIII products in previously treated (PTPs) and untreated (PUPs) pediatric patients with HA.

Methods: Following PRISMA guidelines, we searched clinical studies from PubMed, Embase, and Cochrane Library.

Nitrogen and phosphorus fertilizer use efficiency improves alfalfa ( L.) production and performance in alkaline desert soil.

The deficiency of nitrogen and phosphorus is a primary constraint on the normal growth of alfalfa ( L.) in the alkaline desert soils of northern Xinjiang. Optimizing the combination of nitrogen and phosphorus fertilizers can maximally significantly enhance farmers' economic returns while concurrently mitigate soil environmental pollution.

Integrating Radiosensitivity Index and Radiation Resistance Related Index Improves Prostate Cancer Outcome Prediction.

Purpose: This study aimed to establish a nomogram combining 31-gene signature (31-GS), radiosensitivity index (RSI), and radiation-resistance-related gene index (RRRI) to predict recurrence in prostate cancer (PCa) patients.

Methods And Materials: Transcriptome data of PCa were obtained from gene expression omnibus and the cancer genome atlas to validate the predictive potential of 3 sets of published biomarkers, namely, 31-GS, RSI, and RRRI. To adjust these markers for the characteristics of PCa, we analyzed 4 PCa-associated radiosensitivity predictive indices based on 31-GS, RSI, and RRRI by the Cox analysis and least absolute shrinkage and selection operator regression analysis.

Dual Functional Radioactive Gel-Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma.

Transarterial radioembolization (TARE) is an established clinical therapy for treating patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who cannot undergo radical treatment. However, the delivery of a high radiation dose is associated with several adverse effects, such as radiation pneumonitis. Additionally, the available radioactive microspheres (MSs) are dense and unsuitable for interventional delivery.

Novel anti-inflammatory compounds that alleviate experimental autoimmune encephalomyelitis.

Background: Multiple sclerosis (MS) is an autoimmune disease primarily characterized by inflammatory demyelination. Despite significant research efforts, effective therapies for MS remain limited. Drug screening offers a promising approach to rapidly identifying potential therapeutic compounds.

Trajectory of gut microbiota before and after pediatric cardiopulmonary bypass surgery.

Background: Varied congenital heart disease (CHD) may induce gut microbiota dysbiosis due to intestinal hypoperfusion or/and hypoxemia. Microbiota dysbiosis has been found in preoperative infants and cardiopulmonary bypass (CPB) exacerbated it further. However, the trajectory of gut microbiota from pre- to early post-CPB and one-year later remains unexplored.

Application of a Value Framework to Determine the Value of Prophylaxis Versus On-Demand Treatment in Adults with Hemophilia A in China.

Introduction: This study aimed to establish and apply a multicriteria value framework to determine the value of prophylaxis versus on‑demand treatment in adult patients with hemophilia A in China, which could enhance evidence-based care decisions.

Methods: The framework was developed using key literature to identify dimensions and indicators for assessing the value of hemophilia A. We interviewed 21 stakeholders-including clinical experts, medical insurance experts, health economics and outcomes research (HEOR) experts, charity organization representatives, and patient advocacy organization representatives-to evaluate the relative importance of indicators.