Symmetrical femtosecond laser arc incision in correcting corneal astigmatism in cataract patients.

Aim: To evaluate the effect of symmetrical arc incision correcting corneal astigmatism in femtosecond laser-assisted phacoemulsification (FLACS).

Methods: This study enrolled patients with cataract combined with regular corneal astigmatism of >0.75 D, who underwent FLACS.

FLACS combined with IOLI is comparable to Phaco combined with IOLI in cataract patients after refractive surgery.

Objective: To characterize the clinical features of cataract surgery performed after refractive surgery.

Methods: In this study, 23 patients with cataracts (38 eyes) who underwent cataract surgery following refractive surgery at the Shenzhen Aier Eye Hospital between the years 2017 and 2021 were retrospectively included for analysis. The patients had either femtosecond laser-assisted cataract surgery (FLACS) combined with intraocular lens implantation (IOLI), or conventional phacoemulsification (Phaco) combined with IOLI.

Effects of Ultrasound Contrast Agent-Mediated Nerve Growth Factor on Apoptosis of Retinal Ganglion Cells in Mice with Glaucoma.

With an increasing incidence in recent years, glaucoma (GL) has gradually become a global public health problem for humans of all ages. Nerve growth factor (NGF) eye drops, with well-documented stable effect in the treatment of GL, can be potentiated by the administration of NGF drugs via ultrasound contrast agent (UCA). This study analyzed the efficacy of NGF+UCA on GL mice and the influencing mechanism on retinal ganglion cells and further explored the pathological changes of GL mice under different UCA irradiation duration.

Trifocal diffractive intraocular lens implantation in patients after previous corneal refractive laser surgery for myopia.

Background: With the difficulties in IOL power calculation and the potential side effects occurring postoperatively, multifocal IOL implantation after previous corneal refractive surgery are rarely reported especially for the trifocal IOL. Herein we report the clinical observation of trifocal IOL implantation in patients with previous myopia excimer laser correction. In this study, a multi-formula average method was performed for the IOLs power calculation to improve the accuracy.

Clinical research of intraoperative image-guidance in endoscopic nasocular operation.

Aim: To evaluate the availability and our experience of intraoperative image-guidance in endoscopic nasocular operation.

Methods: Seven cases of endoscopic nasal surgery with intraoperative image-guidance were retropectively reviewed, including 3 cases of optic nerve injury; 3 cases of foreign object of optic behind the eyeball; 1 case of retrobulbar tumor (angeioma).

Results: The preoperative preparatory time would take 15 minutes, including coordination, head holder localization, conventional instrument registration.

Study of the influence of angiostatin intravitreal injection on vascular leakage in retina and iris of the experimental diabetic rats.

Purpose: To examine the effect of an intravitreal injection of angiostatin on vascular leakage in retina and iris of the diabetes and study its possible mechanism.

Methods: Experimental diabetes was induced in 24 rats by an intravenous injection of streptozotocin (STZ) during 48 adult rats. Three groups were randomization distributed of them.

Systemic and periocular deliveries of plasminogen kringle 5 reduce vascular leakage in rat models of oxygen-induced retinopathy and diabetes.

Purpose: Increased retinal vascular permeability is a common complication of diabetes and a major cause of vision loss in diabetic patients. The current study is to determine the effect of plasminogen kringle 5 (K5) on vascular leakage via systemic and periocular deliveries.

Methods: Oxygen-induced retinopathy (OIR) was generated by exposing newborn rats to 75% oxygen.

[The application of naphcon eye drops during Lasik surgery].

Purpose: To evaluate the effects of Naphcon eye drops for preventing conjunctival bleeding during Lasik surgery.

Methods: One hundred cases (200 eyes) were divided into treating group and control group randomly according to using and not using Naphcon eye drops before Lasik surgery. Treating group patients received three times Naphcon eye drops during 15 minutes before surgery.

Genetic difference in susceptibility to the blood-retina barrier breakdown in diabetes and oxygen-induced retinopathy.

The breakdown of the blood-retina barrier (BRB) is a common feature of diabetic retinopathy. The purpose of the present study is to determine whether there are genetic differences in susceptibility to the breakdown of the BRB in diabetic retinopathy using two rat models. In streptozotocin (STZ)-induced diabetes, Brown Norway (BN) rats developed sustained vascular hyperpermeability in the retina during the entire experimental period (16 weeks of diabetes), while diabetic Sprague Dawley (SD) rats only showed retinal hyperpermeability from 3 to 10 days after the onset of diabetes.

Suppression of corneal neovascularization by PEDF release from human amniotic membranes.

Purpose: Human amniotic membrane (HAM) transplantation is commonly used in corneal surface reconstruction and is known to inhibit neovascularization of this tissue. The purpose of the present study is to reveal the molecular basis underlying antiangiogenic activity of HAM.

Methods: The effects of HAM protein on proliferation of vascular endothelial cells and corneal epithelial cells were determined by quantifying viable cells using the MTT assay.

The effect of angiostatin on vascular leakage and VEGF expression in rat retina.

Angiostatin is a potent angiogenic inhibitor. The present study identified a new activity of angiostatin: reducing vascular leakage, which is associated with diabetic macular edema, tumor growth and inflammation. An intravitreal injection of angiostatin significantly reduced retinal vascular permeability in rats with oxygen-induced retinopathy and in those with streptozotocin-induced diabetes, but not in normal rats.

Decreased pigment epithelium-derived factor and increased vascular endothelial growth factor levels in pterygia.

Purpose: Pterygia are histologically composed of proliferating fibrovascular tissue. This study compared expression levels of an angiogenic inhibitor, pigment epithelium-derived factor (PEDF), in pterygia with those in normal corneal and conjunctival tissues.

Methods: The normal human conjunctival and corneal tissues were obtained from surgery or from donor eyes without ocular diseases.