Therapeutic effects of conditioned medium from bone marrow-derived mesenchymal stem cells on epithelial-mesenchymal transition in A549 cells.

Pulmonary fibrosis (PF) is a chronic lung disease. The transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis. Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to be a modulator of the molecular aspects of the fibrosis pathway.

[Effect of N-acetyl-seryl-aspartyl-lysyl-proline on regulation of expression of ras-raf-ERK1/2 signal transduction pathway in lung of rats with silicosis].

Objective: to investigate the effect of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) on the expressions of c-Raf, ERK1/2 and TGF-β1 in the lung of rats with silicosis, thus to investigate the regulating of AcSDKP on the Ras-Raf-ERK1/2 signal transduction pathway.

Methods: rats were instilled with silica through trachea as silicotic models and administered AcSDKP in the experiment. Rats were divided into 6 groups randomly, 10 rats in each group: Control 1 and 2 of silicotic model: each rat was intratracheally instilled with 1.

Electro-optical response of the in-plane switching liquid crystal device fabricated using two-easy-axes substrate.

We investigate the electro-optical response of an in-plane switching (IPS) liquid crystal (LC) device, which is fabricated using the two-easy-axes substrate. The two-easy-axes substrate is fabricated by slightly rubbing the substrate in two different directions. Experimental results indicate that the IPS LC device fabricated using the two-easy-axes substrate has a lower threshold voltage and a faster response time than the traditional IPS LC device, which is fabricated using the unidirectionally rubbed substrate.