The burden and trends of depressive disorders in adolescent and young adults aged 15-29 in China, 1990-2021 and its prediction to 2030: Findings from the Global Burden of Disease Study 2021.

Background: Depressive disorders (DDs) are the leading causes of disability among adolescents and young adults (AYAs) in China. This study estimated the trends of DDs burden among AYAs in China over the last 32 years, and further predicted to 2030.

Methods: Based on the Global Burden of Disease Study 2021, age-standardized incidence, prevalence, and years lived with disability (YLDs) rates were used to describe the DDs burden among AYAs (aged 15-29 years) in China.

Conditioned medium of engineering macrophages combined with soluble microneedles promote diabetic wound healing.

Diabetic wounds have a profound effect on both the physical and psychological health of patients, highlighting the urgent necessity for novel treatment strategies and materials. Macrophages are vital contributors to tissue repair mechanisms. Macrophage conditioned medium contains various proteins and cytokines related to wound healing, indicating its potential to improve recovery from diabetic wound.

Air plasma assisted directional electrodeposition of Ag nanoparticles on carbon cloth for electrochemical detection of rutin.

The air plasma-induced defects and O-related groups are employed as anchoring sites for the directional electrochemical deposition of Ag nanoparticles (AgNPs) with even distribution and a narrow size range on carbon cloth (CC). The strategy of integrating the air plasma and AgNPs provides plentiful adsorption and catalytic sites, a large electroactive area, superhydrophilic interface, and a smooth charge and mass-transfer pathway. As a consequence, the fabricated self-supporting electrode of AgNPs@CC - P displays an excellent sensing performance toward rutin with a large linear concentration window (0.

Study on the Temporal Patterns of CA1 Pyramidal Neuron Activity in Mice Hippocampus under Simulated Spaceflight Composite Environment.

With the gradual realization of manned spaceflight goals, the physical and mental health of astronauts has become a core concern. Numerous studies in recent years have indicated that the aerospace special environment (ASE) can lead to alterations in astronaut cognitive function. However, the adaptive changes in neuronal activity underlying these alterations remain unclear.

Transcriptomic Study of Neural Regulation in the Medial Prefrontal Cortex of Depressive Mice with Low-Intensity Focused Ultrasound.

Exploring new effective treatments for depression holds important social significance and clinical value. Low-intensity focused ultrasound stimulation (LIFUS) has been proven to have significant neuroprotective effects on depression. However, the specific genes regulated by LIFUS in depressive mice remain unclear.

Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma.

Aims: Temozolomide (TMZ) is the first-line chemotherapeutic agent for glioblastoma (GBM) therapy; however, resistance to TMZ remains a major obstacle in GBM treatment. The aim of this study is to elucidate the mechanisms underlying TMZ resistance and explore how to enhance the sensitivity of GBM to TMZ.

Methods: GBM organoids were generated from patient samples, and organoid-based TMZ sensitivity testing was performed.

Enhanced N-Butanol Sensing Performance of Cr-Doped CeO Nanomaterials.

The Cr-doped CeO nanomaterials were prepared by a simple hydrothermal method. Morphological analysis revealed that Cr doping altered the morphology and size of the CeO particles. Gas sensing tests results showed that Cr/Ce-2 has the highest response (/ = 15.

Trustworthy diagnosis of Electrocardiography signals based on out-of-distribution detection.

Cardiovascular disease is one of the most dangerous conditions, posing a significant threat to daily health. Electrocardiography (ECG) is crucial for heart health monitoring. It plays a pivotal role in early heart disease detection, heart function assessment, and guiding treatments.

Standard dose could be better! A multicenter study of tigecycline in patients with liver failure.

Background: High-dose (HD) tigecycline is often required for severe multidrug-resistant gram-negative infections in liver failure patients, despite package recommendations to halve the dose for those with severe liver impairment. This study evaluated the efficacy and safety of different tigecycline doses in this population.

Research Design And Methods: A retrospective cohort of 192 patients with Child-Pugh grade C liver failure was divided into label-dose (LD), standard-dose (SD), and HD groups.

Control of Rhizobia Endosymbiosis by Coupling ER Expansion with Enhanced UPR.

Legumes establish symbiosis with rhizobia by forming a symbiotic interface that enables cross-kingdom exchanges of signaling molecules and nutrients. However, how host organelles interact with symbiosomes at the symbiotic interface remains elusive during rhizobia endosymbiosis. Here, symbiotic cells are reconstructed using 3D scanning electron microscopy (SEM) and uncover that the host endoplasmic reticulum (ER) undergoes dynamic expansion to gradually enwrap symbiosomes, facilitating their compartmentalization and endosymbiosis.

Dextran from human feces-derived Weissella cibaria facilitates intestinal mucosal barrier function by modulating gut bacteria and propionate levels.

The disruption of the intestinal mucosal barrier is strongly associated with the onset of various diseases, including inflammatory bowel disease. Exopolysaccharides (EPS) support the functionality of the intestinal barrier. Weissella Cibaria (W.

Synergistic cryoprotective effects of mannan oligosaccharides and curdlan on the grass carp surimi.

The cryoprotective effects of mannan oligosaccharides (MOS) and curdlan (CU) on the quality of grass carp surimi after freeze-thaw cycles (FTCs) were assessed using the response surface methodology. The optimal contents of MOS (6.79 %, /w) and CU (0.

Inoculation with autochthonous yeast strains in Harbin dry sausages with partial substitution of NaCl by KCl: Bacterial community structure and flavour profiles.

The effects of two autochthonous yeast strains (Pichia kudriavzevii and Debaryomyces hansenii) on the physicochemical characteristics, bacterial community structure, and flavour profile of the dry sausages with 40% substitution of NaCl by KCl were evaluated in this study. The results revealed that the inoculation of yeast strains increased the pH and yeast counts of low-sodium sausages. Higher contents of total esters, aldehydes, and ketones were detected in the inoculated sausages (P < 0.

SECTM1 acts as an immune-related biomarker of poor prognosis and promotes cancer progression by modulating M2 macrophage polarization in esophageal squamous cell carcinoma.

Esophageal squamous cell carcinoma (ESCC) is the most prevalent primary malignant esophageal tumor in China and has a poor prognosis, but lacks effective diagnostic and prognostic biomarkers. Through single-sample gene set enrichment analysis (ssGSEA), we conducted immune genomic analysis based on 28 immune features using transcriptomic data from 155 ESCC cases. We established of two ESCC subtypes characterized by high and low immune profiles, and 352 differentially expressed immune genes were identified between the two subtypes.

Comparative efficacy of cetuximab combined with FOLFOX or CAPEOX in first-line treatment of RAS/BRAF wild-type metastatic colorectal cancer: a multicenter case-control study.

FOLFOX combined with cetuximab is a recommended first-line treatment regimen for RAS/BRAF wild-type metastatic colorectal cancer (mCRC). CAPEOX combined with cetuximab differs from the FOLFOX regimen by using oral capecitabine instead of continuous infusion of fluorouracil, offering greater convenience and cost-effectiveness with higher patient acceptance. However, the comparative efficacy of these two regimens remains debatable, necessitating further evidence to explore any differences in their efficacy.

A machine learning-based radiomics approach for differentiating patellofemoral osteoarthritis from non-patellofemoral osteoarthritis using Q-Dixon MRI.

This prospective diagnostic study aimed to assess the utility of machine learning-based quadriceps fat pad (QFP) radiomics in distinguishing patellofemoral osteoarthritis (PFOA) from non-PFOA using Q-Dixon MRI in patients presenting with anterior knee pain. This diagnostic accuracy study retrospectively analyzed data from 215 patients (mean age: 54.2 ± 11.

Identification and Screening of Trace and Multityped Solvents Using Transpiration-Driven Electrokinetic Generation Principle.

Transpiration-driven electrokinetic power generators (TEPGs) hold promising potential for intelligent chemical sensing applications, enabling the efficient identification and screening of organic solvents. Here, we report a novel TEPG-based chemical sensor using MoS-doped cellulose filter paper for efficient detection of poplar solvents like water, alcohols, and methanol. TEPGs operate by leveraging capillary-driven transpiration to induce solvent flow through porous materials, leading to ion migration and the formation of electrical double layers (EDLs) at the solid-liquid interfaces.

Is place-based supportive policy necessary to reduce corporate emissions? Firm-level evidence from China.

Although a considerable body of research has documented the effects of environmental regulation, spatially differentiated sustainability pressures in China call for diversified environmental governance policies. Based on the Sustainable Development Policy for Resource-based Cities (SDPRC) implemented in 2007, we adopt a staggered difference-in-differences approach using firm-level data to investigate the microeffects and mechanisms of place-based supportive policy on corporate emissions. We find strong and robust evidence that the SDPRC has significantly reduced corporate emissions.

Optimizing Biomimetic 3D Disordered Fibrous Network Structures for Lightweight, High-Strength Materials via Deep Reinforcement Learning.

3D disordered fibrous network structures (3D-DFNS), such as cytoskeletons, collagen matrices, and spider webs, exhibit remarkable material efficiency, lightweight properties, and mechanical adaptability. Despite their widespread in nature, the integration into engineered materials is limited by the lack of study on their complex architectures. This study addresses the challenge by investigating the structure-property relationships and stability of biomimetic 3D-DFNS using large datasets generated through procedural modeling, coarse-grained molecular dynamics simulations, and machine learning.

Systemic factors associated with antler growth promote complete wound healing.

Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). This regeneration process starts from regenerative healing of wounds. Removal of PP abolishes antler regeneration, however, the regenerative cutaneous wound healing proceeds, indicating that some factors in the circulation contribute to this healing.

Insights into interaction of quaternary ammonium salt cationic surfactants with different branched-chain lengths and DNA: Multi-spectral analysis, viscosity method, and gel electrophoresis.

In this study, the interactions between three quaternary ammonium salt (QAS) cationic surfactants with different branched-chain lengths (TMBAC, TEBAC, and TBBAC) and DNA are investigated by UV-vis absorption, fluorescence and CD spectroscopy, viscosity method, and gel electrophoresis. Berberine hydrochloride (BR) is utilized as a fluorescent probe. The three interaction modes and strengths are compared.

Microtopography-induced hydrological heterogeneity promotes the co-assembly of vascular plant and biocrust communities, providing synergistic protective functions for the Great Wall.

The Great Wall in China, constructed from rammed earth, faces threats from natural erosion. Vascular plants and biocrusts have enhanced the stability of the Great Wall through various mechanisms; however, understanding of the colonization processes of vascular plants and biocrusts on the wall, as well as their protective mechanisms, remains limited. This study investigated the vascular plant communities, biocrusts, soil moisture content, soil properties, aggregate mechanical stability, aggregate water stability, and soil erodibility factors across seven fine-scale microtopographies of the Great Wall (lower, middle, and upper zones on the east and west faces, as well as the wall crest).

Lactic acid/tartaric acid-maltitol antibacterial activity against spoilage bacteria and prevention of yellowing and wilting in spinach and oilseed rape.

The wilting and yellowing of leafy vegetables caused by spoilage bacteria resulted in serious resource wastage. This study investigated the efficacy of a combined lactic acid (LA) and tartaric acid (TA) treatment against four predominant spoilage bacteria (Erwinia persicina, Citrobacter freundii, Pseudomonas putida, and Pseudomonas punonensis) isolated from spinach and oilseed rape. Detailed analysis using Fourier-transform infrared spectroscopy, flow cytometry, scanning electron microscopy, and light microscopy revealed substantial cellular damage in the bacteria treated by LA and TA, including loss of intracellular material, and collapse of cellular morphology, as well as effective biofilm removal.

Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation.

Psoriasis is a chronic, systemic immune-mediated skin disease. Although many new strategies for psoriasis treatment have been developed, there is great need in clinic for treating psoriasis. Gentiopicroside (GPS), derived from Gentiana manshurica Kitagawa, has multiple pharmacological activities including anti-inflammatory, anti-oxidative and antiviral activities.