Periprosthetic Joint Infection and Concomitant Sepsis: Unveiling Clinical Manifestation, Risk Factors, and Patient Outcome.

Purpose: This study investigated the epidemiology, risk factors, and outcomes of sepsis, a life-threatening complication, in the context of periprosthetic joint infections (PJI) of the hip and knee.

Methods: Sepsis was determined using the Sepsis-1 criteria. The cohort with PJI and sepsis was compared to patients who had PJI without sepsis.

Multi-omics analysis reveals the role of UGT72 family genes in arbutin biosynthesis in Pyrus and evolution driven by whole genome duplication.

The UGT72 gene family encodes proteins that glycosylate phenylpropanoids, and thus contribute to the synthesis of various phenolic substances. However, their functional role and evolutionary history in Pyrus spp. remains poorly understood.

Sea buckthorn Flavonols extract co-loaded Zein/gum Arabic nanoparticles: Evaluating cellular absorption in Caco-2 cells and antioxidant activity in HepG2 cells.

Improving sea buckthorn flavonoids (SF) stability and bioacccessibility is of more practical significance for evaluating the total bioacccessibility of such foods. Therefore, we prepared nanoparticles using zein and gum Arabic (GA) by anti-solvent precipitation to encapsulate SF. Nanoparticles were characterized and assessed for their effect on the stability, release, bioaccessibility, absorption, and antioxidant properties of SF in the in vitro digestion and cell line.

Sleep disturbances and female infertility: a systematic review.

Background: Sleep disturbances are more prevalent among women with infertility. Current research increasingly highlights the significant relationship between sleep disturbances and female infertility, suggesting that sleep may be a key factor in reproductive health. In this review, we aim to delve into the complex interplay between sleep disturbances and female infertility, as well as to assess the underlying mechanisms involved, and seek to illuminate the causes of sleep-related fertility issues.

Does Two-level Hybrid Surgery Promote Early Fusion Compared with Two-level Anterior Cervical Discectomy and Fusion?

Background Context: Hybrid surgery (HS), which involves both anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (ACDR), is increasingly used to treat multilevel cervical disc degenerative disease, yielding satisfactory clinical outcomes. Early fusion is critical after anterior cervical fusion surgeries, but there are no studies comparing the rate of early fusion of HS with that of ACDF.

Purpose: The purpose of this study was to compare the rate of early fusion (3-6 months postoperatively) of two-level HS with that of two-level ACDF surgery.

Coptisine acts as a nucleolus fluorescent probe in vitro.

Coptisine (COP) is a natural protoberberine isoquinoline alkaloid that is isolated from Coptis chinensis and exhibits a variety of pharmacological activities, such as the inhibition of tumor growth, bacterial infection, inflammation and oxidative stress. In this study, COP penetrated and produced fluorescent signals in living tumor cell lines, primary MEF cells and polyformaldehyde-fixed cells. The fluorescent signal was detected at a wavelength of 488 nm.

Declining trends and regional variations of organophosphate ester contamination in indoor dust from mainland China: Insights from a filed study and meta-analysis.

This study investigated the presence of 20 organophosphate esters (OPEs) in indoor dust samples collected from the Chinese cities of Lanzhou, Xining, and Lhasa. The results demonstrate the ubiquitous presence of most OPEs in these three cities, with the highest concentrations of ΣOPEs found in Xining. We also summarized the occurrence of OPEs in indoor environments from 38 studies with 1875 samples collected across various regions of mainland China from 2012 to 2023.

Training machine learning models to detect rare inborn errors of metabolism (IEMs) based on GC-MS urinary metabolomics for diseases screening.

Background: Gas chromatography-mass spectrometry (GC-MS) has been shown to be a potentially efficient metabolic profiling platform in urine analysis. However, the widespread use of GC-MS for inborn errors of metabolism (IEM) screening is constrained by the rarity of IEM in population, and the difficult and specialized complexity of the interpretation of GC-MS organic acid profiles.

Methods: Based on 355,197 GC-MS test cases accumulated from 2013 to 2021 in China, a random forest-based machine learning model was proposed, trained, and evaluated.

Langerhans cell histiocytosis mimicking hematoma of the lower eyelid: A case report.

Rationale: The orbital Langerhans cell histiocytosis (LCH) is rare clinically, due to its ability to mimic other conditions, distinguishing LCH from hematoma when these disorders coexist can be particularly challenging.

Patient Concerns: A 3-year-old boy presented with a 2-week history of unresolved bruising and swelling of the left eye. CT revealed a well-defined cystic lesion in the preseptal tissues of the left eyelid, with an incomplete bone structure at the lower margin of the orbit.

Boosting Photovoltaic Efficiency: The Role of Functional Group Distribution in Perovskite Film Passivation.

The utilization of small organic molecules with appropriate functional groups and geometric configurations for surface passivation is essential for achieving efficient and stable perovskite solar cells (PSCs). In this study, two isomers, 4-sulfonamidobenzoic acid (4-SA) and 3-sulfamobenzoic acid (3-SA), both featuring sulfanilamide and carboxyl functional groups arranged in different positions, are evaluated for their effectiveness in passivating defects of the perovskite layer. The calculation and characterization results reveal that 3-SA, with its meta-substitution, offered superior passivation compared to the para-substituted 4-SA, leading to enhanced charge carrier dynamics and extraction efficiency.

Triacylphosphines as a Novel Class of Phosphorus Sources for the Synthesis of Transition Metal Phosphide Nanoparticles.

Transition metal phosphide (TMP) nanoparticles (NPs) are versatile materials for energy conversion/storage applications due to their robustness and many possibilities to tailor NPs' electronic, physical, and chemical properties. One of the hurdles toward their broader implementation is their challenging synthesis exacerbated by the limited choice of phosphorus precursors. On the one hand, the synthesis of TMP NPs can employ various alkyl- or arylphosphines requiring prolonged heating at high temperatures, while on the other hand, highly reactive P(SiMe), white phosphorus, or PH pose additional obstacles associated with their hazardous nature, high cost, and limited availability.

Unveiling the link: anti-protein disulfide isomerase A3 autoantibody expression and polycystic ovary syndrome risk in euthyroid autoimmune thyroiditis women.

Background: Polycystic ovary syndrome (PCOS) is a common complication of autoimmune thyroiditis (AIT) in women, but the underlying mechanism remains unclear. Protein disulfide isomerase A3 (PDIA3) is a ubiquitous protein. We have reported that PDIA3 autoantibody (PDIA3Ab) production results from autoimmune responses against thyrocytes, resulting in its high expression in euthyroid AIT patients.

Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation.

Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosomes-miRNA plays a crucial role in disease progression.

[Textual research on Zitan].

In recent years, with the continuous deepening of the theory of Wu Yun Liu Qi, the application of Zitan in Shenping Decoction and Shengming Decoction has gradually become widespread. Because Zitan is an imported herbal medicine, it is not commonly used in modern medicine and known as an unusual medicinal material. The unclear original plants may affect the clinical application of this medicine.

Long-term Outcomes Following Individualized Elective Primary Tumor CTV Delineation Based on Stepwise Spread Patterns of Nasopharyngeal Carcinoma Treated with Intensity-modulated Radiotherapy.

Purpose: Our institution has developed an individualized elective primary tumor clinical target volume (CTVp) delineation protocol for nasopharyngeal carcinoma (NPC) based on stepwise tumor spread patterns in intensity-modulated radiotherapy (IMRT) for over ten years. Herein, we report the long-term efficacy and toxicities in NPC patients treated under this protocol.

Methods And Materials: A total of 7,262 histologically proven, nonmetastatic NPC patients treated with IMRT following this individualized delineation protocol were retrospectively evaluated.

Oxygen promotes radical-mediated heterogeneous hygrothermal degradation of konjac glucomannan: Molecular structure and influence mechanism.

Heterogeneous hygrothermal degradation (HHTD) efficiently produces partially depolymerized konjac glucomannan (KGM). However, KGM degrades considerably faster in oxygen-containing air packaging than in oxygen-free vacuum packaging. This study investigated the effects of different atmosphere conditions on the molecular structure of KGM and the radicals involved in its degradation system.

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.

Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-dependent coupling between neuronal and synaptic excitation and mitochondrial DNA transcription (E-TC), which operates differently compared to classic excitation-transcription coupling in the nucleus (E-TC). We demonstrated that E-TC repurposes molecules traditionally associated with E-TC to regulate mitochondrial DNA expression in areas closely linked to synaptic activation.

An investigation into the zoning of ecosystem sensitivity control areas in Mentougou District (Beijing, China).

To achieve a more precise delineation of ecosystem sensitivity control areas, this study examines the Mentougou District in Beijing and introduces the Ecosystem Sensitivity Control Area Classification Method (ESCACM). This novel approach combines single-factor sensitivity analysis, multi-factor comprehensive sensitivity assessments, and strategies for zoning based on various ecological scenarios. The study categorizes the region into three specific zones: first-level management and control areas, second-level management and control areas, and non-management and control areas.

Disease burden and health inequality of older adults with edentulism and the projected trend until 2040: based on the global burden of disease study 2021.

Objectives: To comprehensively analyze the current situation and the trends over the next 21 years, focusing on health inequalities related to edentulism among the elderly across global regions.

Materials And Methods: Data on edentulism in older adults were collected from the 2021 global burden of disease (GBD) study. Disease burden trends were analyzed using a joinpoint model.

Anti-FDX1 Autoantibody as a Potential Biomarker for Non-Small Cell Lung Cancer Detection.

Background: Autoantibodies can be readily identified prior to biopsy and may serve as valuable biomarkers for cancer detection. Ferredoxin 1 (FDX1) is a key regulator in the process of cuproptosis and affects the prognosis of lung cancer. In this study, we investigated whether the anti-FDX1 autoantibody could serve as a novel biomarker for the detection of non-small cell lung cancer (NSCLC).

Characteristics of corneal aberration in patients with bilateral keratoconus and unilateral corneal Vogt's striae.

Aim: To assess the corneal high-order aberration (HOA) and its correlation with corneal morphological parameters in patients with bilateral keratoconus (KCN) and unilateral Vogt's striae.

Methods: A total of 168 eyes of 84 patients with KCN, whose corneas had definite signs of unilateral Vogt's striae, were enrolled. Corneal HOA and morphological parameters were measured using Pentacam HR.

Digoxigenin activates autophagy in hepatocellular carcinoma cells by regulating the PI3K/AKT/mTOR pathway.

Hepatocellular carcinoma (HCC) is recognized as a highly malignant tumor. Targeted combination immunotherapy, the initially approved regimen, is compromised by adverse side effects and low response rates during clinical treatment. Traditional Chinese medicine and its derived natural compounds, known for their anticancer effects, offer advantages of low toxicity and cost.

When animal viruses meet N-methyladenosine (mA) modifications: for better or worse?

N-methyladenosine (mA) is a prevalent and dynamic RNA modification, critical in regulating gene expression. Recent research has shed light on its significance in the life cycle of viruses, especially animal viruses. Depending on the context, these modifications can either enhance or inhibit the replication of viruses.

In-depth exploration of cutaneous anthrax: clinical and pathological manifestations of a case report.

Anthrax is an acute infectious disease caused by Bacillus anthracis, which can infect various animals and humans. Cutaneous anthrax primarily presents as infiltrative, edematous erythema, surface vesicles, hemorrhagic vesicles, and necrotic eschar; some patients may also experience systemic symptoms such as fever and leukocytosis. With economic development and improvements in public health conditions, naturally occurring cases of cutaneous anthrax have significantly decreased, leading to limited reports on the pathological manifestations of this disease.