Publications by authors named "Jing Lan Mu"

Article Synopsis
  • The study aimed to create a mouse model for postoperative delirium to better understand its mechanisms, using a method involving repeated clamping of the superior mesenteric artery.
  • Results showed that the induced ischemia/reperfusion (I/R) led to significant anxiety and cognitive decline in mice, with microglial activity in the brain closely linked to these behavioral changes.
  • Treatment with minocycline reduced harmful compounds linked to cognitive deficits and showed potential in managing the effects of elevated IL-6 levels on microglial activation post-surgery.
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Objective: To develop a clinical practice guideline to guide the treatment of low back pain by acupuncture.

Methods: An integrative approach of systematic review of literature, clinical evidence classification, expert opinion surveying, and consensus establishing via a Delphi program was utilized during the developing process. Both evidence-based practice standards and the personalized features of acupuncture were taken into considerations.

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Objective: The purpose of the study was to evaluate the association between motor subtypes of postoperative delirium in the intensive care unit and fast-track failure (a composite outcome of prolonged stay in the intensive care unit >48 hours, intensive care unit readmission, and 30-day mortality) after cardiac surgery.

Methods: This was a secondary analysis of a prospective cohort study of 600 consecutive adults undergoing cardiac surgery at a university hospital in Hong Kong (July 2013 to July 2015). The motor subtypes of delirium were classified using the Richmond Agitation Sedation Score and Confusion Assessment Method intensive care unit assessments performed by trained bedside nurses.

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Objectives: Postcardiac surgery delirium is associated with increased risks of morbidity, cognitive decline, poor health-related quality of life and mortality, and higher healthcare costs. We performed a systematic review of randomized controlled trials to examine the effect of pharmacologic agents for the prevention and the treatment of delirium after cardiac surgery.

Data Sources: Electronic search on PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, ISI Web of Science, and CINAHL up to December 2013.

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We investigated the effect of 1.4% isoflurane (ISO) on the development of inflammation and apoptosis caused by zymosan (ZY) in mice. We found that ZY-challenged mice exhibited significant body weight loss, markedly high mortality, and significant lung injury characterized by the deterioration of histopathology, histologic scores, and wet-to-dry ratio after ISO treatment.

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