Crotonoids A-H, Labdane-Type Diterpenoids with Anti-Inflammatory Activity from Croton Sublyratus.

Croton sublyratus (Euphorbiaceae) is a traditional medicinal plant used by the Thai populace to treat helminthic infections and dermatologic conditions. In present study, eight new labdane-type diterpenoids, crotonoids A-H (1-8) and one known analogue (9) were isolated from the aerial parts of C. sublyratus.

Value of quantitative microsurface structure analysis for evaluating the invasion depth of type 0-II early gastric cancer.

Background And Aim: The microsurface structure reflects the degree of damage to the glands, which is related to the invasion depth of early gastric cancer. To evaluate the diagnostic value of quantitative microsurface structure analysis for estimating the invasion depth of early gastric cancer.

Methods: White-light imaging and narrow-band imaging (NBI) endoscopy were used to visualize the lesions of the included patients.

[Interferon-α mediating the functional damage of CD56CD57natural killer cells in peripheral blood of systemic lupus erythematosuss].

Objective: To investigate the regulatory effect of interferon-α (IFN-α) on the apoptosis and killing function of CD56CD57 natural killer (NK) cells in systemic lupus erythematosus (SLE) patients, and to explore the specific mechanism.

Methods: A total of sixty-four newly treated SLE patients and sixteen healthy controls (HC) enrolled in the Second Hospital of Dalian Medical University were selected as the research subjects. And the gene expression levels of molecules related to NK cell-killing function were detected by real-time quantitative polymerase chain reaction.

Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1/PI3K/AKT/GLUT4 pathway.

Ethnopharmacological Relevance: Cortex fraxini (also known as qinpi)-the bark of Fraxinus rhynchophylla Hance (Oleaceae)-is widely used as a Chinese traditional medicinal for its anti-inflammatory and anti-hyperuricemic activities.

Aim Of The Study: Obesity-induced insulin resistance (IR) is driving the rising incidence of type 2 diabetes mellitus and is related to pathological adipose tissue remodeling. Esculin, a major active component of Cortex fraxini, has anti-diabetic effects.

Sublyratins A-O, Labdane-Type Diterpenoids from .

Fifteen new labdane-type diterpenoids, sublyratins A-O (-), along with four known analogues (-) were isolated from the aerial parts of . Their structural assignments were challenging due to the stereoisomeric features evident and were achieved by analyzing comprehensively the spectroscopic data and electronic circular dichroism spectra and using X-ray crystallographic analysis. Compounds and - displayed cytotoxic activity against the HL-60 cell line with IC values of 1.

Prognostic Value of Serum Apolipoprotein B to Apolipoprotein A-I Ratio in Hepatocellular Carcinoma Patients Treated with Transcatheter Arterial Chemoembolization: A Propensity Score-Matched Analysis.

Introduction: The prognosis of advanced hepatocellular carcinoma (HCC) varies in patients receiving transcatheter arterial chemoembolization (TACE). In this study, we aimed to assess the prognostic value of serum apolipoprotein B (ApoB)/apolipoprotein A-I (ApoA-I) in this group of patients.

Methods: The serum lipid levels of HCC patients undergoing TACE were obtained from routine preoperative blood lipid examination.

The Prognostic Value of aspartate aminotransferase to lymphocyte ratio and systemic immune-inflammation index for Overall Survival of Hepatocellular Carcinoma Patients Treated with palliative Treatments.

: Lymphocytes were reported to play a significant part in host anticancer immune responses and influence tumour prognosis. Few studies have focused on the prognostic values of aspartate aminotransferase (AST) to lymphocyte ratio (ALRI), aspartate aminotransferase to platelet count ratio index (APRI) and systemic immune-inflammation index (SII) in hepatocellular carcinoma (HCC) treated with palliative treatments. : Five hundred and ninety-eight HCC patients treated with palliative therapies were retrospectively analysed.

Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer.

Background: Deregulation of protein translation control is a hallmark of cancers. Eukaryotic initiation factor 4A2 (EIF4A2) is required for mRNA binding to ribosome and plays an important role in translation initiation. However, little is known about its functions in colorectal cancer (CRC).

Novel Terpenoids with Potent Cytotoxic Activities from .

A novel sesquiterpene dimer, spirocommiphorfuran A (); two new cadinane sesquiterpenoids, commiphorenes A () and B (); along with three known terpenoids (⁻), were isolated from . The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound features a 7-oxabicyclo[2.

N-containing compounds from Periplaneta americana and their activities against wound healing.

Three new compounds, periplanamides A (1) and B (2), periplanpyrazine A (3), a new naturally occurring compound salicyluric acid methyl ester (6), and seventeen known compounds were isolated from the medicinal insect Periplaneta americana. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The absolute configurations of 2 were assigned by computational methods.

A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun.

A novel flavonoid glucoside, ruthenicunoid A (), together with eight known substances, were isolated from the fruits of Murr. Their structures were elucidated by extensive spectroscopic data and chemical methods. Especially, the absolute configuration of glucose residue in was assigned by acid hydrolysis followed by derivatization and GC analysis.

Ethyl 5-(4-amino-phen-yl)isoxazole-3-carboxyl-ate.

The asymmetric unit of the title compound, C(12)H(12)N(2)O(3), contains two mol-ecules in which the benzene and isoxazole rings are almost coplanar, the dihedral angles between their mean planes being 1.76 (9) and 5.85 (8)°.

[Effect of G protein in the dual regulation of opioid receptor agonist on the delayed rectified potassium channels].

Objective: To observe the role of G protein in the dual regulation of opioid receptor agonist on the delayed rectified potassium channels.

Methods: Using whole-cell patch-clamp techniques applied to NG108-15 cells, investigate the effect of opioid receptor agonist on the delayed rectified potassium channels by administration of Guanosine-5'-0'-2-thiociphosphate (GDP beta S), Pertusis Toxin (PTX), Tetroacetic acid nueleoside diphosphate kinase (NDPK) and Adenosine-3' 5' cyclic monophosphate cAMP in the pipette solution.

Results: (1) GDP beta S could block the changes induced by both high and low concentration of (D-Pen2.

[Dual regulation by delta opioid receptor agonists on the delayed rectified potassium channels in NG108-15 cells].

Objective: To investigate the dual effects by the delta opioid receptor agonists DPDPE on the delayed rectified potassium channels in NG108-15 cells.

Methods: A series of outward currents were evoked in NG108-15 cells by depolarizing voltage from -50 mV to +80 mV at holding potential of -90 mV. These currents were delayed rectified potassium currents.