Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment.

Background: Ferroptosis is an intracellular iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Increasing evidence indicated that ferroptosis plays a crucial role in suppressing tumors, thus providing new opportunities for cancer therapy. The drug cepharanthine, commonly used to treat leukopenia, has been discovered to function as an anticancer agent to multiple types of cancer via diverse mechanisms.

Targeted imaging of pulmonary fibrosis by a cyclic peptide LyP-1.

Pulmonary fibrosis (PF) is an interstitial chronic lung disease characterized by interstitial inflammation and extracellular matrix deposition, resulting in progressive lung dysfunction and ultimate respiratory failure. However, lacking of precise and noninvasive tracers for fibrotic lesions limits timely diagnosis and treatment. Here, we identified LyP-1, a cyclic peptide, as a specific and sensitive tracer for PF detection using PET/CT imaging.

Construction and validation of a predictive model for sleep disorders among pregnant women.

Background: Sleep disorders are among the most common major problems during pregnancy. Most studies on sleep disorders of pregnant women are closely related to adverse birth outcomes. In this study, our aim was to develop and validate a predictive model for the risk of sleep disorders in pregnant women.

[Clinical Analysis of Listeriosis in Treatment of Multiple Myeloma with Novel Agents].

Objective: To analyze the clinical characteristics and outcomes of multiple myeloma (MM) patients infected with (LM) in novel agent era, so as to improve clinicians' understanding.

Methods: Clinical data of 4 MM patients infected with LM in Beijing Chao-yang Hospital from October 2018 to October 2022 was analyzed retrospectively.

Results: The average age of the 4 patients was (57.

Dnmt3b deficiency in adipocyte progenitor cells ameliorates obesity in female mice.

Obesity arises from chronic energy imbalance where energy intake exceeds energy expenditure. Emerging evidence supports a key role of DNA methylation in the regulation of adipose tissue development and metabolism. We recently discovered a key role of DNA methylation, catalyzed by DNA methyltransferase 1 or 3a (Dnmt1 or 3a), in the regulation of adipocyte differentiation and metabolism.

User avoidance behavior in pharmaceutical e-commerce intelligent customer service: a stressor-strain-outcome perspective.

Introduction: This study explores the implementation of Intelligent Customer Service (ICS) in pharmaceutical e-commerce, aiming to enhance user acceptance and service efficiency while addressing the psychological factors influencing user behavior. It expands the boundaries of technology acceptance research by focusing on ICS use and avoidance in high-risk environments.

Method: A total of 418 valid questionnaires were collected from participants, ensuring data quality through rigorous screening.

An experimental study and prediction of dynamic deformation of wind turbine blade based on DIC.

Wind turbine blade deformation affects the ability of the blade to capture wind energy, and the dynamic deformation law of the actual wind turbine blade is unclear. This study constructs a wind turbine blade dynamic deformation measurement system based on DIC, investigates the blade dynamic deformation regularity, and fits a polynomial to predict the blade dynamic wave deformation. The results show that the modulus of elasticity of the blade determines the time required to calm the fluctuation after deformation, and the length of this time is negatively correlated with the modulus of elasticity of the blade.

Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences.

Learned action sequences are suggested to be organized hierarchically, but how the various hierarchical levels are processed by different cortical regions remains largely unknown. By training monkeys to perform heterogeneous saccade sequences, we investigated the role of the dorsolateral prefrontal cortex (DLPFC) and the lateral intraparietal cortex (LIP) in sequence planning and execution. The electrophysiological recording revealed that sequence-level initiation information was mostly signaled by DLPFC neurons, whereas subsequence-level transition was largely encoded by LIP neurons.

Characteristics and outcomes of secondary acute lymphoblastic leukemia (sALL) after multiple myeloma (MM): SEER data analysis in a single-center institution.

Background: Secondary acute lymphoblastic leukemia (sALL) is rare in patients diagnosed with antecedent multiple myeloma (MM). This study aimed to elucidate the clinical features and outcomes of patients with sALL after MM.

Methods: We conducted this population-based study using the Surveillance, Epidemiology, and End Results (SEER) database and retrospectively reviewed patients with sALL following MM treatment at our institution.

[Land use changes and driving forces of landslide area in Tongwei County, Gansu Province, Northwest China from 1985 to 2020.].

Accurately analyzing the type of land use and change characteristics of disaster damage in landslide areas is of great significance to scientifically promote the optimization of regional land use pattern and disaster prevention and mitigation. We analyzed the characteristic parameters of landslides as well as the characteristics and driving factors of land use change from 1985 to 2020 in Tongwei County, Gansu Province, using ALOS DEM data and 1985-2020 land use data, GIS spatial analysis, land-use dynamic attitude, transfer matrix, and Geodetector. The results showed that a total of 1012 landslide samples were identified, characterized by medium elevation, gentle gradient, low elevation difference, short length, and small size.

Bletilla striata polysaccharide-mediated trained immunity drives the hematopoietic progenitors' expansion and myelopoiesis.

Trained immunity represents a functional state of the innate immune response, characterized by enduring epigenetic reprogramming of innate immune cells. This phenomenon facilitates a sustained and advantageous reaction of myeloid cells to subsequent challenges. Bletilla striata polysaccharide (BSP) is the primary active component of Bletilla striata, mainly consisting of mannose and glucose in its chemical structure.

Corporate digital transformation and carbon emission intensity: Empirical evidence from listed companies in China.

Digital transformation is crucial for sustainable development of enterprises and for addressing the conundrum of "efficiency and environment". Utilizing a dataset from A-share listed companies in China from 2007 to 2021, this paper investigates the direct impact, underlying mechanism and driving effect of enterprise digital transformation on carbon emission intensity. The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing.

Effect of different internal fixation devices on intertrochanteric fractures.

Aims: To analyze the postoperative recovery effects of different internal fixations on intertrochanteric fractures, so as to select the best fixation method for clinical practice.

Methods: This is a retrospective analysis. A total of 100 patients with intertrochanteric fractures hospitalized at The Affiliated Tai'an City Central Hospital of Qingdao University from March 2022 to March 2024 were grouped according to the treatment method.

An oncoprotein CREPT functions as a co-factor in MYC-driven transformation and tumor growth.

Understanding the mechanisms behind MYC-driven oncogenic transformation could pave the way for identifying novel drug targets. This study explored the role of CREPT in MYC-induced malignancy by generating MYC-transformed mouse embryonic fibroblasts (MEFs) with conditional CREPT deletion. Our results demonstrated that the loss of CREPT significantly impaired MYC-induced colony formation and cell proliferation, indicating that CREPT is essential for the malignant transformation of MEFs.

Pesticide avermectin B1a exerts cytotoxicity by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA replication factor 1 (CDT1).

Avermectin B1a, a widely used pesticide, has recently raised safety concerns since it possesses potential cytotoxicity toward mammalian cells. Nevertheless, the exact mechanisms that underlie the cytotoxicity induced by avermectin B1a remain elusive. The loading of the mini-chromosome maintenance 6 protein (MCM6) onto chromatin at replication origins by chromatin licensing and DNA replication factor 1 (CDT1) is an essential step for licensing DNA for replication.

Evolution of Plant Genome Size and Composition.

The rapid development of sequencing technology has led to an explosion of plant genome data, opening up more opportunities for research in the field of comparative evolutionary analysis of plant genomes. In this review, we focus on changes in plant genome size and composition, examining the effects of polyploidy, whole-genome duplication, and alternations in transposable elements on plant genome architecture and evolution, respectively. In addition, to address gaps in the available information, we also collected and analyzed 234 representative plant genome data as a supplement.

Distinguishing clinical and imaging characteristics of primary central nervous system lymphoma from high-grade glioma and metastatic brain tumors.

Objective: The purpose of this retrospective analysis was to evaluate the clinical presentations, radiological characteristics, patient outcomes, and therapeutic approaches among individuals diagnosed with primary central nervous system lymphoma (PCNSL), high-grade glioma (HGG), and metastatic brain tumors (METS).

Methods: We assembled a cohort of brain tumor patients from two medical centers, with two oncologists independently reviewing their clinical profiles. A retrospective examination of 87 PCNSL, 87 HGG, and 71 METS cases was performed to assess the aforementioned parameters.

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City, China, 2010-2022.

Objective: This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome (HFRS) in Qingdao City, China.

Methods: Information was collected on HFRS cases in Qingdao City from 2010 to 2022. Descriptive epidemiologic, seasonal decomposition, spatial autocorrelation, and spatio-temporal cluster analyses were performed.

A framework supporting green stormwater management for urban designers.

Multi-objective Urban Green Space (UGS) design is essential for optimizing limited resources amid diverse urban development challenges. This study introduces a new design support tool that overcomes the data-intensive and expert-reliant limitations faced by urban designers. The tool integrates stormwater management analysis within the Rhinoceros + Grasshopper platform, offering three key features: (1) quantifying stormwater volume in the 3D model, (2) estimating the space required for stormwater management in UGS, and (3) providing options for stormwater management facilities for UGS design.

Associated factors of respiratory co-infection of COVID-19 and the impact of co-infection on SARS-CoV-2 viral load.

Introduction: Emerging evidence indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals are at an increased risk for co-infections. This retrospective study aims to expand the knowledge of associated factors of respiratory co-infection in SARS-CoV-2 positivity.

Methodology: A retrospective study was conducted to recruit fifty-five patients with laboratory-confirmed SARS-CoV-2 positivity.