Integrated transcriptomic and metabolomic analyses reveal regulatory networks governing hub metabolic pathways in Fraxinus hupehensis seeds during germination.

Efforts to protect germplasm resources of Fraxinus hupehensis (Oleaceae), an endangered species endemic to Dahong Mountain, Hubei Province, China, are facing difficulties due to the deep dormancy of its seeds. To elucidate the molecular regulatory networks underlying dormancy release, an integrated investigation combining physiological profiling with transcriptomic and metabolomic analyses was performed on seeds of F. hupehensis during six critical germination stages.

Effects of happy sensation training group on the symptom of anxiety, depression and sleep structure: a randomized controlled trial.

Background: Non-drug therapy is a common clinical treatment for chronic insomnia, and the effect of happiness perception training group based on five senses therapy on chronic insomnia has not been evaluated.

Objective: This study investigated the effects of happy sensation training group on anxiety, depression and insomnia symptoms in patients with chronic insomnia disorder.

Methods: A prospective, assessor-blind, randomized controlled design was used.

CXCL16 knockout inhibit asthma airway inflammation by suppressing H2-DM molecular mediated antigen presentation.

The inflammatory microenvironment influences dendritic cell-mediated antigen presentation to regulate asthma Th2 inflammation. The scavenger receptor is expressed on DCs and regulates antigen presentation and T priming. However, whether the transmembrane scavenger receptor (SR-PSOX/CXCL16) regulates the phenotype and antigen presentation function of DCs remains unclear.

KMT2D: A key emerging epigenetic regulator in head and neck diseases and tumors.

Histone modifications are critical determinants of chromatin accessibility and gene expression, both of which are intrinsically linked to human development and disease. Lysine methyltransferase 2D (KMT2D), a prominent member of the H3K4 methyltransferase family, is ubiquitously expressed across human tissues. Recent studies have found that it can regulate gene expression and signal pathway opening and closing in more than one way, playing an important role in cell proliferation and cell cycle homeostasis.

Exploring gender differences in workload and job performance: insights from junior high school teachers.

Background: Notable gender disparities exist in the workload and performance of junior high school teachers, although the specific ways in which these disparities manifest have not been fully elucidated. This study examines how specific aspects of teachers' workload are related to gender differences in aspects of work performance.

Methods: The study used survey data from 1135 junior high school educators.

Polylactic acid amine-sensitive colorimetric indicator film loaded with eugenol/coumarin derivatives: Towards freshness indication and shelf-life extension of chilled pork.

The action of microorganisms can lead to a decrease in food freshness and cause food safety issues. Traditional packaging can only provide a certain antimicrobial effect and cannot indicate the freshness of food, which can no longer meet the needs of consumers. The preparation of intelligent packaging films with antimicrobial effects and freshness indication is an effective solution.

Serum uric acid trajectories and risk of metabolic dysfunction-associated steatotic liver disease in China: a 2019-2021 cohort health survey.

Objective: To investigate the associations between serum uric acid (UA) trajectories and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in large cohort survey 2019-2021.

Methods: This cohort health survey included 11,644 participants without MASLD before January 1, 2021. Among them, 5578 (47.

Associations of heatwaves and their characteristics with ischaemic stroke hospital admissions.

Ischaemic stroke (IS) has a heavy disease burden. Although epidemiological research has suggested that heatwaves are associated with cardiovascular disease, there is a lack of empirical evidence for a correlation between heatwaves and IS. The China Meteorological Administration defines a heatwave as a wave lasting ≥ 3 days, with a maximum temperature of ≥ 35℃.

Integrated degradation of bacteria, organic pollutants, total phosphorus, and antibiotics in food wastewater through immobilization of Bacillus velezensis on polyethylene glycol-polyvinyl alcohol/sodium alginate/nano-TiO microspheres.

Food wastewater is characterized by complex composition and a wide range of pollutants. Existing treatment methods are often inefficient for single pollutants and new, environmentally friendly, and integrated treatment methods are needed. This study aimed to construct a novel polyethylene glycol (PEG)-polyvinyl alcohol (PVA)/sodium alginate (SA)/nano-TiO hydrogel microsphere-immobilized Bacillus velezensis system for the integrated degradation of complex pollutant components in food wastewater.

MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway.

Background: Diabetic encephalopathy (DE) is considered as one of the complications of diabetes,which is associated with cognitive impairment in the pathological process of development. Up to now, phospholipid phosphatase related 4 (Plppr4), also known as plasticity related gene 1 (PRG-1) has been revealed its important role in neuroplasticity. However, the underlying mechanisms of Plppr4 on the basis of diabetic-induced cognitive dysfunction (DCD) are still unknown.

Backbone resonance assignment of the catalytic and ATP-binding domain of CpxA from Escherichia coli.

CpxA is an extensively studied histidine kinase implicated in cellular stress responses. The highly conserved CA domain of CpxA (CpxA) is an essential domain for the hydrolysis of ATP and the binding of inhibitors and considered to be a promising target for broad-spectrum antimicrobial drugs development. The ATP-binding pocket in the CA domain contains a flexible ATP lid motif.

Exploring the role of different coping styles in mediating the relationship between dyadic adjustment status and postpartum depression among postnatal women: a single-centre, cross-sectional study.

Objectives: Postpartum depression (PPD) is a prevalent complication of childbearing, with numerous risk factors associated with its onset. Although the risk factors for PPD among postpartum women have been studied, the mechanisms underlying these factors remain inadequately understood. This study aimed to investigate the direct and mediating roles of different coping styles in the relationship between dyadic adjustment status and PPD among women 6 weeks postdelivery.

Enhancement of Oryzanol application by constructing modified β-CD inclusion complex and polycaprolactone-chitosan electrospun fiber membranes: Perspectives on wound dressings and grape preservation.

Oryzanol has a variety of physiological activities and is widely used in food and medicine. However, its utilization form and bioavailability are limited by poor solubility and photothermal stability. In this paper, an inclusion complex (IC) was prepared by modifying β-cyclodextrin as a molecular carrier to encapsulate Oryzanol.

Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China.

Neonicotinoids exposure was found to induce thyroid dysfunction. However, there lack of direct evidence between neonicotinoids exposure and thyroid hormone (TH) disruption in population study, especially in children, which limits the understanding on their health hazard. To fill this knowledge gap, we conducted a cross-sectional study on children of a rural area in South China (n = 88), and analyzed urinary ten neonicotinoids (including metabolites), serum TH, thyroxine-binding globulin (TBG), and thyroid stimulating hormone (TSH) levels.

Spatial-temporal evolution of the allometric relationship between urban economic and health resources in the Yangtze River Delta urban agglomeration.

The evolution of the spatiotemporal relationship between urban economic growth and health resources within the Yangtze River Delta urban agglomeration provides an important context for understanding the regional development dynamics in China. Previous studies focused on equity in health-resource allocation and service efficiency, often overlooking the allometric growth relationships between health resources and economic variables. This study employs an allometric growth model to elucidate the changing interactions between the number of medical beds, doctors, and urban economic indicators in the Yangtze River Delta region from 2009 to 2022.

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves' Ophthalmopathy.

Purpose: Graves' ophthalmopathy (GO), the most common extrathyroidal manifestation of Graves' disease, is disabling and disfiguring. Recent studies have shown that statins have a protective effect on individuals with GO. Statins were reported to trigger ferroptosis in some disorders, but little is known about whether statins protect against GO via ferroptosis.

An intelligent thymol/alizarin-loaded polycaprolactone/gelatin/zein nanofibrous film with pH-responsive and antibacterial properties for shrimp freshness monitoring and preservation.

Improper storage methods cause food resources to be wasted, and the development of multifunctional intelligent packaging can realize freshness monitoring and extend the shelf life. In this study, an intelligent alizarin/thymol-loaded polycaprolactone/gelatin/zein nanofibrous film was prepared and achieved the dual functions of pH-responsive and antibacterial properties. The film was fabricated using electrospun technology and characterized by SEM, FT-IR, WCA, TGA, DSC, and mechanical property tests, which had good antioxidant properties (81.

Unraveling the potential mechanism and prognostic value of pentose phosphate pathway in hepatocellular carcinoma: a comprehensive analysis integrating bulk transcriptomics and single-cell sequencing data.

Hepatocellular carcinoma (HCC) remains a malignant and life-threatening tumor with an extremely poor prognosis, posing a significant global health challenge. Despite the continuous emergence of novel therapeutic agents, patients exhibit substantial heterogeneity in their responses to anti-tumor drugs and overall prognosis. The pentose phosphate pathway (PPP) is highly activated in various tumor cells and plays a pivotal role in tumor metabolic reprogramming.

Phosphoenolpyruvate and Related Metabolic Pathways Contribute to the Regulation of Plant Growth and Development.

Phosphoenolpyruvate (PEP) plays a key role in the development of plants and exists in a wide variety of species. Research on the metabolic activities of PEP in plants has received increasing attention. PEP regulates multiple processes in plant growth and development.

Reanalysis on Performance of Microwave Phase Detector for Multisignals.

Microwave phase detectors (MPDs) are key components of instantaneous frequency measurement (IFM) receivers and phase interferometer direction finding (PIF-DF) receivers. In conventional analyses, there is seldom a major quantitative discussion of MPD characterization when multiple signals arrive at the same time, which is often the case in complex and noisy electromagnetic environments. We have reanalyzed the characteristics of MPDs with respect to filter effects acting on more than two RF signals and differential amplifiers, which are not considered in conventional analyses.

WTAP Regulates SOX1 Expression to Affect the Tumorigenicity of Colorectal Cancer via an mA-YTHDF2-Dependent Manner.

Background: Wilms tumor 1-associated protein (WTAP) plays a critical role in various cancers, including colorectal cancer (CRC). However, the biological function and molecular mechanisms of WTAP in CRC remain to be elucidated.

Methods: We determined the expression of WTAP and its correlation with unfavorable prognosis of CRC using RNA-seq and the UALCAN dataset.

Damage analysis and optimal design of micro-structure milling cutter based on peridynamics.

H13 die steel has the characteristics of high hardness, strong toughness, and good heat resistance, and is a typical difficult to process materials material. During the cutting process, it is prone to accelerate tool wear and cause thermal deformation. By reasonably designing micro-grooves, the comprehensive performance of the tool can be effectively improved.

Astaxanthin Increases Tumor Suppressor Gene Expression and Affects Cellular Biological Behavior in Oral Dysplastic Keratinocytes by Regulating DNA Methylation.

Background: The inactivation of tumor suppressor genes (TSGs) caused by abnormal DNA methylation is confirmed to be widely present in oral potential malignant diseases (OPMDs). Carotenoids like lycopene and astaxanthin can regulate DNA methylation and exert anticancer effects. Therapeutic effect of astaxanthin in OPMDs and oral squamous cell carcinoma (OSCC) models is confirmed, but the relationship between the anti-cancer ability of astaxanthin and its DNA methylation regulation ability remains unclear.