Publications by authors named "Jine Wang"

Anxiety disorder is a highly prevalent psychological illness, and research has shown that obesity is a significant risk factor for its development. This study explored the ameliorative effects and mechanisms of saponins from Panax japonicus(SPJ) on anxiety disorder in mice fed a high-fat diet(HFD). Fifty C57BL/6J mice were randomly divided into normal control diet(NCD) group, HFD group, and low-and high-dose SPJ groups.

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Background: The capsuloligamentous complex injury of the first metatarsophalangeal joint (MTPJ) is a common cause of turf toe.

Purpose: To investigate whether highresolution 3 T magnetic resonance imaging (MRI) could demonstrate all the normal anatomic structures and the MR features of the capsuloligamentous complex injury of the first MTPJ, and to evaluate the diagnostic performance of MRI in the diagnosis of the capsuloligamentous complex injuries of the first MTPJ.

Material And Methods: A total of 115 feet were included in this study, including 48 feet from 24 healthy volunteers and 67 feet from 67 patients with the capsuloligamentous complex of the first MTPJ injuries.

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Granulosa cells (GCs) are pivotal in the development of ovarian follicles, serving not only as supportive cells but also as the primary producers of steroid hormones. The proliferation of these cells and the synthesis of steroid hormones are crucial for follicular development and atresia. In our study, GCs were isolated using follicular fluid aspiration and subsequently identified through immunofluorescence.

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As a global challenge, marine biofouling is causing serious economic losses and adverse ecological impacts. In recent years, a variety of promising and environmentally friendly anti-fouling strategies have emerged, among which the excellent anti-fouling performance of bionic autocrine coatings has been recognized. However, bionic autocrine coatings still suffer from uncontrollable secretion behavior, poor mechanical stability, and poor abrasion resistance.

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Estradiol (E2) secreted by Leydig cells (LCs) can accumulate in the testes due to constriction of the reproductive lumen. Estrogen is not only important for reproduction, but also protects against inflammation. In this study, the role of pyroptosis in testicular inflammation and the effects of E2 against inflammation and pyroptosis of yak interstitial cells were investigated.

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Since most yaks have a long postpartum anestrus period, postpartum anestrus is the main factor affecting the reproductive efficiency of yaks. In this study, the third-generation sequencing technology was used to successfully screen differentially expressed genes (DEGs) and differentially expressed transcripts (DETs) in the ovarian tissues of yaks during estrus and anestrus. The functional references of DEGs and DETs were Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Clusters of Orthologous Genes database.

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Tetracyclines (TCs) rank second globally in the use of animal infection therapy and animal husbandry as growth promoters among all antibiotics. However, large amounts of TCs residue in food products and more than 75% of TCs are excreted into the environment, causing adverse effects on the ecological system and human health. It has been challenging to simultaneously realize low-cost, rapid, and highly selective detection of TCs.

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Article Synopsis
  • * A newly developed biomimetic nanoplatform can effectively deliver two drugs—retinoic acid (RA) and labetalol (LA)—to the liver, targeting the underlying mechanisms of NAFLD and improving drug release in fibrotic conditions.
  • * This innovative approach not only helps restore liver cells to a healthier state but also reduces fat accumulation, showcasing significant potential for treating NAFLD through sympathetic nerve strategies.
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Nanozymes exhibit significant potential in medical theranostics, environmental protection, energy development, and biopharmaceuticals due to their exceptional catalytic performance. Compared with natural enzymes, nanozymes have the advantages of simple preparation and purification, convenient production and low cost. Therefore, it is very important to prepare nanozymes quickly and efficiently, which not only helps to expand their application scope, but also can further exert their great potential in various fields.

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Objective: Icariin (ICA) has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging rats. Mitochondrial dysfunction is associated with brain aging-related neurodegenerative diseases. Abnormal opening of the mitochondrial permeability transition pore (mPTP) is a crucial factor in mitochondrial dysfunction and is associated with excessive autophagy.

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Article Synopsis
  • * Icariin (ICA), derived from traditional Chinese medicine, converts to Icaritin (ICT) in the body and has shown potential in protecting neurons from damage during stroke, but its exact mechanism is not fully understood.
  • * In laboratory studies, ICT was found to reduce oxidative damage and apoptosis in neuronal cells, and in animal models, it improved neurological function and decreased brain infarct volume after ischemic injury.
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Sympathetic nerves play a pivotal role in promoting tumor growth through crosstalk with tumor and stromal cells. Chemotherapy exacerbates the infiltration of sympathetic nerves into tumors, thereby providing a rationale for inhibiting sympathetic innervation to enhance chemotherapy. Here, we discovered that doxorubicin increases the density and activity of sympathetic nerves in breast cancer mainly by upregulating the expression of nerve growth factors (NGFs) in cancer cells.

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Article Synopsis
  • The brain-computer interface (BCI) enables direct interaction between the brain and external devices, playing roles in monitoring, protection, and enhancement of brain function.
  • Implantable neural electrodes provide high-quality electrophysiological data, but face challenges like tissue compatibility and performance decline over time.
  • Conductive hydrogel-based neural electrodes show promise due to their biocompatibility, minimal foreign body response, and ability to effectively transmit electrical signals for various neural applications.
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Implantable neural microelectrodes exhibit the great ability to accurately capture the electrophysiological signals from individual neurons with exceptional submillisecond precision, holding tremendous potential for advancing brain science research, as well as offering promising avenues for neurological disease therapy. Although significant advancements have been made in the channel and density of implantable neural microelectrodes, challenges persist in extending the stable recording duration of these microelectrodes. The enduring stability of implanted electrode signals is primarily influenced by the chronic immune response triggered by the slight movement of the electrode within the neural tissue.

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White adipose tissue browning can promote lipid burning to increase energy expenditure and improve adiposity. Here, we show that Slc35d3 expression is significantly lower in adipose tissues of obese mice. While adipocyte-specific Slc35d3 knockin is protected against diet-induced obesity, adipocyte-specific Slc35d3 knockout inhibits white adipose tissue browning and causes decreased energy expenditure and impaired insulin sensitivity in mice.

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Porphyrin-based metal-organic frameworks (PMOFs) are a kind of crystal hybrid material with broad application prospects in energy, catalysis, biomedicine, and other fields. In this study, the La-TCPP PMOF nanocrystal was constructed using a porphyrin ligand and La ion. This material can produce a high loading rate on doxorubicin (DOX) owing to its special porous structure.

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Marine biofouling is a thorny issue that causes serious economic losses and adverse ecological impacts on marine ecosystems. Effective and promising antifouling strategies such as surface hydration, flow shear force, and lubricant injection have been developed to address this challenge. However, for the complex marine environment, they still appear inadequate.

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Heart disease is a significant health concern for elderly individuals, with heart aging being the primary cause. Recent studies have shown that autophagy can play a protective role in preventing cardiac aging. Our previous research confirmed that Chikusetsu saponin IVa, a fundamental component of Saponins of Panax japonics (SPJ), can enhance basic autophagy levels in cardiomyocyte of isoproterenol induced cardiac fibrosis mice.

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Article Synopsis
  • Resistance to fungicides limits control over the rice fungus Magnaporthe oryzae, prompting the search for novel fungicidal agents like MoTPS1 inhibitors.
  • A new compound, j11, derived from the original hit VS-10, showed significantly greater inhibitory effects on both MoTPS1 and the fungus's pathogenicity after optimizing its structure.
  • The unique mechanism of j11 involves reducing sporulation, killing some fungal spores, and disrupting turgor pressure during infection, making it a promising candidate for effective fungicide development.
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Yak is the main livestock species in the plateau area, and its reproductive performance is low, usually two years or three years. A very few of yaks recover within a certain period of time after delivery and smoothly enter the next estrous cycle, while most of them enter the postpartum anestrus and show no estrus performance. However, the key biological factors and influencing mechanisms that cause postpartum anestrus in yaks are not clear.

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The human cardiac organoid (hCO) is three-dimensional tissue model that is similar to an organ and has great potential on heart development biology, disease modeling, drug screening and regenerative medicine. However, the construction of hCO presents a unique challenge compared with other organoids such as the lung, small intestine, pancreas, liver. Since heart disease is the dominant cause of death and the treatment of such disease is one of the most unmet medical needs worldwide, developing technologies for the construction and application of hCO is a critical task for the scientific community.

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Porphyrins are naturally occurring organic molecules that have attracted widespread attention for their potential in the field of biomedical research. Porphyrin-based metal-organic frameworks (MOFs) that utilize porphyrin molecules as organic ligands have gained attention from researchers due to their excellent results as photosensitizers in tumor photodynamic therapy (PDT). Additionally, MOFs hold significant promise and potential for other tumor therapeutic approaches due to their tunable size and pore size, excellent porosity, and ultra-high specific surface area.

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Dengue illness can range from mild illness to life-threatening haemorrhage. It is an Aedes-borne infectious disease caused by the dengue virus, which has four serotypes. Each serotype acts as an independent infectious agent.

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Article Synopsis
  • Neurons communicate through chemical and electrical signals, and monitoring both is crucial for understanding brain events and developing brain-computer interfaces (BCIs).
  • Dual-mode electrodes have been created to capture these signals simultaneously, offering valuable insights into neural networks.
  • This paper reviews advancements in neural microelectrodes, focusing on different materials like carbon, silicon, and ceramic, and discusses their designs for effective in vivo monitoring of neurochemical and electrical activity.
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Theca cells (TCs) play a unique role in the structure and function of the ovary. They are not only the structural basis of the follicle but also the androgen-secreting cells in female mammals, which can affect the normal development and atresia of the follicle. The results showed that melatonin receptor (MTR) MT1 and MT2 were expressed on sheep TCs.

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