Discovery of vitexin as a novel VDR agonist that mitigates the transition from chronic intestinal inflammation to colorectal cancer.

Colitis-associated colorectal cancer (CAC) frequently develops in patients with inflammatory bowel disease (IBD) who have been exposed to a prolonged state of chronic inflammation. The investigation of pharmacological agents and their mechanisms to prevent precancerous lesions and inhibit their progression remains a significant focus and challenge in CAC research. Previous studies have demonstrated that vitexin effectively mitigates CAC, however, its precise mechanism of action warrants further exploration.

Esculin inhibits hepatic stellate cell activation and CCl-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway.

Background: Liver fibrosis (LF) is a pathological process of the liver that threatens human health. Currently, effective treatments are still lacking. Esculin, a prominent constituent found in the Fraxinus rhynchophylla.

Evolution patterns and spatial sources of water and sediment discharge over the last 70 years in the Yellow River, China: A case study in the Ningxia Reach.

The hydrology and sediment processes in large rivers play important roles in maintaining aquatic and coastal ecosystems and advancing civilization and production in human systems. Therefore, quantitatively analyzing the spatiotemporal variability and dynamics of water and sediment discharge in large rivers is essential for improving watershed management and sustainable development in the areas surrounding rivers, especially the Yellow River, which is one of the most sediment-laden rivers in the world. In this study, we analyzed the evolution patterns and spatial sources of water and sediment discharge in the Yellow River from 1951 to 2020 and determined the impacts of different factors on water and sediment discharge variations.