Publications by authors named "Jindan Qi"
Article Synopsis
- Pancreatic cancer is extremely aggressive, with a low survival rate of 8%, primarily due to the lack of effective treatments.
- Researchers identified lycorine, a small molecule from the herb Lycoris radiata, which showed the ability to inhibit pancreatic cancer cell growth and reduce various mechanisms of cancer spread and drug resistance.
- Lycorine's effectiveness is linked to its ability to degrade the Notch1 oncoprotein and downregulate important genes related to blood vessel formation, offering a promising new approach for treating pancreatic cancer.
Article Synopsis
- KRT7-AS, a long non-coding RNA, is found to be downregulated in breast and lung cancers, indicating its potential role as a tumor suppressor, especially with low levels linking to poor prognosis in breast cancer.
- Silencing KRT7-AS in lung cancer cells led to increased oncogenic Keratin-7 levels and diminished cancer cell apoptosis, while overexpression of KRT7-AS inhibited tumor growth and sensitized cells to cisplatin, enhancing apoptosis.
- The signaling mechanism revealed that KRT7-AS interacts with the tumor suppressor PTEN, preventing its degradation, and is regulated by the transcription factor RXRα, suggesting that promoting KRT7-AS could be a therapeutic strategy against these cancers.
Background: Triple-negative breast cancer (TNBC) is highly metastatic and lethal. Due to a lack of druggable targets for this disease, there are no effective therapies in the clinic.
Methods: We used TNBC cells and xenografted mice as models to explore triptonide-mediated inhibition of TNBC metastasis and tumor growth.
Background And Aims: Insufficient dietary fiber (DF) intake is associated with increased blood pressure (BP) and the mode of action is unclear. The intake of DF supplements by participants in previous interventional studies was still far below the amount recommended by the World Health Organization. Therefore, this study aims to explore the effect of supplementing relatively sufficient DF on BP and gut microbiota in patients with essential hypertension (HTN).
View Article and Find Full Text PDFMetastatic melanoma has a very high mortality rate despite the availability of chemotherapy, radiotherapy, and immunotherapy; therefore, more effective therapeutics are needed. The Hippo pathway plays an inhibitory role in melanoma progression, but the tumor suppressors Salvador homolog-1 (SAV1) and large tumor suppressor 1 (LATS1) in this pathway are down-regulated in melanoma. As a result, the downstream oncogenic Yes-associated protein (YAP) is active, resulting in uncontrolled melanoma growth and metastasis.
View Article and Find Full Text PDFBackground: Alow carbohydrate diet (LCD) is more beneficial for the glycometabolism in type 2 diabetes (T2DM) and may be effective in reducing depression. Almond, which is a common nut, has been shown to effectively improve hyperglycemia and depression symptoms. This study aimed to determine the effect of an almond-based LCD (a-LCD) on depression and glycometabolism, as well as gut microbiota and fasting glucagon-like peptide 1 (GLP-1) in patients with T2DM.
View Article and Find Full Text PDFArticle Synopsis
- SAV1 is a crucial tumor suppressor that activates the Hippo pathway, and its deficiency is linked to increased tumor growth and poor patient prognosis in various cancers.
- Treatment with the small molecule lycorine boosts SAV1 levels in lung cancer cells by preventing its degradation and activating MST1, which in turn reduces the oncogenic YAP protein and its associated signaling pathways.
- In experiments with tumor-bearing mice, lycorine not only elevated SAV1 levels but also significantly reduced tumor growth and metastasis, suggesting a potential new therapeutic approach for lung cancer targeting SAV1 deficiency.