Turn-Off Fluorescence Sensor for the Detection of Ferric Ion in Water Using Green Synthesized Wrightia coccinea Carbon Quantum Dot.

The current study report that the production of carbon quantum dots from Wrightia coccinea (WC) leaves using an eco-friendly, one-pot process. The structural, morphological, and optical characteristics of the CDs made from W. coccinea leaves by hydrothermal treatment at 200 °C for six hours were assessed using a variety of spectroscopic and electron microscopy techniques.

Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model.

The present study has planned to evaluate the neuroprotective activity of two novel glitazones in a neuroinflammatory rat model. Two novel glitazones were selected from an in-house virtual library of glitazones based on their docking scores against peroxisome proliferator-activated receptor-gamma (PPAR-γ) protein and other parameters studied in computational studies. Initially, an acute oral toxicity study was carried out for glitazones in rats to assess the toxicity profile and to determine the therapeutic range for neuroprotective evaluation.

Minutes of PPAR-γ agonism and neuroprotection.

Peroxisome proliferator-activated receptor gamma (PPAR-γ) is one of the ligand-activated transcription factors which regulates a number of central events and considered as a promising target for various neurodegenerative disease conditions. Numerous reports implicate that PPAR-γ agonists have shown neuroprotective effects by regulating genes transcription associated with the pathogenesis of neurodegeneration. In regards, this review critically appraises the recent knowledge of PPAR-γ receptors in neuroprotection in order to hypothesize potential neuroprotective mechanism of PPAR-γ agonism in chronic neurological conditions.

Epidemiology of burn at a military hospital in Bahrain: initial experience of patient outcomes and quality indicators.

Burn injuries are one of the most common causes of morbidity and mortality in the world. We undertook a retrospective study to analyze the epidemiology and etiology of burn injuries at the burn unit of Bahrain Defence Force-Royal Medical Services from 2015 to 2016. The epidemiological and medical information were retrieved from the burn unit's (burn ward and burn intensive care unit (BICU)) medical records.

The impact of rainfall and seasonal variability on the removal of bacteria by a point-of-use drinking water treatment intervention in Chennai, India.

Point-of-use water treatment has received widespread application in the developing world to help mitigate waterborne infectious disease. This study examines the efficacy of a combined filter and chemical disinfection technology in removing bacterial contaminants, and more specifically changes in its performance resulting from seasonal weather variability. During a 12-month field trial in Chennai, India, mean log-reductions were 1.

Individual Template-Stripped Conductive Gold Pyramids for Tip-Enhanced Dielectrophoresis.

Gradient fields of optical, magnetic, or electrical origin are widely used for the manipulation of micro- and nanoscale objects. Among various device geometries to generate gradient forces, sharp metallic tips are one of the most effective. Surface roughness and asperities present on traditionally produced tips reduce trapping efficiencies and limit plasmonic applications.

Dielectrophoresis-enhanced plasmonic sensing with gold nanohole arrays.

We experimentally demonstrate dielectrophoretic concentration of biological analytes on the surface of a gold nanohole array, which concurrently acts as a nanoplasmonic sensor and gradient force generator. The combination of nanohole-enhanced dielectrophoresis, electroosmosis, and extraordinary optical transmission through the periodic gold nanohole array enables real-time label-free detection of analyte molecules in a 5 μL droplet using concentrations as low as 1 pM within a few minutes, which is more than 1000 times faster than purely diffusion-based binding. The nanohole-based optofluidic platform demonstrated here is straightforward to construct, applicable to both charged and neutral molecules, and performs a novel function that cannot be accomplished using conventional surface plasmon resonance sensors.

Ultrasmooth metallic films with buried nanostructures for backside reflection-mode plasmonic biosensing.

We present a new plasmonic device architecture based on ultrasmooth metallic surfaces with buried plasmonic nanostructures. Using template-stripping techniques, ultrathin gold films with less than 5 Å surface roughness are optically coupled to an arbitrary arrangement of buried metallic gratings, rings, and nanodots. As a prototypical example, we present linear plasmonic gratings buried under an ultrasmooth 20 nm thick gold surface for biosensing.