Publications by authors named "Jincu Qi"
Article Synopsis
- The ventricular chamber's development relies on precise interactions among different cell types, significantly influenced by alternative splicing.
- The study identifies PTBP1, an alternative splicing factor, as crucial for proper ventricular morphogenesis, particularly in endothelial cells, while being minimal in cardiomyocytes.
- Deleting PTBP1 in endothelial cells disrupts their migration, negatively impacting cardiomyocyte growth and resulting in left ventricular noncompaction (LVNC), highlighting its role in the development of congenital heart diseases.
