Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy.

T cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy. Emerging evidence has shown that interferon-gamma (IFN) could enhance CXCL9 secretion from macrophages to recruit T cells, but Siglec15 expressed on TAMs can attenuate T cell proliferation. Therefore, targeted regulation of macrophage function could be a promising strategy to enhance cancer immunotherapy concurrently promoting the infiltration and proliferation of T cells in tumor tissues.

Radiogenomics uncovers an interplay between angiogenesis and clinical outcomes in bladder cancer.

Background: Precision medicine has become a promising clinical treatment strategy for various cancers, including bladder cancer, where angiogenesis plays a critical role in cancer progression. However, the relationship between angiogenesis, immune cell infiltration, clinical outcomes, chemotherapy, and targeted therapy remains unclear.

Methods: We conducted a comprehensive evaluation of angiogenesis-related genes (ARGs) to identify their association with immune cell infiltration, transcription patterns, and clinical outcomes in bladder cancer.

Rho GTPase-activating protein 1 promotes hepatocellular carcinoma progression via modulation by CircPIP5K1A/MiR-101-3p.

Aim: There has been an increased focus on regulating cell function with Rho family GTPases, including proliferation, migration/invasion, polarity, and adhesion. Due to the challenges involved in targeting Rho family GTPases directly, it may be more effective to target their regulators, such as Rho GTPase-activating protein 1 (ARHGAP1). This present research was performed to define the clinical significance of ARHGAP1 expression, as well as its regulatory mechanisms in hepatocellular carcinoma.

Air-laser-based coherent Raman spectroscopy of atmospheric molecules in a filamentary plasma grating.

Coherent Raman spectroscopy (CRS) with air-laser-based hybrid femtosecond/picosecond (fs/ps) pulses has shown promising potential for remote detection and surveillance of atmospheric species with high temporal and frequency resolution. Here, to enhance the sensitivity and extend the detection distance, we generate the CRS spectra of air molecules in situ in a filamentary plasma grating, and show that the grating can efficiently enhance the intensities of the coherent vibrational Raman lines of N, O, and N by 2-3 orders of magnitude at an extended distance. By examining the intensities of the Raman lines, fs-pulsed supercontinuum, and ps-pulsed air laser produced under different grating conditions, we reveal that the optimization of the Raman lines is achieved by the dynamic balance between the supercontinuum-induced vibrational coherence and air-laser-induced polarization of the air species.

Transition from triggered super-radiance to seed amplification in N lasing.

Air lasing induced by laser filamentation opens a new route for research on atmospheric molecular physics and remote sensing. The generation of air lasing is composed of two processes, i.e.

Experimental and Numerical Evaluation on the Performance of Perfobond Leiste Shear Connectors in Steel-SFRCC Composite Beams.

The difference between the shear performances of Perfobond Leiste (PBL) shear connectors embedded in steel fiber-reinforced cementitious composite (SFRCC) structure and normal strength concrete (NC) structure was investigated by push-out tests and finite element (FE) simulations. Push-out tests were carried out on nine steel-SFRCC specimens and nine steel-NC specimens. The mechanical behavior of the PBL shear connector was examined according to the failure modes, load-slip curves, and strain distribution laws of the push-out specimens.

Innovative signature establishment using lymphangiogenesis-related lncRNA pairs to predict prognosis of hepatocellular carcinoma.

Aims: Hepatocellular carcinoma (HCC) remains a major tumoral burden globally, and its heterogeneity encumbers prognostic prediction. The lymphangiogenesis-related long non-coding RNAs (lrlncRNAs) reported to be implicated in immune response regulation show potential importance in predicting the prognostic and therapeutic outcome. Hence, this study aims to establish a lrlncRNA pairs-based signature not requiring specific expression levels of transcripts, which displays promising clinical practicality and satisfactory predictive capability.

Extremely enhanced N lasing in a filamentary plasma grating in ambient air.

Cavity-free air lasing offers a promising route towards the realization of atmospheric lasers for various applications such as remote sensing and standoff spectroscopy; however, achieving efficient generation and control of air lasing in ambient air is still a challenge. Here we show the experimental realization of a giant lasing enhancement by three to four orders of magnitude in ambient air for the self-seeded 2+ lasing at 428 nm, assigned to the +(=0) and +(=1) emission, by modulating the spatiotemporal overlap of ultrashort near-infrared control-pump pulses in a filamentary plasma grating; meanwhile, the spontaneous emission from the same transition is only enhanced by three to four times. We find that this enhancement is sensitive to the relative polarization and interference time of the two pulses, and reveal that the formation of the plasma grating induces different population variations in the +(=0) and +(=1) levels, resulting in an enormous population inversion between the two levels, thereby a higher gain for the giant enhancement of 2+ lasing in ambient air.

Effects of prolonged photoperiod on growth performance, serum lipids and meat quality of Jinjiang cattle in winter.

Objective: This study was conducted to investigate the potential effects of prolonged photoperiod on the serum lipids, carcass traits, and meat quality of Jinjiang cattle during winter.

Methods: Thirty-four Jinjiang bulls aged between 14 and 16 months were randomly assigned to two groups that were alternatively subjected to either natural daylight +4 h supplemental light (long photoperiod, LP) or natural daylight (natural photoperiod, NP) for 96 days. The potential effects on the levels of serum lipids, carcass traits, meat quality, and genes regulating lipid metabolism in the intramuscular fat (IMF) of the cattle were evaluated.

FeO@Carbon Nanofibers Synthesized from Cellulose Acetate and Application in Lithium-Ion Battery.

FeO@CNF anode material for Li-ion batteries (LIBs) was designed and fabricated using lyotropic cellulose acetate as the carbon nanofiber (CNF) phase and Fe(acac) as the FeO phase through the electrospinning approach. Because the CNFs could retard the change of FeO volume during the electrochemical cycling and improve the electrical conductivity and the introduction of FeO could offer a larger specific surface area and more mesopores to promote electrolyte penetration and Li diffusion, the FeO@CNFs electrode showed high reversible capacities (RCs) of 773.6 and 596.