An Improved Unscented Kalman Filter Applied to Positioning and Navigation of Autonomous Underwater Vehicles.

To enhance the positioning accuracy of autonomous underwater vehicles (AUVs), a new adaptive filtering algorithm (RHAUKF) is proposed. The most widely used filtering algorithm is the traditional Unscented Kalman Filter or the Adaptive Robust UKF (ARUKF). Excessive noise interference may cause a decrease in filtering accuracy and is highly likely to result in divergence by means of the traditional Unscented Kalman Filter, resulting in an increase in uncertainty factors during submersible mission execution.

Protecting Against Postsurgery Oral Cancer Recurrence with an Implantable Hydrogel Vaccine for In Situ Photoimmunotherapy.

Oral squamous cell carcinoma (OSCC) often recurs aggressively and metastasizes despite surgery and adjuvant therapy, driven by postoperative residual cancer cells near the primary tumor site. An implantable in situ vaccine hydrogel was designed to target residual OSCC cells post-tumor removal. This hydrogel serves as a reservoir for the sustained localized release of δ-aminolevulinic acid (δ-ALA), enhancing protoporphyrin IX-mediated photodynamic therapy (PDT), and a polydopamine-hyaluronic acid composite for photothermal therapy (PTT).

Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma.

Radiofrequency ablation (RFA) is a commonly used minimally invasive treatment for hepatocellular carcinoma (HCC). However, incomplete radiofrequency ablation (iRFA) promotes tumor progression and metastasis. There is an urgent need to develop innovative strategies to enhance the efficacy of iRFA.

Tumor microenvironment-modulated nanoparticles with cascade energy transfer as internal light sources for photodynamic therapy of deep-seated tumors.

Photodynamic therapy (PDT) is an appealing modality for cancer treatments. However, the limited tissue penetration depth of external-excitation light makes PDT impossible in treating deep-seated tumors. Meanwhile, tumor hypoxia and intracellular reductive microenvironment restrain the generation of reactive oxygen species (ROS).

Transcriptome analysis and functional verification reveal the roles of copper in resistance to potato virus Y infection in tobacco.

Potato virus Y (PVY) is one of the most important pathogens in the genus Potyvirus that seriously harms agricultural production. Copper (Cu), as a micronutrient, is closely related to plant immune response. In this study, we found that foliar application of Cu could inhibit PVY infection to some extent, especially at 7 days post inoculation (dpi).

Attributable mortality of acute kidney injury among critically ill patients with sepsis: a multicenter, retrospective cohort study.

Background: Sepsis and acute kidney injury (AKI) are common severe diseases in the intensive care unit (ICU). This study aimed to estimate the attributable mortality of AKI among critically ill patients with sepsis and to assess whether AKI was an independent risk factor for 30-day mortality.

Methods: The information we used was derived from a multicenter prospective cohort study conducted in 18 Chinese ICUs, focusing on septic patients post ICU admission.

Sorafenib-Encapsulated Liposomes to Activate Hypoxia-Sensitive Tirapazamine for Synergistic Chemotherapy of Hepatocellular Carcinoma.

Combination therapy with the synergistic effect is an effective way in cancer chemotherapy. Herein, an antiangiogenic sorafenib (SOR) and hypoxia-activated prodrug tirapazamine (TPZ)-coencapsulated liposome (Lip) is prepared for chemotherapy of hepatocellular carcinoma (HCC). SOR is a multi-target tyrosine kinase inhibitor that can inhibit tumor cell proliferation and angiogenesis.

1/4 is the new 1/2 when topology is intertwined with Mottness.

In non-interacting systems, bands from non-trivial topology emerge strictly at half-filling and exhibit either the quantum anomalous Hall or spin Hall effects. Here we show using determinantal quantum Monte Carlo and an exactly solvable strongly interacting model that these topological states now shift to quarter filling. A topological Mott insulator is the underlying cause.

Failure of Topological Invariants in Strongly Correlated Matter.

We show exactly that standard "invariants" advocated to define topology for noninteracting systems deviate strongly from the Hall conductance whenever the excitation spectrum contains zeros of the single-particle Green's function, G, as in general strongly correlated systems. Namely, we show that if the chemical potential sits atop the valence band, the "invariant" changes without even accessing the conduction band but by simply traversing the band of zeros that might lie between the two bands. Since such a process does not change the many-body ground state, the Hall conductance remains fixed.

Regulating AlO/PAN/PEG Nanofiber Membranes with Suitable Phase Change Thermoregulation Features.

To address the thermal comfort needs of the human body, the development of personal thermal management textile is critical. Phase change materials (PCMs) have a wide range of applications in thermal management due to their large thermal storage capacity and their isothermal properties during phase change. However, their inherent low thermal conductivity and susceptibility to leakage severely limit their application range.

Fluorine-Free, Highly Durable Waterproof and Breathable Fibrous Membrane with Self-Clean Performance.

Lightweight, durable waterproof and breathable membranes with multifunctional properties that mimic nature have great potential for application in high-performance textiles, efficient filtering systems and flexible electronic devices. In this work, the fluoride-free triblock copolymer poly(styrene-b-butadiene-b-styrene) (SBS) fibrous membrane with excellent elastic performance was prepared using electrospinning. According to the bionics of lotus leaves, a coarse structure was built onto the surface of the SBS fiber using dip-coating of silicon dioxide nanoparticles (SiO NPs).

A Fast Decision Algorithm for VVC Intra-Coding Based on Texture Feature and Machine Learning.

Due to the development and application of information technology, a series of modern information technologies represented by 5G, big data, and artificial intelligence are changing rapidly, and people's requirements for video coding standards have become higher. In the High-Efficiency Video Coding (HEVC) standard, the coding block division is not flexible enough, and the prediction mode is not detailed enough. A new generation of Versatile Video Coding (VVC) standards was born.

Recombinant HNP-1 Produced by Escherichia coli Triggers Bacterial Apoptosis and Exhibits Antibacterial Activity against Drug-Resistant Bacteria.

Human neutrophil peptide-1 (HNP-1) is a promising antibiotic candidate, but its clinical applications have been hampered by challenges during mass production and an inadequate understanding of its bactericidal mechanisms. In this study, we demonstrated that Escherichia coli expressing full-length preproHNP-1 secretes a soluble form of HNP-1, which can be recovered from the total cell lysate after isopropyl thio-β-d-galactoside (IPTG) induction and ultrafiltration. Label-free quantitative proteomics and co-immunoprecipitation experiments revealed that HNP-1 induces cell apoptosis in bacteria by causing DNA and membrane damage.

E/D-Mode GaN Inverter on a 150-mm Si Wafer Based on p-GaN Gate E-Mode HEMT Technology.

AlGaN/GaN E/D-mode GaN inverters are successfully fabricated on a 150-mm Si wafer. P-GaN gate technology is applied to be compatible with the commercial E-mode GaN power device technology platform and a systematic study of E/D-mode GaN inverters has been conducted with detail. The key electrical characters have been analyzed from room temperature (RT) to 200 °C.

The dynamic transmission of positional information in mutants during embryogenesis.

It has been suggested that Staufen (Stau) is key in controlling the variability of the posterior boundary of the Hb anterior domain (). However, the mechanism that underlies this control is elusive. Here, we quantified the dynamic 3D expression of segmentation genes in embryos.

Shape Tuning and Size Prediction of Millimeter-Scale Calcium-Alginate Capsules with Aqueous Core.

Controllable feature and size, good mechanical stability and intelligent release behavior is the capsule products relentless pursuit of the goal. In addition, to illustrate the quantitative relationship of structure and performance is also important for encapsulation technology development. In this study, the sphericity and size of millimeter-scale calcium sodium alginate capsules (mm-CaSA-Caps) with aqueous core were well tuned by manipulating the viscosity, surface tension, and density of CaCl/carboxyl methyl cellulose (CMC) drops and sodium alginate (SA) solution.

Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway.

Current studies have shown that circular RNAs (circRNAs) and microRNAs (miRNAs) are closely related in acute myocardial infarction (AMI). Previous studies have shown that miR-125b promotes fibrosis and up-regulates in cardiac fibroblasts (CFs), and further experiments showed that circ_LAS1L had multiple binding sites of miR-125b, and their expression was inversely related in AMI patients and CFs. RNA immunoprecipitation (RIP), pull down, and dual luciferase reporter gene assay all confirmed that miR-125b directly bound to circ_LAS1L.

Bio-based barium alginate film: Preparation, flame retardancy and thermal degradation behavior.

A bio-based barium alginate film was prepared via a facile ionic exchange and casting approach. Its flammability, thermal degradation and pyrolysis behaviors, thermal degradation mechanism were studied systemically by limiting oxygen index (LOI), vertical burning (UL-94), microscale combustion calorimetry (MCC), thermogravimetric analysis (TGA) coupled with Fourier transform infrared analysis (FTIR) and pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS). It showed that barium alginate film had much higher LOI value (52.

Additive anticancer effects of chrysin and low dose cisplatin in human malignant glioma cell (U87) proliferation and evaluation of the mechanistic pathway.

Purpose: To evaluate the anticancer effect of chrysin and its additive combination with low-dose cisplatin in human glioma (U87) cancer cells and to study its underlying mechanism.

Methods: Inverted phase and fluorescence microscopic studies were done to demonstrate the effect of chrysin and its combination with cisplatin on cellular morphology and apoptosis. Annexin V-FITC assay was used to quantify the extent of apoptosis in chrysin and chrysin+cisplatin treated cells.

Fabrication of interpenetrating polymer network chitosan/gelatin porous materials and study on dye adsorption properties.

One kind of adsorbent based on chitosan and gelatin with interpenetrating polymer networks (IPN) and porous dual structures was prepared using genipin as the cross-linker. These dual structures were demonstrated by means of Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). Adsorptions of acid orange II dye from aqueous solution were carried out at different genipin contents, adsorption times and pH values.

[Construction of an acellular porcine aortic valve].

Objective: To prepare a porcine aortic valve (PAV) free of the cellular components.

Methods: The cellular components of porcine PAV were completely removed using trypsin and Triton X-100, and the acellular PAV was examined microscopically with HE staining with its physical and chemical properties assessed. Transmission electron microscopy was used to observe the integrity of the collagen and elastin and the DNA contents in the PAV was detected to confirm the total removal of the cellular components.