Publications by authors named "Jinbo Xu"

Article Synopsis
  • Developmental delay (DD) and intellectual disability (ID) are common neurodevelopmental disorders with complex genetic backgrounds, making diagnosis challenging; whole exome sequencing (WES) serves as an effective tool for identifying genetic causes in these patients.* -
  • A study analyzed WES data from 280 patients with unexplained DD/ID, finding pathogenic genetic variants in 36.07% of cases, and noted that while various clinical factors did not notably affect the outcomes, delivery mode showed a significant correlation to positive WES results.* -
  • The use of WES is beneficial for determining genetic causes of unexplained DD/ID, aiding in patient management, family counseling, and assessing long-term prognoses.*
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Carbon capture, utilization, and storage (CCUS) is an important component in many national net-zero strategies, and ensuring that CO can be safely and economically stored in geological systems is critical. Recent discoveries have shown that microbial processes (e.g.

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Traditional image classification usually relies on manual feature extraction; however, with the rapid development of artificial intelligence and intelligent vision technology, deep learning models such as CNNs can automatically extract key features from input images to achieve efficient classification. This study focuses on the application of lightweight separable convolutional neural networks in domain-specific image classification tasks. In this paper, we discuss how to use the SSDLite object detection algorithm combined with the MobileNetV2 lightweight convolutional architecture for puppet dynasty recognition from images-a novel and challenging task.

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Oil reservoirs, being one of the significant subsurface repositories of energy and carbon, host diverse microbial communities affecting energy production and carbon emissions. Viruses play crucial roles in the ecology of microbiomes, however, their distribution and ecological significance in oil reservoirs remain undetermined. Here, we assemble a catalogue encompassing viral and prokaryotic genomes sourced from oil reservoirs.

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Background: The Oka varicella vaccine strain remains neurovirulent and can establish lifelong latent infection, raising safety concerns about vaccine-related herpes zoster. In this study, we aimed to evaluate the immunogenicity and safety of a skin-attenuated and neuro-attenuated varicella vaccine candidate (v7D vaccine).

Methods: We did this randomised, double-blind, controlled, phase 2a clinical trial in Jiangsu, China.

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Protein structure prediction has been greatly improved by deep learning in the past few years. However, the most successful methods rely on multiple sequence alignment (MSA) of the sequence homologs of the protein under prediction. In nature, a protein folds in the absence of its sequence homologs and thus, a MSA-free structure prediction method is desired.

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With the development of artificial intelligence, neural network provides unique opportunities for holography, such as high fidelity and dynamic calculation. How to obtain real 3D scene and generate high fidelity hologram in real time is an urgent problem. Here, we propose a liquid lens based holographic camera for real 3D scene hologram acquisition using an end-to-end physical model-driven network (EEPMD-Net).

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Accurate prediction of antibody-antigen complex structures is pivotal in drug discovery, vaccine design and disease treatment and can facilitate the development of more effective therapies and diagnostics. In this work, we first review the antibody-antigen docking (ABAG-docking) datasets. Then, we present the creation and characterization of a comprehensive benchmark dataset of antibody-antigen complexes.

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In this paper, a dual interface trapezium liquid prism with beam steering function is implemented and analyzed. The electrowetting-on-dielectric method is used to perform the desired beam steering function without mechanical moving parts. This work examines deflection angles at different applied voltages to determine the beam steering range.

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Article Synopsis
  • - The study investigates microbial communities in petroleum reservoirs under high-pressure conditions, focusing on methanogenic and sulfate-reducing environments using production water from the Jilin Oilfield in China.
  • - A 90-day incubation revealed key microbial groups, with methanogenic conditions dominated by Firmicutes and unique methanogens, while sulfate-reducing communities were mostly Firmicutes and other candidate taxa important for nutrient exchange.
  • - The research highlights the importance of microbial interactions and metabolic roles in petroleum degradation, suggesting that high-pressure conditions can uncover previously overlooked microbial functions, often referred to as "microbial dark matter."
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Inspired by the arrangement of iris and crystalline lens in human eyes, we propose a three-phase electrowetting liquid lens with a deformable liquid iris (TELL-DLI). The proposed electrowetting liquid lens has three-phase fluid: air, conductive liquid, and dyed insulating liquid. The insulating liquid is distributed on the inner wall of the chamber in a ring shape.

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Neonatal hypoxic-ischemic brain damage (HIBD) is a leading cause of infant mortality worldwide. This study explored whether quercetin (Que) exerts neuroprotective effects in a rat model of HIBD. A total of 36 seven-day-old Sprague-Dawley rats were divided into control, Que, HI, and HI + Que groups.

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Background: The real-world data of long-term protection under moderate vaccination coverage is limited. This study aimed to evaluate varicella epidemiology and the long-term effectiveness under moderate coverage levels in Ganyu District, Lianyungang City, Jiangsu Province.

Methods: This was a population-based, retrospective birth cohort study based on the immunization information system (IIS) and the National Notifiable Disease Surveillance System (NNDSS) in Ganyu District.

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Geometric deep learning has recently achieved great success in non-Euclidean domains, and learning on 3D structures of large biomolecules is emerging as a distinct research area. However, its efficacy is largely constrained due to the limited quantity of structural data. Meanwhile, protein language models trained on substantial 1D sequences have shown burgeoning capabilities with scale in a broad range of applications.

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Article Synopsis
  • A study compared the immunogenicity of a new HPV vaccine, Cecolin 9, produced by E. coli, with the established Gardasil 9, focusing on various HPV types including 6, 11, 16, 18, and others.
  • Conducted in China, the randomized trial included 487 healthy women aged 18-26, who received three doses of either vaccine, and measured antibody responses to determine effectiveness.
  • Results showed both vaccines achieved a 100% seroconversion rate, with Cecolin 9 demonstrating comparable or superior antibody levels for several HPV types, suggesting it may be an effective alternative to Gardasil 9.
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AlphaFold-Multimer has greatly improved the protein complex structure prediction, but its accuracy also depends on the quality of the multiple sequence alignment (MSA) formed by the interacting homologs (i.e. interologs) of the complex under prediction.

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Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole-genome sequencing data for 809 individuals from 233 primate species and identified 4.3 million common protein-altering variants with orthologs in humans.

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Protein side-chain packing (PSCP), the task of determining amino acid side-chain conformations given only backbone atom positions, has important applications to protein structure prediction, refinement, and design. Many methods have been proposed to tackle this problem, but their speed or accuracy is still unsatisfactory. To address this, we present AttnPacker, a deep learning (DL) method for directly predicting protein side-chain coordinates.

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Unlabelled: Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained whole genome sequencing data for 809 individuals from 233 primate species, and identified 4.3 million common protein-altering variants with orthologs in human.

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A chemical investigation of the EtOAc extract of the endophytic fungus Penicillium herquei led to the isolation of nine undescribed oxidized ergosterols, penicisterols A-I (1-9), along with ten known analogs (10-19). Their structures and absolute configurations were elucidated by a combination of spectroscopic data analysis, quantum-chemical electronic circular dichroism (ECD) calculations and comparisons, [Rh(OCOCF)]-induced ECD experiments, DFT-calculated C chemical shifts and DP4+ probability analysis. Compound 1 was a rare example of ergosterol in which the bond between C-8 and C-9 was cleaved to form an enol ether.

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Objective: To observe the clinical efficacy of scalp acupuncture for spastic cerebral palsy (CP), and to explore its possible mechanism based on brain white matter fiber bundles, nerve growth related proteins and inflammatory cytokines.

Methods: A total of 90 children with spastic CP were randomly divided into a scalp acupuncture group and a sham scalp acupuncture group, 45 cases in each group. The children in the two groups were treated with conventional comprehensive rehabilitation treatment.

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In recent years, the continuous development of electronic chips and the increasing integration of devices have led to extensive research on the thermal properties of ultrathin metallic materials. In particular, accurate characterization of their thermal transport properties has become a research hotspot. In this paper, we review the characterization methods of metallic nanomaterials, focusing on the principles of the transient electrothermal (TET) technique and the differential TET technique.

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To investigate the leaching characteristics and potential environmental effects of potentially toxic metals (PTMs) from alum mine tailings in Lujiang, Anhui Province, soaking tests and simulated rainfall leaching experiments were conducted for two types of slag. PTMs comprising Cd, Cr, Cu, Mn, and Ni were detected in the slag. Cu and Cd contents exceeded the national soil risk screening values (GB 15618-2018).

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Background: The ulcerative colitis (UC) and Crohn's disease (CD) subtypes of inflammatory bowel disease (IBD) are autoimmune diseases influenced by multiple complex factors. The clinical treatment strategies for UC and CD often differ, indicating the importance of improving their discrimination.

Methods: Two methods, robust rank aggregation (RRA) analysis and merging and intersection, were applied to integrate data from multiple IBD cohorts, and the identified differentially expressed genes (DEGs) were used to establish a protein-protein interaction (PPI) network.

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Motivation: Protein structure prediction has been greatly improved by deep learning, but the contribution of different information is yet to be fully understood. This article studies the impacts of two kinds of information for structure prediction: template and multiple sequence alignment (MSA) embedding. Templates have been used by some methods before, such as AlphaFold2, RoseTTAFold and RaptorX.

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