Circular RNAs in atrial fibrillation: From bioinformatics analysis of circRNA-miRNA-mRNA network to serum expression.

Atrial fibrillation (AF) is a common arrhythmia in clinical practice, and its incidence is increasing year by year, which seriously affects the survival and prognosis of patients. In recent years, circRNAs has played an important role in the diagnosis and treatment of AF. The purpose of this study was to search for differentially expressed circRNAs(DEcircRNAs) in the serum of AF patients by analyzing the expression profile of existing chips, combining bioinformatics technology and in vitro experiments, and to explore the regulatory mechanism of circRNAs in the occurrence and development of AF.

Research progress of non-coding RNA in atrial fibrillation.

Atrial fibrillation (AF) is a common arrhythmia in clinic, and its incidence is increasing year by year. In today's increasingly prevalent society, ageing poses a huge challenge to global healthcare systems. AF not only affects patients' quality of life, but also causes thrombosis, heart failure and other complications in severe cases.

Study on Impermeability of Foamed Concrete Containing Municipal Solid Waste Incineration Powder.

In this paper, the effects of dry density, w/c ratio, and municipal solid waste incineration (MSWI) powder on the multi-scale properties and internal pore structure of foamed concrete were studied by using a single-factor controlled experiment. It was found that an increase in the dry density of foamed concrete could effectively reduce the porosity, leading to the improvement of compressive strength and impermeability and to the reduction of water absorption. The compressive strength, water absorption, and impermeability were mainly affected by the porosity when the w/c ratio changed.

Synthesis and optical properties of Schiff base derivatives based on 2-(2-hydroxyphenyl)benzothiazole (HBT) and application in the detection of NH.

Four 2-(2-hydroxyphenyl)benzothiazole-based Schiff base derivatives incorporating different substituents were synthesized. Their optical properties were characterized by UV-visible and fluorescence spectra. The electron-withdrawing and electron-donating actions of substituents can change the orbital energy level distributions of molecules resulting in the difference of their luminescence properties.

A reusable test paper based on a simple salicylaldehyde derivate for the real-time detection of phosgene in gas phase.

Phosgene is an important organic activity intermediate as well as a poisonous gas. However, the widespread use and abuse of phosphene brings potential risks to public safety. So it is very important to detect phosgene quickly and reliably.

A ratiometric fluorescent probe for the rapid and specific detection of HSO in water samples.

Hydrosulphite (HSO ), as a common and important chemical reagent, is widely used in everyday life, however excessive use and abuse of HSO can cause potential harmful effects on the environment and in biological health. In this paper, we describe the design and preparation of a colorimetric and ratiometric fluorescence probe for the visual detection of HSO (excitation wavelengths were, respectively, 336 nm and 520 nm). This method showed some advantages including simple preparation, high selectivity, fast response, and significant colour and fluorescence ratio (F /F ) changes in the presence of HSO .

A metal-free coumarin-based fluorescent probe for the turn-on monitoring of carbon monoxide in an aqueous solution and living cells.

Endogenous carbon monoxide (CO) is an essential cell signaling molecule, which is closely related to numerous physiological and pathological processes. Therefore, it is of great significance to monitor CO in living samples. Fluorescent probe technique provides an effective and convenient method for monitoring CO.

Recent Progress in the Development of Fluorescent Probes for the Detection of Hydrazine (NH).

ABSTACTWith the widespread use of NH, it brings potential risk to human health and environmental safety because of its diverse toxicological functions. In order to determine NH effectively in both environment and living systems, all kinds of fluorescence probes have been prepared for the specific response of NH based on various mechanisms and different acceptor group for NH. This paper provides a review to bring more inspirations for the development of the fluorescent probes for NH.

Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats.

There is a special role for estrogens in preventing and curing cardiovascular disease in women. Soy isoflavone (SI), a soy-derived phytoestrogen, has similar chemical structure to endogenous estrogen-estradiol. We investigate to elucidate the protective mechanism of SI on myocardial ischemia/reperfusion (MI/R) injury.

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis.

Hydrogen sulfide (H2S) is a gasotransmitter which regulates multiple cardiovascular functions. However, the precise roles of H2S in modulating myocardial fibrosis in vivo and cardiac fibroblast proliferation in vitro remain unclear. We investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial fibrosis.

Droplet-in-oil array for picoliter-scale analysis based on sequential inkjet printing.

In recent years, inkjet printing, as a new method to fabricate microdroplet microarrays, has been increasingly applied in the field of biochemical diagnostics. To further improve the general applicability of the inkjet printing technology in fabricating biochemical chips, in this work, we introduce a model to describe the multiple injection procedure implemented by the inkjet printing approach, with experimental verification. The multiple injection model demonstrates a new sequential inkjet printing method that generates picoliter-scale multicomponent droplet-in-oil arrays via multistep printing on uniform planar substrates.