The Infection Properties of Hemorrhagic Syndrome Virus and the Antiviral Effect of Curcumin In Vivo.

hemorrhagic syndrome virus (TSHSV) is an aquatic arterivirus causing a high mortality rate for (Chinese soft-shelled turtle), but the detailed infection properties of TSHSV are unclear, and no effective treatment is available. In this study, cell culture and histopathology were performed to elucidate the infection properties of TSHSV. Furthermore, the anti-TSHSV and immune-enhancing effects of curcumin were evaluated using survival statistics, qPCR, and tissue immunofluorescence.

Complete Mitochondrial Genomes of Four Strains and Comparison with Other Trionychidae Species.

The Chinese soft-shelled turtle () is an important aquaculture reptile with rich nutritional and medicinal values. In recent decades, the wild resources of have been depleting due to natural and artificial factors. Herein, we report the complete mitochondrial genome of four strains, including the Japanese (RB) strain, Qingxi Huabie (HB) strain, Jiangxi (JB) strain, and Qingxi Wubie (WB) strain.

Synthesis and Azobenzene Isomerization Investigation of Photoswitchable Glycomacrocycles.

Macrocyclic glycoazobenzenes, as an emerging class of photoswitchable chiral macrocyclic compounds, have shown interesting properties since their discovery in 2017. We have recently employed the azobenzene-ester-linked glycosyl donor-acceptor pairs to study the influence of photoisomerization on intramolecular glycosylation. To continue the investigation on the stereoselectivity aspect of glycosylation and also to enlarge the diversity of photoswitchable glycomacrocycles, we have chosen azobenzene-triazole linkers in the present study and shown that the stereoselectivity of the glycosylation is dependent on the linker length, the configuration of the azobenzene template, as well as the reaction concentration.

Stereoselective synthesis and properties of glycoazobenzene macrocycles through intramolecular glycosylation.

An intramolecular glycosylation strategy was used to synthesize a series of new glycoazobenzene macrocycles with high α-selectivity and interesting chiroptical properties. The photoisomerization of an azobenzene template influences mainly the efficiency of the glycosylation.

Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy.

As a result of their high specificity for their corresponding biological targets, peptides have shown significant potential in a range of diagnostic and therapeutic applications. However, their widespread use has been limited by their minimal cell permeability and stability in biological milieus. We describe here a hepta-dicyanomethylene-4-pyran appended β-cyclodextrin () that acts as a delivery enhancing "host" for 1-bromonaphthalene-modified peptides, as demonstrated with peptide probes .

An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.

A series of 3-hydroxyflavone (3-HF) ESIPT (excited-state intramolecular proton transfer) boronate-based fluorescent probes have been developed for the detection of peroxynitrite (ONOO). The dyes are environmentally sensitive, and each probe exhibited a ratiometric response toward ONOO in a micellar environment. The probes were used to image different aggregation states of amyloid-β (Aβ) in the presence of ONOO.

Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking.

Here we show that graphene oxide greatly enhances the imaging ability of a peptide probe that selectively targets microtubules of the cytoskeleton, thus enabling the dynamic tracking of mitosis in live cells.