Publications by authors named "Jinbao Li"
Lithium-sulfur batteries (LSBs) continue to encounter significant challenges in practical applications, primarily attributed to the low electrical conductivity of the cathode active material sulfur, volume expansion during cycling and the uncontrolled shuttle effect of lithium polysulfides (LiPSs). In this work, flexible meta-aramid fibrids (AFs) were innovatively introduced, and polydopamine (PDA) was employed to effectively adhere highly conductive multiwalled carbon nanotubes (MWCNTs) to the AFs surface, thereby forming nanoscale conductive pathways. A wet-laid process analogous to aramid paper-making was utilized to enhance interfacial bonding between AFs and rigid carbon fibers (CFs), resulting in a self-supporting paper-based cathode material with a uniform, dense three-dimensional micronano-scale conductive network and stable structure.
View Article and Find Full Text PDFOsteonecrosis of the femoral head (ONFH) remains a significant clinical challenge. Despite various strategies aimed at promoting bone repair and halting disease progression, an effective cure remains elusive. Recent studies have identified a non-bone-resorbing osteoclast subtype, vessel-associated osteoclasts (VAOs), distinct from classical bone-associated osteoclasts (BAOs), offering new therapeutic opportunities for ONFH.
View Article and Find Full Text PDFCruciferous crops are essential components of global agricultural production due to their rich nutritional value and extensive economic benefits. Black rot caused by Xanthomonas campestris pv. campestris (Xcc) has caused significant losses to cruciferous crops.
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- Delayed healing in diabetic wounds is primarily due to a dysfunctional microenvironment caused by high blood sugar and ongoing inflammation.
- Topical microenvironment modulation, particularly using microneedles, offers a promising solution to enhance healing by delivering therapeutic agents directly to the wound's surface.
- A hybrid microneedle has been developed incorporating carvacrol, cyclodextrin, mesoporous ceria nanoparticles, and hyaluronate, which improves healing by providing antibacterial, antioxidant, and anti-inflammatory effects to accelerate tissue reconstruction processes like cell proliferation and angiogenesis.
Achieving high shielding effectiveness in electromagnetic shielding materials relies heavily on high conductivity, yet simultaneously enhancing the absorption loss remains a persistent challenge. Consequently, the study successfully creates efficient electromagnetic shielding composite films with a unique grape-like bunch structure of hollow nanosilver (HCAF) through layer-by-layer assembly. The utilization of poly(dopamine) (PDA) to anchor nanosilver granules (AgNPs) onto cellulose nanofibers (CNF) results in the formation of CNF@PDA@AgNPs.
View Article and Find Full Text PDFTypes of cell death in diabetic cardiomyopathy: insights from animal models.
Acta Biochim Biophys Sin (Shanghai)
December 2024
Approximately one-tenth of the global population is affected by diabetes mellitus, and its incidence continues to rise each year. In China, 1.4 million patients die from diabetes-related complications every year.
View Article and Find Full Text PDFMedical image segmentation is essential for accurately representing tissues and organs in scans, improving diagnosis, guiding treatment, enabling quantitative analysis, and advancing AI-assisted healthcare. Organs and lesion areas in medical images have complex geometries and spatial relationships. Due to variations in the size and location of lesion areas, automatic segmentation faces significant challenges.
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- Sepsis is a serious condition involving multiple organ failure due to an irregular immune response, with miR-31 being a potentially important but under-researched molecule in this context.
- The study assessed the levels of miR-31-5p in sepsis patients and used an experimental model to explore its effects on survival, organ injury, and inflammation, revealing that higher levels in non-survivors correlate with worse outcomes.
- miR-31-5p was found to inhibit beneficial M2 macrophage polarization, and treatment with miPEP31 significantly improved survival rates and reduced organ damage in sepsis, emphasizing its therapeutic potential.
REGγ deficiency ameliorates hepatic ischemia and reperfusion injury in a mitochondrial p66shc dependent manner in mice.
Transl Gastroenterol Hepatol
October 2024
Article Synopsis
- Hepatic ischemia and reperfusion (I/R) injury is a significant issue for patients undergoing liver-related surgeries, and this study investigates the protein REGγ's role in this injury.* -
- Through experiments on mice, the study found that knocking out REGγ reduced liver damage, inflammation, and apoptosis, while also improving mitochondrial function.* -
- The findings suggest that REGγ is crucial in protecting the liver from I/R injury, potentially through the mitochondrial p66shc signaling pathway.*
Article Synopsis
- The study focuses on developing advanced biointegrated strain gauges that monitor the biomechanics of soft tissues, which is crucial for biomedical research and clinical treatments.
- These new implantable and wearable sensors, made from ultrathin monocrystalline silicon, are designed to measure multi-directional strains in real-time, improving upon older methods that were limited to specific directions and conditions.
- Experimental and computational results demonstrate the sensors' ability to track various physiological metrics (like cardiac pulse and eye pressure) and their potential use in diagnosing heart conditions and other medical issues, highlighting their clinical importance as possibly biodegradable implants.
Article Synopsis
- Mesoporous ceria nanoparticles with ordered pores (O-MCNs) are more desirable than those with interparticle pores (I-MCNs) due to their uniform structure and enhanced performance.
- Current synthesis methods only yield I-MCNs, prompting researchers to investigate the pore formation mechanisms of I-MCNs for developing new techniques to create O-MCNs.
- This study analyzed an established I-MCN synthesis method and discovered that the assembly of small ceria nanoparticles leads to pore formation; these insights could guide future efforts to synthesize O-MCNs.
Article Synopsis
- Skeletal muscle growth in pigs is influenced by genetic and environmental factors, which also affects the quality of pork.
- The study uses full-length transcriptome sequencing to analyze different growth stages of a specific pig breed, aiming to identify key genes involved in muscle development.
- Findings include potential regulators of muscle growth, contributing to a better understanding of molecular mechanisms and aiding in the development of improved pig breeds for the livestock industry.
Black rot, caused by Xanthomonas campestris pv. campestris (Xcc) significantly affects the production of cabbage and other cruciferous vegetables. Plant antioxidant system plays an important role in pathogen invasion and is one of the main mechanisms underlying resistance to biological stress.
View Article and Find Full Text PDFEffect of hydrogen sulfide on cabbage photosynthesis under black rot stress.
Plant Physiol Biochem
March 2024
Article Synopsis
- Hydrogen sulfide (HS) is a potential signaling molecule that helps plants cope with both environmental and biological stresses, such as black rot (BR) caused by the bacteria Xanthomonas campestris pv. Campestris (Xcc).
- This study found that exogenous application of HS helps mitigate the negative effects of Xcc infection on photosynthesis in cabbage seedlings by improving chlorophyll content, gas exchange, and enzyme activities related to the Calvin cycle.
- Transcriptome analysis revealed that HS treatment leads to the upregulation of genes associated with photosynthesis, suggesting it enhances the plants' ability to photosynthesize and resist stress caused by Xcc.
Article Synopsis
- Intestinal ischemia-reperfusion injury (IIRI) is a dangerous condition that can lead to serious health issues, and this study explores the roles of specific proteins (PRMT6, FoxO3a, and Parkin) in this injury and cell death.
- The research established both an animal model and an in vitro cell model to study the effects of ischemia-reperfusion, utilizing various techniques to assess cell death and protein changes.
- Findings indicated that PRMT6 regulates FoxO3a, which in turn controls Parkin levels, suggesting that enhancing PRMT6 could help reduce cell apoptosis during IIRI by maintaining the balance of pro-apoptotic and anti-apoptotic proteins.
Article Synopsis
- * This study is a single-blinded, randomized trial comparing the effects of liposomal bupivacaine and ropivacaine on POD and postoperative pain in elderly patients undergoing hip fracture surgery.
- * Ethical approval has been obtained for the study, which adheres to SPIRIT guidelines, and data is planned to be shared publicly by July 2029 through the China Clinical Trial Registry.
Article Synopsis
- Fast-growing broilers in Northeast China are commonly fed high-fat diets, with bile acids (BA) playing a role in fat digestion and muscle growth, but their effects are not fully understood.
- In a study, broilers fed a high-fat diet with BA showed significantly higher body weight and daily weight gain, along with improved feed conversion rates compared to those on high-fat diets without BA.
- The benefits of BA supplementation included increased lipase activity, enhanced breast muscle growth, and higher levels of key growth factors, suggesting that BA can optimize growth in broilers on high-fat diets.
Article Synopsis
- - A new CREMS algorithm is introduced to enhance the efficiency of emergency material scheduling across different regions through seed optimization techniques.
- - The approach uses a grid distribution model and a grid matching algorithm to create an optimization objective, while employing a variable neighborhood search to address clustering issues in scheduling.
- - By integrating deep learning and reinforcement learning, the method improves the design of optimal routes and configurations for emergency material management, yielding better performance in flexibility, path optimization, and spatial planning.
Article Synopsis
- Automatic multi-organ segmentation is crucial for diagnosing diseases and planning treatments, and the MSCT-UNET hybrid network combines CNN and transformer features to enhance segmenting capabilities.
- The network utilizes multi-task contrastive learning and a cross fusion block, allowing it to capture both detailed pixel-level features and long-range dependencies in medical images.
- Evaluation on multiple datasets shows that MSCT-UNET outperforms existing methods, with the source code available for public access.
Article Synopsis
- In aging mammals, there's a notable decline in naïve T cells and an increase in memory T cells, largely due to thymic involution, but the exact mechanisms behind these changes are not fully understood.
- Research involving T-cell-specific Rip1 knockout mice revealed that these mice exhibit accelerated aging signs, such as chronic inflammation and a shorter lifespan, alongside typical age-related changes in T cells.
- Blocking excessive T cell apoptosis in these Rip1-deficient mice can restore balance to their T cell populations and improve overall health and longevity, highlighting the significance of T cell maintenance for healthy aging.
Article Synopsis
- Multi-component composite materials that combine magnetic and dielectric properties show great promise for absorbing electromagnetic waves, but designing these structures effectively is challenging.
- This study successfully creates a high-performance composite material called MoS@GdO/Mxene loaded porous carbon aerogel (MGMCA) using wood, achieved through a special hydrothermal and carbonization process.
- The MGMCA features a smart structural design that enhances its electromagnetic wave absorption capabilities, achieving a remarkable minimum reflection loss of -57.5 dB with just a 1.9 mm thickness, offering new insights for developing biomass-based absorbent materials.
Article Synopsis
- - The study investigates how preconditioning with nasal splints and mouth-breathing training can prevent emergence delirium (ED) after general anesthesia in patients undergoing endoscopic sinus surgery (ESS).
- - In a trial with 200 patients, those who received the intervention had a significantly lower incidence of ED (16.3%) compared to those who received standard care (35.6%).
- - Key risk factors for developing ED included being male, smoking, and undergoing functional endoscopic sinus surgery, emphasizing the effectiveness of the preconditioning methods used.
Article Synopsis
- Oxidative stress (OS) results from too many free radicals and can damage the jejunum in piglets; this study focuses on how long noncoding RNAs (lncRNAs) change under such stress.
- Researchers induced OS in piglets using diquat and analyzed lncRNA expression through RNA sequencing, validating findings with qRT-PCR.
- A total of 79 lncRNAs were differentially expressed due to OS, with links to various biological pathways including cancer and signaling processes, paving the way for further research on jejunum responses to oxidative stress.*
Article Synopsis
- * Exposure to AFB1 harmed the growth and immune function of shrimp, leading to DNA damage and disrupting cell cycles by affecting specific pathways, alongside notable histological damage.
- * The introduction of bile acids in the shrimp's diet showed promise in reducing AFB1 levels and mitigating its harmful effects, suggesting that bile acids could play a protective role against AFB1 toxicity.