Causal role of common autoimmune diseases in interstitial cystitis/bladder pain syndrome: Mendelian randomization (MR) study.

Observational studies suggest that interstitial cystitis/bladder pain syndrome (IC/BPS) indices might be influenced by autoimmune diseases (AIDs), though it is difficult to infer causal relationships based on observational data due to risk of residual confounding. We utilized Mendelian randomization (MR) to explore causal relevance of multiple AIDs on IC/BPS. Our bidirectional two-sample MR analysis was based on summary statistics from the most recent and comprehensive genome-wide association studies.

Plasma tsRNA Signatures Serve as a Novel Biomarker for Bladder Cancer.

Bladder cancer (BLCA) is one of the most common tumors of the urinary tract. The diagnosis of BLCA is mostly by invasive tests, which are damaging and unsuitable for early screening. Current non-invasive diagnostic modalities are insufficient in sensitivity and specificity.

Single-Cell Multiomics Identifies Glycan Epitope LacNAc as a Potential Cell-Surface Effector Marker of Peripheral T Cells in Bladder Cancer Patients.

Cancer is a systemic disease continuously monitored and responded to by the human global immune system. Peripheral blood immune cells, integral to this surveillance, exhibit variable phenotypes during tumor progression. Glycosylation, as one of the most prevalent and significant post-translational modifications of proteins, plays a crucial role in immune system recognition and response.