Stereoactive Lone-Pair Manipulation for High Thermoelectric Performance of GeSe-Based Compounds.

Materials with high crystallographic symmetry are supposed to be good thermoelectrics because they have high valley degeneracy () and superb carrier mobility (μ). Binary GeSe crystallizes in a low-symmetry orthorhombic structure accompanying the stereoactive 4s lone pairs of Ge. Herein, we rationally modify GeSe into a high-symmetry rhombohedral structure by alloying with GeTe based on the valence-shell electron-pair repulsion theory.

Tantalum-stabilized ruthenium oxide electrocatalysts for industrial water electrolysis.

The iridium oxide (IrO) catalyst for the oxygen evolution reaction used industrially (in proton exchange membrane water electrolyzers) is scarce and costly. Although ruthenium oxide (RuO) is a promising alternative, its poor stability has hindered practical application. We used well-defined extended surface models to identify that RuO undergoes structure-dependent corrosion that causes Ru dissolution.

Topological transformation of microbial proteins into iron single-atom sites for selective hydrogen peroxide electrosynthesis.

The emergence of single-atom catalysts offers exciting prospects for the green production of hydrogen peroxide; however, their optimal local structure and the underlying structure-activity relationships remain unclear. Here we show trace Fe, up to 278 mg/kg and derived from microbial protein, serve as precursors to synthesize a variety of Fe single-atom catalysts containing FeNO (1 ≤ x ≤ 4) moieties through controlled pyrolysis. These moieties resemble the structural features of nonheme Fe-dependent enzymes while being effectively confined on a microbe-derived, electrically conductive carbon support, enabling high-current density electrolysis.

Configurational paths to promoting children's agility and balance quality: based on fuzzy-set qualitative comparative analysis.

Background: Early childhood is a sensitive period for the development of agility and balance quality. Currently, children's agility and balance quality are gradually declining, and the pathways for enhancing these qualities are limited. In light of this, the study adopts a set theory perspective to explore the configurational pathways through which subsystems of gross motor skills can promote children's agility and balance quality.

Operando Observation of Electrically Triggered Phase Transition in Thin CuS Crystal.

CuS has been identified as a functional material of memristors with multilevel resistance switching. However, as the migration of Cu ions under the electric field is tangled with defect evolution and phase transition, the electroresistance mechanism of CuS remains largely unclear. Here, the electrically triggered phase transition was studied by transmission electron microscopy.

Connectome-based predictive modelling of ageing, overall cognitive functioning and memory performance.

Resting-state functional magnetic resonance imaging (rs-fMRI) and brain functional connectome (we use 'brain connectome' hereafter for simplicity) have advanced our understanding of the ageing brain and age-related changes in cognitive function. Previous studies have investigated the association among brain connectome and age, global cognition, and memory function separately. However, very few have predicted age, overall cognitive functioning and memory performance in a single study to better understand their complex relationship.

In Situ STEM Observation of Phase Transition Triggered by Mo Migration in MoTe.

The heterostructure of transition metal dichalcogenides (TMDs), such as one-dimensional (1D) nanowires embedded in two-dimensional (2D) nanosheets, has drawn much research attention due to its unique electronic, spintronic, magnetic, and catalytic properties. The general approach for preparing such a heterostructure is through electron beam lithography or annealing on the 2D template, triggering direct formation of the 1D component within the 2D matrix. However, the thermodynamic mechanism behind the transition from 2D to 1D is still not well clarified.

Suppression of Structural Heterogeneity in High-Entropy Intermetallics for Electrocatalytic Upgrading of Waste Plastics.

The key to fully realizing the potential of high-entropy alloys (HEAs) lies in balancing their inherent local chemical disordering with the long-range ordering required for electrochemical applications. Herein, we synthesized a distinctive L1-(PtIr)(FeMoBi) high-entropy intermetallics (HEIs) exhibiting nanoscale long-range order and atomic scale short-range disorder via a lattice compensation strategy to mitigate the entropy reduction tendency. The (PtIr)(FeMoBi) catalyst exhibited remarkable activity and selectivity of glycollic acid (GA) production via electrocatalytic waste polymer-derived ethylene glycol oxidation reaction (EGOR).

Integrating few-atom layer metal on high-entropy alloys to catalyze nitrate reduction in tandem.

While high-entropy alloy (HEA) catalysts seem to have the potential to break linear scaling relationships (LSRs) due to their structural complexity, the weighted averaging of properties among multiple principal components actually makes it challenging to diverge from the symmetry dependencies imposed by the LSRs. Herein, we develop a 'surface entropy reduction' method to induce the exsolution of a component with weak affinity for others, resulting in the formation of few-atom-layer metal (FL-M) on the surface of HEAs. These exsolved FL-M surpass the confines of the original configurational space of conventional HEAs, and collaborate with the HEA substrate, serving as geometrically separated active sites for multiple intermediates in a complex reaction.

Entropy-increased LiMnO-based positive electrodes for fast-charging lithium metal batteries.

Fast-charging, non-aqueous lithium-based batteries are desired for practical applications. In this regard, LiMnO is considered an appealing positive electrode active material because of its favourable ionic diffusivity due to the presence of three-dimensional Li-ion diffusion channels. However, LiMnO exhibits inadequate rate capabilities and rapid structural degradation at high currents.

Evolution of Neurosurgical Robots: Historical Progress and Future Direction.

In 1985, Professor KWOH first introduced robots into neurosurgery. Since then, advancements of stereotactic frames, radiographic imaging, and neuronavigation have led to the dominance of classic stereotactic robots. A comprehensive retrieval was performed using academic databases and search agents to acquire professional information, with a cutoff date of June, 2024.

Jasmonate/ethylene- and NaWRKY6/3-regulated Alternaria resistance depends on ethylene response factor 1B-like in Nicotiana attenuata.

Biosynthesis of the phytoalexins scopoletin and scopolin in Nicotiana species is regulated by upstream signals including jasmonate (JA), ethylene (ET), and NaWRKY3 in response to the necrotrophic fungus Alternaria alternata, which causes brown spot disease. However, how these signals are coordinated to regulate these phytoalexins remains unknown. By analyzing RNA sequencing data and RNAi, we identified NaERF1B-like (NaERF1B-L) as a key player in Nicotiana attenuata during A.

Two-Dimensional-Like Phonons in Three-Dimensional-Structured Rhombohedral GeSe-Based Compounds with Excellent Thermoelectric Performance.

The coupling of charge and phonon transport in solids is a long-standing issue for thermoelectric performance enhancement. Herein, two new narrow-gap semiconductors with the same chemical formula of GeSeTe (GST) are rationally designed and synthesized: one with a layered hexagonal structure (H-GST) and the other with a non-layered rhombohedral structure (R-GST). Thanks to the three-dimensional (3D) network structure, R-GST possesses a significantly larger weighted mobility than H-GST.

Rational Design of Cu Vacancies and Antisite Defects for Boosting the Thermoelectric Properties of CuGaTe-Based Compounds.

CuGaTe-based compounds show great promise in the application for high-temperature thermoelectric power generation; however, its wide bandgap feature poses a great challenge for enhancing thermoelectric performance via structural defects modulation and doping the system. Herein, it is discovered that the presence of Ga antisite defects in the CuGaTe compound promotes the formation of Cu vacancies, and vice versa, which tends to form the charge-neutral structure defects combination with one Ga antisite defect and two Cu vacancies. The accumulation of Cu vacancies in the structure of the (CuTe)(GaTe) compounds evolves into twins and stacking faults.

High Ductility and Excellent Thermoelectric Performance in Te-Stabilized Cubic AgTeS Solid Solutions.

The stabilization at low temperatures of the AgS cubic phase could afford the design of high-performance thermoelectric materials with excellent mechanical behavior, enabling them to withstand prolonged vibrations and thermal stress. In this work, we show that the AgTeS solid solutions, with Te content within the optimal range 0.20 ≤ ≤ 0.

FZ-AD005, a Novel DLL3-Targeted Antibody-Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models.

Delta-like ligand 3 (DLL3) is overexpressed in small cell lung cancer (SCLC) and has been considered an attractive target for SCLC therapy. Rovalpituzumab tesirine was the first DLL3-targeted antibody-drug conjugate (ADC) to enter clinical studies. However, serious adverse events limited progress in the treatment of SCLC with rovalpituzumab tesirine.

Targeting the Ophthalmic Diseases Using Extracellular Vesicles 'Exosomes': Current Insights on Their Clinical Approval and Present Trials.

Ophthalmic diseases encompass a diverse range of conditions, each necessitating tailored treatment strategies. In the realm of ophthalmic research and therapeutic interventions, various subtypes of exosomes are being explored for their regenerative, neuroprotective, and anti-inflammatory properties. Exosomes have garnered increasing attention as promising therapeutic vehicles due to their natural role in cell-to-cell communication and targeted delivery capabilities.

General synthesis of ionic-electronic coupled two-dimensional materials.

Two-dimensional (2D) AMX compounds are a family of mixed ionic and electronic conductors (where A is a monovalent metal ion, M is a trivalent metal, and X is a chalcogen) that offer a fascinating platform to explore intrinsic coupled ionic-electronic properties. However, the synthesis of 2D AMX compounds remains challenging due to their multielement characteristics and various by-products. Here, we report a separated-precursor-supply chemical vapor deposition strategy to manipulate the chemical reactions and evaporation of precursors, facilitating the successful fabrication of 20 types of 2D AMX flakes.