Nitric Oxide-Releasing Mesoporous Hollow Cerium Oxide Nanozyme-Based Hydrogel Synergizes with Neural Stem Cell for Spinal Cord Injury Repair.

Neural stem cell (NSCs) transplantation is a promising therapeutic strategy for spinal cord injury (SCI), but its efficacy is greatly limited by the local inhibitory microenvironment. In this study, based on l-arginine (l-Arg)-loaded mesoporous hollow cerium oxide (AhCeO) nanospheres, we constructed an injectable composite hydrogel (AhCeO-Gel) with microenvironment modulation capability. AhCeO-Gel protected NSCs from oxidative damage by eliminating excess reactive oxygen species while continuously delivering Nitric Oxide to the lesion of SCI in a pathological microenvironment, the latter of which effectively promoted the neural differentiation of NSCs.

The spatiotemporal patterns of the beet webworm (Lepidoptera: Crambidae) in China and possible dynamics under future climate scenarios.

The beet webworm (BWW), Loxostege sticticalis (L.), is a notorious migratory agriculture pest of crops and fodder plants, inducing sudden outbreaks and huge losses of food and forage production. Quantifying its spatiotemporal patterns and possible dynamics under future climate scenarios may have significant implications for management policies and practices against this destructive agriculture pest.

A Catalytic Enantioselective Suzuki Coupling for the Modular Construction of Axially Chiral BODIPYs with Bright Solid-State Emission.

The development of chiral BODIPYs attracts remarkable interest due to their unique properties, structural diversity, and good photochemical stability, whereas achieving the construction of chiral BODIPYs maintains scarce. Herein, we present an enantioselective synthesis of axially chiral BODIPYs through Suzuki-Miyaura coupling. The newly synthesized chiral BODIPYs and the coassembly showed desirable photophysical properties, including high fluorescence quantum yields and intense CPL, both in solution and the solid state.

Effects of functionalized nanoplastics on oxidative stress in the mussel Mytilus coruscus.

In the marine environment, various weathering effects on micro or nanoplastics lead to surface modifications, which in turn alter their toxic effects on aquatic organisms. This study investigated the impact of three types of nanoplastics (NPs, NPs-NH, NPs-COOH) on the antioxidant capacity of Mytilus coruscus gills, mantle, and hemolymph over 28 days. Analyzed key antioxidant stress indicators (CAT, SOD, GSH, GSH-Px, MDA, HO) and conducted IBR and PCA analyses to evaluate the toxic effects of modified nanoplastics.

Diversity and role of volatile terpene and terpenoid pheromones in insects.

Insect pheromones are critical chemical signals that regulate intraspecific behavior and play a key role in the dynamic monitoring and control of pest populations. Historically, research on insect pheromones has primarily focused on lipid-based compounds. However, terpenes and terpenoids, which are widely occurring classes of bioactive compounds, also play significant roles in insect pheromone blends.

MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2.

Breast carcinoma exhibits the highest incidence among various cancers and is the foremost cause of mortality in women. Increasing evidence shows that SUMOylation of proteins plays a critical role in the progression of breast cancer; however, the role of SENP2 and its molecular mechanism in breast cancer remain underexplored. Here, we discerned that SENP2 promoted the tumorigenesis of breast cancer both in vitro and in vivo.

Nudge theories and strategies influencing adult health behaviors and outcomes in COPD management: a systematic review.

Objective: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease with high prevalence and mortality, and self-management is a key component for better outcomes of COPD. Recently, nudging has shown promising potential in COPD management. In the present study, we conducted a systematic review to collate the list of nudges and identified the variables that influence nudging.

Environmental Cationic Dye/Porous Silica Nanospheres for Printed Cotton Fabrics with Enhanced Coloration Performance.

The wastewater of printing and dyeing is difficult to treat due to the degradation resistance of dye and the use of massive chemicals, causing a threat to the ecosystem. Pigment printing of fabrics possesses great advantages like high efficiency and flexible production, but there are some challenges like the risk of color depth and hand feeling due to the large size of the pigment and poor adsorption of light. In order to improve the coloration ability of pigment, herein, a novel kind of cationic dye/porous silica nanospheres were prepared through the adsorption of methylene blue and rhodamine B onto electronegative porous silica nanospheres and applied in printing on woven cotton fabric.

The intra-tumoral microbiome as a potential biomarker of response to external beam radiation therapy in cervical cancer.

Background: We aimed to determine the potential predictive value of the intra-tumoral microbiome as a marker of the response to external beam radiation therapy (EBRT) in cervical cancer (CC).

Methods: A prospective longitudinal trial of 36 CC patients receiving pelvic radiotherapy was designed to investigate microbial characteristic signatures and diversity (alpha and beta) of multiple sites (tumor, vaginal, gut, urethral, and oral) in the superior response (SR) and inferior response (IR) groups of CC patients by 16S rRNA sequencing. Utilized the least absolute shrinkage and selection operator (LASSO) logistic regression method to analyze clinicopathological factors that potentially influenced the efficacy of EBRT.

A disproportionality analysis for assessing the safety of FLT3 inhibitors using the FDA Adverse Event Reporting System (FAERS).

Objectives: This pharmacovigilance analysis was conducted to assess the safety signals of FMS-related tyrosine kinase 3 (FLT3) inhibitors in a real-world setting using the United States Food and Drug Administration Adverse Event Reporting System (FAERS).

Design: We analyzed adverse event (AE) reports related to FLT3 inhibitors submitted to the FAERS database from the first quarter of 2015 to the fourth quarter of 2022. Disproportionality analysis was used to identify AEs of FLT3 inhibitors in the FAERS database.

Construction of knowledge sharing network indicator system for medication therapy management service training teams based on social network analysis.

Background: Based on the perspective of social network theory, this study explored the network indicator system that facilitated optimal knowledge sharing effect in Medication Therapy Management Services (MTMS) training teams. The aim was to provide a reference for optimizing MTMS training and improving training quality.

Methods: Utilizing social network analysis combined with a questionnaire survey, a knowledge sharing matrix for MTMS training teams was constructed.

Engineering Spacer Conjugation for Efficient and Stable 2D/3D Perovskite Solar Cells and Modules.

Incorporating two-dimensional (2D) perovskite in 3D perovskite absorber holds great potential to improve the stability and efficiency of perovskite solar cells (PSCs). However, the bulky-cation-based 2D structures often exhibit poor charge transport and are prone to formation of charge-extraction barrier that impedes efficient device operation. We address these issues by introducing aromatic spacers with molecular conjugation into 2D perovskites locating between 3D perovskites and electron charge transport layers.

Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells.

The HECT-type E3 ubiquitin WWP1 (also known as NEDD4-like E3 ubiquitin-protein ligase WWP1) acts as an oncogenic factor in acute myeloid leukemia (AML) cells. WWP1 overexpression in AML confers a proliferative advantage to leukemic blasts (abnormal immature white blood cells) and counteracts apoptotic cell death and differentiation. In an effort to elucidate the molecular basis of WWP1 oncogenic activities, we identified WWP1 as a previously unknown negative regulator of thioredoxin-interacting protein (TXNIP)-mediated reactive oxygen species (ROS) production in AML cells.

Antifungal activities of Equol against and .

is an opportunistic fungal pathogen that can cause systemic infections in immunocompromised individuals. Morphological transition and biofilm formation are major virulence factors of . Moreover, biofilm enhances resistance to antifungal agents.

SENP3 mediates the deSUMOylation and degradation of YAP1 to regulate the progression of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a prevalent malignancy in women, casting a formidable shadow on their well-being. Positioned within the nucleolus, SUMO-specific protease 3 (SENP3) assumes a pivotal role in the realms of development and tumorigenesis. However, the participation of SENP3 in TNBC remains a mystery.

Clarifying urban flood response characteristics and improving interpretable flood prediction with sparse data considering the coupling effect of rainfall and drainage pipeline siltation.

With climate warming and accelerated urbanisation, severe urban flooding has become a common problem worldwide. Frequent extreme rainfall events and the siltation of drainage pipes further increase the burden on urban drainage networks. However, existing studies have not fully considered the effects of rainfall and pipeline siltation on the response characteristics of flooding when constructing numerical models of urban flooding simulations.

Lifestyle, air pollution, and risk of multimorbidity in a prospective analysis of the UK Biobank cohort.

Background: Although associations between chronic obstructive pulmonary disease (COPD) or ischaemic heart disease (IHD) and lifestyle factors or air pollution factors (referred as LAFs below) are well-established, it is unclear the influences of LAFs on the trajectory of IHD and COPD multimorbidity (referred as ICM below). Therefore, this study investigated the influences of LAFs on the trajectory of ICM from healthy to IHD or COPD, to ICM, and to all-cause death.

Methods: A cohort of 339,213 participants from the UK Biobank aged 37-73 who were free of IHD and COPD were included.

Hepatitis B virus infection and the risk of gynecologic cancers: a systematic review and meta-analysis.

Objectives: The relationship between hepatitis B virus (HBV) infection and gynecologic cancers is controversial. We aimed to evaluate the risk of gynecologic cancers associated with HBV infection using a meta-analysis.

Methods: Two independent reviewers identified publications in the PubMed, Embase and Cochrane Library databases that reported an association between HBV and the risk of gynecologic malignancy from inception to December 31, 2022.

Splenic abscess secondary to COVID-19 acute infection: A case report and literature review.

Rationale: Splenic abscess is relatively rare in clinical practice as an invasive disease. However, during the continuous prevalence of coronavirus disease 2019 (COVID-19), the incidence rate of splenic abscess showed an upward trend. However, because the etiology of splenic abscess is not specific, it is easy to be covered by the respiratory symptoms of COVID-19, resulting in omission or delay in diagnosis.

Hedgehog signaling pathway regulates Th17 cell differentiation in asthma via IL-6/STAT3 signaling.

Asthma is the most prevalent chronic inflammatory disease of the airways in children. The most prevalent phenotype of asthma is eosinophilic asthma, which is driven by a Th2 immune response and can be effectively managed by inhaled corticosteroid therapy. However, there are phenotypes of asthma with Th17 immune response that are insensitive to corticosteroid therapy and manifest a more severe phenotype.

Operationally stable perovskite solar modules enabled by vapor-phase fluoride treatment.

The ever-increasing power conversion efficiency of perovskite solar cells has illuminated the future of the photovoltaic industry, but the development of commercial devices is hampered by their poor stability. In this study, we report a scalable stabilization method using vapor-phase fluoride treatment, which achieves 18.1%-efficient solar modules (228 square centimeters) with accelerated aging-projected lifetimes (time to 80% of efficiency remaining) of 43,000 ± 9000 hours under 1-sun illumination at 30°C.

DARS expression in BCR/ABL1-negative myeloproliferative neoplasms and its association with the immune microenvironment.

DARS, encoding for aspartyl-tRNA synthetase, is implicated in the pathogenesis of various cancers, including renal cell carcinoma, glioblastoma, colon cancer, and gastric cancer. Its role in BCR/ABL1-negative myeloproliferative neoplasms (MPNs), however, remains unexplored. This study aimed to elucidate the expression of DARS in patients with MPNs (PV 23, ET 19, PMF 16) through immunohistochemical analysis and to examine the profiles of circulating immune cells and cytokines using flow cytometry.

ScHGSC-IGDC: Identifying genes with differential correlations of high-grade serous ovarian cancer based on single-cell RNA sequencing analysis.

Due to the high heterogeneity of ovarian cancer (OC), it occupies the main cause of cancer-related death among women. As the most aggressive and frequent subtype of OC, high-grade serous cancer (HGSC) represents around 70 % of all patients. With the booming progress of single-cell RNA sequencing (scRNA-seq), unique and subtle changes among different cell states have been identified including novel risk genes and pathways.

Identification of prognostic risk model based on plasma cell markers in hepatocellular carcinoma through single-cell sequencing analysis.

Hepatocellular carcinoma (HCC) represents a substantial global health burden. Tumorinfiltrating B lymphocytes (TIL-Bs) contribute to tumor progression and significantly impact the efficacy of tumor therapy. However, the characteristics of TIL-Bs in HCC and their effect on HCC therapy remain elusive.