A study on surrounding rock characteristics inducing severe large deformation in tunnels and methods for determining its strength.

The Haba Snow Mountain Tunnel experienced severe deformation caused by foliated metamorphic basalt. This rock has high metamorphism, easy weathering, and low strength. This study examines the rock's microscopic characteristics and mechanical properties to understand its impact on tunnel stability and offer guidance for similar engineering challenges.

Subchronic Toxicity Test of Transgenic Herbicide-Tolerant Soybean ZH10-6 in Rats.

The herbicide-tolerant soybean ZH10-6 was developed by modifying the Zhonghuang 10 (ZH10) variety with the G2-EPSPS and GAT genes, conferring resistance to glyphosate. This study aimed to assess the potential health effects of ZH10-6 in Sprague-Dawley rats through a 90-day subchronic toxicity test. Seven groups of rats (n = 10/sex/group) were fed a commercial AIN93G diet or diets containing 7.

Adjuvant non-opioid analgesics decrease in-hospital mortality in targeted patients with acute pancreatitis receiving opioids.

Objectives: Opioid administration in acute pancreatitis (AP) exacerbates its severity, prompting concerns regarding the increased requirement for intensive care and its potential impact on patient survival. We aimed to elucidate the influence of analgesic patterns on mortality among patients with AP hospitalized in the ICU.

Methods: We included 784 patients (198 receiving opioid monotherapy and 586 receiving opioid polytherapy) from the Medical Information Mart for Intensive Care database.

Progress in enzyme-powered micro/nanomotors in diagnostics and therapeutics.

Enzyme-powered micro/nanomotors (EMNMs) represent cutting-edge research taking advantage of enzymes as biocatalysts to provide a driving force for micro/nanomotors. Up to now, EMNMs have been designed to be powered by catalase, urease, lipase, collagenase, compound enzymes, . They not only have good biocompatibility and biosafety but also possess the unique ability to utilize physiologically relevant fuel to achieve autonomous propulsion through catalytic reactions.

Bubble Nucleation and Heat Transfer on Three-Dimensional Mixed-Wettable Nanostructured Surfaces: A Molecular Dynamics Study.

This study explores the bubble nucleation process and heat transfer characteristics on nanostructured solid surfaces with mixed-wettable pillars using molecular dynamics simulations. Five different surfaces were designed by varying the wettability of the central pillars while keeping the lateral pillars hydrophilic. The nucleation behavior of argon bubbles was observed to differ significantly across these surfaces due to the combined effects of nanostructuring and mixed wettability.

[Anti-tumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice].

Objective: To explore the antitumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice in vivo and its possible mechanism.

Methods: 4T1 tumor-bearing mice model was established. After successful modeling, tumor-bearing mice were randomly divided into model control group, cyclophosphamide(CTX) positive group, and high, medium and low dose groups of Inonotus obliquus extract, with 10 mice in each group, which were administered continuously for 21 days.

Ninety-Day Feeding Test of Stacked DBN9936 × DBN9501 Maize on Sprague Dawley Rats.

The transgenic maize DBN9936 × DBN9501, which confers resistance to insects and tolerance to herbicides, was developed via conventional cross breeding of transgenic maize DBN9936 and DBN9501. In our present study, a 90-day feeding toxicity study was conducted on Sprague Dawley rats to evaluate the safety of the maize. A total of 140 rats were randomly assigned to seven groups (n = 10/sex/group): one control group, three genetically modified (GM) groups with 17.

Impact of Early Ying Yang Bao Nutritional Support on Growth and Neurodevelopment in Preschool Children in China.

: Providing early nutritional support through Ying Yang Bao (YYB) can assist children in achieving their full developmental potential. We aimed to examine the lasting impact of YYB and how growth affects neurodevelopment in preschool children. : 1104 children aged 1 year were divided into a YYB control group (YYB-CG) and a YYB intervention group (YYB-IG).

Exosome applications for the diagnosis and treatment of pancreatic ductal adenocarcinoma: An update (Review).

Pancreatic ductal adenocarcinoma (PDAC) is a malignant neoplasm that typically manifests with subtle clinical manifestations in its early stages and frequently eludes diagnosis until the advanced phases of the disease. The limited therapeutic options available for PDAC significantly contribute to its high mortality rate, highlighting the urgent need for novel biomarkers capable of effectively identifying early clinical manifestations and facilitating precise diagnosis. The pivotal role of cellular exosomes in both the pathogenesis and therapeutic interventions for PDAC has been underscored.

Soybean Agglutinin Induced Apoptotic Effects by Down-Regulating ANXA2 Through FAK Pathway in IPEC-J2 Cells.

Soybean agglutinin (SBA) is an anti-nutritional factor in soybean, possesses toxic effects by binding to intestinal epithelial cells, and finally interferes the digestion and absorption of nutrients in humans and animals. Annexin A2 (ANXA2) is one of the SBA-specific binding proteins in intestinal epithelial cells and participates in multiple cellular biological processes. However, whether SBA affects apoptosis through ANXA2 and its apoptosis-related pathway remains unclear.

Hydrogen Peroxide Heterolytic Cleavage Induced Gas Phase Photo-Fenton Oxidation of Nitric Oxide.

Nitric oxide (NO) is one of the major air pollutants that may cause ecological imbalance and severe human disease. However, the removal of NO faces challenges of low efficiency, high energy consumption, and production of toxic NO byproducts. Herein, we report an efficient *OOH intermediate-involved NO oxidation route with high NO selectivity via a gas phase photo-Fenton system.

The effectiveness and safety of botulinum toxin injections for managing motor disorders of patients with Parkinson's disease: A meta-analysis of randomized controlled trials.

This study aimed to assess the effectiveness and safety of botulinum toxin (BTX) injections for managing motor disorders in patients with Parkinson's disease (PD). An electronic search was conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from available randomized controlled trials (RCTs) assessing BTX injections for motor disorders in PD patients were extracted for meta-analysis.

Palladium-Catalyzed Cross-Coupling of Aryl Bromides and Chlorides with Trimethylsilylalkynes under Mild Conditions.

Herein, we disclose a palladium-catalyzed cross-coupling of aryl bromides and chlorides with trimethylsilylalkynes under mild reaction conditions. This method utilizes commercially available and air stable palladium precatalysts and avoids the use of copper cocatalysts. Moreover, it allows for the synthesis of a wide range of disubstituted alkynes in high yields with excellent functional group tolerance.

Support mechanical response analysis and surrounding rock pressure calculation method for a shallow buried super large section tunnel in weak surrounding rock.

At present, China's demand for high-speed railway construction is constantly increasing, and the construction of Multi line high-speed railway tunnels has been put on the agenda. The design and construction issues of super-large-sections tunnels urgently need to be addressed. The Xiabei mountain No.

Potential distribution prediction of Ceracris kiangsu Tsai in China.

Ceracris kiangsu Tsai (C. kiangs) is a kind of forest pest, which can harm nearly 100 kinds of weeds and crops. In this study, based on 314 species distribution points of C.

Research on stress field inversion and large deformation level determination of super deep buried soft rock tunnel.

Understanding the characteristics and distribution patterns of the initial geo-stress field in tunnels is of great significance for studying the problem of large deformation of tunnels under high geo-stress conditions. This article proposes a ground stress field inversion method and large deformation level determination based on the GS-XGBoost algorithm and the Haba Snow Mountain Tunnel of the Lixiang Railway. Firstly, the hydraulic fracturing method is used to conduct on-site testing of tunnel ground stress and obtain tunnel ground stress data.

Relation between Polygenic Risk Score, Vitamin D Status and BMI-for-Age Score in Chinese Preschool Children.

Background: Both genetics and vitamin D deficiency are associated with childhood obesity. However, the role of vitamin D status between polygenic and childhood obesity has been unknown. The current study aimed to determine the relation between genetic factors, vitamin D status, and BMI-for-age score (zBMI) in Chinese preschool children.

Safety assessment of transgenic maize CC-2 by 90-day feeding study in Sprague-Dawley rats.

Objective: The purpose of this study was to assess the safety of transgenic maize CC-2 through a 90-day feeding study in Sprague-Dawley rats.

Methods: Transgenic maize CC-2 and its parental counterpart maize Zhengdan 958 were respectively incorporated into diets at levels of 70%, 35% or 17.5% (w/w) and were administrated to rats (n = 10/sex/group) for 90 days.

Geographical distribution of two major quarantine fruit flies ( Enderlein and Hendel) in Sichuan Basin based on four SDMs.

Both and are phytophagous insects, and their larvae are latent feeders, which cause great damage and economic losses to agriculture production and trade. This study aimed to provide a scientific reference for researching and developing the feasible countermeasures against these two pests. Based on the distribution data of and in China, obtained from the Chinese herbaria, investigation and literature.

Advancements in the Evolution of Engineering Characteristics and Reinforcement Technologies for Subgrade Silt.

Technical challenges associated with the treatment of silt subgrades frequently arise in coastal and river delta areas. Given the importance of environmental sustainability, the selection of efficient, cost-effective, and eco-friendly techniques for silt subgrade stabilization is paramount. While recycled polyester fibers primarily sourced from discarded polyester bottles have not yet been systematically employed in silt subgrade reinforcement, their potential is considerable.

Surface settlement law of double-hole pipe-jacking tunnel undercrossing expressway.

With the rapid urbanization process in China, there has been a significant development of urban underground spaces. The pipe-jacking method has gained popularity in various projects due to its advantages such as short construction period, adaptability to different soil conditions, and minimal excavation disturbance. This study focuses on a tunnel project involving double-hole rectangular pipe-jacking under an expressway.