Publications by authors named "JinMing Sun"

Peptide self-assembly is a complex hierarchical process involving the progressive formation of secondary structures, such as α-helices, β-sheets, and turns, during the early stages. It is precisely these multi-component building blocks that contribute to the complexity of protein assemblies in living organisms. While coiled coils are well-understood in protein folding, determining the structural characteristics governing their lateral packing remains challenging.

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The poly(L-lactic acid) (PLLA)/ZnO composite membrane with cluster assemblies microstructure was constructed by a combination of non-solvent induced phase separation (NIPS) and the Breath-Figure method. In this novel method, the controllable diffusion rate between solvent and non-solvent was introduced to the system by adjusting the non-solvent solubility parameters. The humidity was adjusted to control non-solvent solubility parameters in the Breath-Figure method, which avoids the instantaneous phase separation induced by direct coagulation of water droplets.

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In nature, biochemical processes depend on polymorphism, a phenomenon by which discrete biomolecules can adopt specific conformations based on their environment. However, it is often difficult to explore the generation mechanism and achieve polymorphic control in artificial supramolecular assembly systems. In this work, we propose a feasible thought for exploring the transformation mechanism of polymorphism in peptide assembly from the perspective of thermodynamic regulation, which enables polymorphic composition to be limited by switchable intramolecular CH⋯π attraction within a certain temperature range.

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  • - Histidine plays key roles in proteins but is less studied than other amino acids like lysine and cysteine, especially regarding its post-translational modifications (PTMs).
  • - The research introduces a new reaction using visible light to activate thioacetals, allowing for targeted modification of histidine residues in proteins under biocompatible conditions.
  • - This method successfully identified 78 proteins rich in histidine that may be involved in metal accumulation related to brain diseases, highlighting histidine’s significance in protein functions and expanding tools for protein modification.
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  • Distal metastases significantly lower the prognosis for colorectal cancer patients, with around 95% of these cancers being DNA mismatch repair proficient (pMMR).
  • Previous research indicates that the microRNA miR-6511b-5p is less expressed in pMMR cases, but its specific role in cancer metastasis remained unclear.
  • Experimental studies showed that miR-6511b-5p can inhibit metastasis by reducing the expression of CD44 through direct interaction with BRG1, suggesting it could serve as a potential biomarker and treatment target for metastatic pMMR colorectal cancer.
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  • The study investigates mitochondrial tRNA mutations as causes of maternally inherited hypertension in a Han Chinese family, revealing a poorly understood pathophysiological link between these mutations and hypertension. !* -
  • Analysis of mitochondrial genomes identified three potential pathogenic mutations (T7561C, C12153T, A12172G) associated with varying degrees of hypertension among family members, suggesting a connection between tRNA dysfunction and hypertension. !* -
  • The research concludes that while these mitochondrial mutations are linked to hypertension, they are not solely responsible, indicating that other factors such as environmental influences and nuclear genetics may also play a significant role in the disease's manifestation. !*
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Comprehending the biology of tumorigenesis needs identification of determinants of the immune reaction during cancer development. This study intends to illustrate the mechanistic actions of a bioinformatically predicted circRNA circ_002172 in cytotoxic T lymphocytes (CTL) infiltration and escape of breast cancer (BC) from immunological destruction. Expression patterns of circ_002172, miR-296-5p, and CXCL12 were determined in BC tissues and cells.

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A novel amidation strategy using electrophilic sulfonium, which is soluble and stable in aqueous conditions, was developed. The sulfoniums could activate thioacid and carboxyl acid to efficiently react with amines to afford amides. This method enables applications in amidation in both aqueous media and solid-phase peptide synthesis, peptide/protein modifications, and reactive lysines of a proteome at pH 10 with activity-based protein profiling.

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Cancer metastasis is a major cause of death among women afflicted with breast cancer (BC) and understanding the molecular processes involved is a major focus in BC research. Circular RNAs (circRNAs) have emerged as genomic regulatory molecules in carcinogenesis and metastasis; however, their role in BC is unclear. We characterized a novel circRNA, hsa_circ_0000515, in context of BC.

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In this paper, it is proposed that the central nervous system (CNS) controls human gait using a predictive control approach in conjunction with classical feedback control instead of exclusive classical feedback control theory that controls based on past error. To validate this proposition, a dynamic model of human gait is developed using a novel predictive approach to investigate the principles of the CNS. The model developed includes two parts: a plant model that represents the dynamics of human gait and a controller that represents the CNS.

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Background: Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder of unknown etiology which can cause diffuse alveolar hemorrhage. IPH is found primarily in children. In adults, however, it is extremely rare.

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Article Synopsis
  • A powered ankle-foot prosthesis was developed and tested with amputee subjects to evaluate its effectiveness compared to passive prostheses and natural able-bodied walking.
  • The testing revealed that the powered prosthesis successfully generated active ankle moments during the stance phase and helped with foot clearance during the swing phase, contributing to a more natural walking experience for users.
  • Despite these positive results, the powered prosthesis was found to be slightly less powerful than a natural ankle during movement.
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Sweet potato starch residue (SPSR) was used as starting material to prepare an eco-friendly adsorbent. SPSR was modified by bromoacetyl bromide to obtain a macroinitiator for surface-initiated single electron transfer-living radical polymerization (SI-SET-LRP) of acrylonitrile (AN) catalyzed by La(0)/hexamethylenetetramine (HMTA) in N,N-dimethylformamide (DMF) in the presence of ascorbic acid (VC). The amidoxime (AO) adsorbent was prepared by the reaction of the graft copolymer bromoactylated sweet potato starch (BSPS)/polyacrylonitrile (BSPS-g-PAN) with hydroxylamine.

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  • The paper explores the behavior of a spherical absorber in water when influenced by laser energy, showcasing its ability to display complex and chaotic dynamics.
  • Through computer experiments, the authors analyze how variations in laser pulse duration and energy lead to a transition from periodic pressure responses to spatiotemporal chaos.
  • These findings offer theoretical insights into fluid dynamics and turbulence, while also having practical implications for applications in material science and biomedicine.
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Damage by pulsed lasers to the retina or other tissues containing strongly absorbing particles may occur through biophysical mechanisms other than simple heating. Shockwaves and bubbles have been observed experimentally, and depending on pulse duration, may be the cause of retinal damage at threshold fluence levels. We perform detailed calculations on the shockwave and bubble generation expected from pulsed lasers.

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