Identification of genetic loci and candidate genes underlying Fusarium crown rot resistance in wheat.

A major locus Qfcr.cau-1B conferring resistance to Fusarium crown rot was identified and validated. The putative gene underlying this locus was pinpointed via virus-induced gene silencing.

Liquid nitrogen quenching for efficient Bifunctional electrocatalysts in water Splitting: Achieving four key objectives in one step.

Herein, a novel liquid nitrogen quenching treatment is proposed to achieve multifaceted modulation involving morphological modulation, lattice tensile strain modulation, metal active centre coordination reconstruction and grain boundary construction within a series of intermetallic compounds modified on a carbon substrate (CoFe-550/C, CoNi-550/C and FeNi-550/C, where 550 refers to liquid nitrogen quenching temperature and C refers to the carbon substrate). Noteworthily, the optimising intermediate absorption/desorption process is achieved by multifaceted modulation. Consequently, CoFe-550/C, CoNi-550/C and FeNi-550/C demonstrate considerable overpotential for hydrogen evolution reaction (59.

The Association Between Brominated Flame Retardants Exposure and Liver-Related Biomarkers in US Adults.

Emerging studies demonstrate that exposure to brominated flame retardants (BFRs) can have harmful effects on human health. Our study focused on the relationship between exposure to various BFRs and markers of liver function. To further explore the association between BFR exposure and liver function impairment, we used data from the National Health and Nutrition Examination Surveys (NHANES) for three cycles from 2009 to 2014, leaving 4206 participants (≥20 years of age) after screening.

Using the Pearson's correlation coefficient as the sole metric to measure the accuracy of quantitative trait prediction: is it sufficient?

How to evaluate the accuracy of quantitative trait prediction is crucial to choose the best model among several possible choices in plant breeding. Pearson's correlation coefficient (PCC), serving as a metric for quantifying the strength of the linear association between two variables, is widely used to evaluate the accuracy of the quantitative trait prediction models, and generally performs well in most circumstances. However, PCC may not always offer a comprehensive view of predictive accuracy, especially in cases involving nonlinear relationships or complex dependencies in machine learning-based methods.

Seasonal and spatial variability of dissolved organic nitrogen concentration and composition in Daya Bay, China.

Dissolved organic nitrogen (DON) has recently been recognized as an important nitrogen source for marine phytoplankton. However, the composition, sources, and biogeochemical cycling of DON in coastal ecosystems remain poorly understood. This study investigates the spatial distribution and seasonal variability of DON in Daya Bay, a subtropical semi-enclosed bay in the northern South China Sea.

Pathway and protein channel engineering of for improved production of desthiobiotin and biotin.

Biotin (vitamin B) is a crucial cofactor for various metabolic processes and has significant applications in pharmaceuticals, cosmetics, and animal feed. , a well-studied Gram-positive bacterium, presents a promising host for biotin production due to its Generally Recognized as Safe (GRAS) status, robust genetic tractability, and capacity for metabolite secretion. This study focuses on the metabolic engineering of .

A New Insight into the Mechanism of Atrazine-Induced Neurotoxicity: Triggering Neural Stem Cell Senescence by Activating the Integrated Stress Response Pathway.

Atrazine (AT), a widely utilized chemical herbicide, causes widespread contamination of agricultural water bodies. Recently, exposure to AT has been linked to the development of age-related neurodegenerative diseases (NDs), suggesting its neurotoxicity potential. As an endocrine disruptor, AT targets the hypothalamus, a crucial part of the neuroendocrine system.

Melatonin protects spermatogenic cells against DNA damage and necroptosis induced by atrazine.

Atrazine (ATZ), a widely used triazine herbicide, has been shown to disrupt reproductive development in organisms. Melatonin (MLT) is a natural hormone and has been shown to have strong antioxidant properties. Due to its lipophilicity, it can cross biological barriers freely and act on germ cells directly.

Temperature and plant-available soil phosphorus drive intraspecific variation in plant economic traits of Schima superba across an elevation gradient.

Background And Aims: The whole-plant economics spectrum (PES) describes coordination between organ-level traits that together determine resource use strategies and is relevant for understanding plant responses to environmental change. Whereas coordination between organs has previously been explored across species, it remains unclear whether patterns observed across species hold within species. In addition, the key driving forces underlying this coordination warrant clarification.

Parkin-TLR4-NLRP3 Axis Directs Melatonin to Alleviate Atrazine-Induced Immune Impairment in Splenic Macrophages.

Atrazine (ATR) is a widespread environmental herbicide that seriously affects agricultural work and human safety. Melatonin (MLT) as an endogenous neuroendocrine hormone is widely found in animals and plants, which have antioxidant and anti-inflammatory effects. Pink1/Parkin-mediated mitophagy keeps normal physiological processes by degrading damaged mitochondria in cells.

Leaf trait networks of subtropical woody plants weaken along an elevation gradient.

The leaf economic spectrum (LES) captures key leaf functional trait relationships, defining a conservative-acquisitive axis of plant resource utilization strategies. Examining the leaf trait network (LTN) is useful for understanding resource utilization strategies but also more broadly, the ecological strategies of plants. However, the relationship between the LES conservation-acquisition axis and LTN correlations across environmental gradients is unclear.

An Efficient and Stable Registration Framework for Large Point Clouds at Two Different Moments.

Point cloud registration plays a great role in many application scenarios; however, the registration of large-scale point clouds for actual different moments suffers from the problems of low efficiency, low accuracy, and a lack of stability. In this paper, we propose a registration framework for large-scale point clouds at different moments, which firstly downsamples large-scale point clouds using a random sampling method, then performs a random expansion strategy to make up for the loss of information caused by the random sampling, then completes the first registration by a deep learning network based on the extraction of keypoints and feature descriptors in combination with RANSAC, and finally completes the registration using the point-to-point ICP method. We conducted validation experiments and application experiments on large-scale point clouds of key train components, and the experimental results are much higher in accuracy or efficiency than other methods, which proves the effectiveness of our framework, which can be applied to actual large-scale point clouds.

Crystallization of Cathode Active Material Precursors from Tartaric Acid Solution.

In this study L-(+)-tartaric acid was used to extract metals from either pure cathode material (NMC111) or black mass from spent lithium-ion batteries. The leaching efficiencies of Li, Co, Ni, and Mn from NMC111 are >87 % at 70 °C, with an initial solid to liquid ratio of 17, and >72.4±1.

Effect of stress on study skills self-efficacy in Nursing students: the chain mediating role of general self-efficacy and self-directed learning.

Background: The purpose of the study is to explore the current level of nursing students' study skills self-efficacy, and whether general self-efficacy and self-directed learning ability mediate the relationship between perceived stress (including positive stress and negative stress) and study skills self-efficacy.

Methods: The survey was conducted among 1,289 nursing students including 795 students from Jinzhou Medical University and 494 students from Dalian University. Participants completed a self-designed questionnaire, which included the Study Skills Self-Efficacy Scale, Perceived Stress Scale, General Self-Efficacy Scale, Self-Directed Learning Instrument, gender, age, academic year, and other demographic characteristics.

Palladium-Mediated Bioorthogonal System for Prodrug Activation of -Benzylbenzamide-Containing Tubulin Polymerization Inhibitors for the Treatment of Solid Tumors.

Bioorthogonal cleavage reactions have been developed as an intriguing strategy to enhance the safety of chemotherapeutics. Aiming to reduce the toxicity and improve the targeted release properties of the colchicine binding site inhibitors (CBSIs) based on previous work, a series of biologically inert prodrugs were further designed and synthesized through a bioorthogonal prodrug strategy. The therapeutic effects of prodrugs could be "turned-on" once combined with palladium resins.

Dual frequency composite pattern temporal phase unwrapping for 3D surface measurement.

Phase shifting profilometry (PSP) is widely used in three-dimensional (3D) optical metrology applications such as mechanical engineering, industrial monitoring, computer vision, and biomedicine because of its high measurement accuracy. In PSP, multi-frequency temporal phase unwrapping (TPU) plays a dominant role due to its high-accuracy measurement of surfaces with discontinuities and isolated objects. However, it requires a large number of fringe patterns.

Lycopene mitigates atrazine-induced hypothalamic neural stem cell senescence by modulating the integrated stress response pathway.

Background: Atrazine, a widely used herbicide, has become a major pollutant in agricultural water bodies. Pesticide contamination, including atrazine, is linked to a high incidence of age-related neurodegenerative diseases, suggesting its neurotoxic potential. Lycopene, a potent antioxidant, is renowned for its diverse pharmacological effects, especially its neuroprotective properties.

AHR activation relieves deoxynivalenol-induced disruption of porcine intestinal epithelial barrier functions.

Mycotoxins are ubiquitous natural pollutants that pose a serious threat to public health. Deoxynivalenol (DON) as one of the most prominent mycotoxins has a noticeable adverse effect on intestinal barrier function, which depends on the intestinal barrier integrity. However, the potential mechanisms and effective therapeutic strategies remain unclear.

Increasing Vitamin K Synthesis in by Controlling the Expression of MenD and Stabilizing MenA.

As an indispensable member of the family of lipid vitamins, vitamin K (MK-7) plays an important role in blood coagulation, cardiovascular health, and kidney health. Microbial fermentation is favored due to its high utilization rate of raw materials, simple operation, and moderate conditions. However, the biosynthesis pathway of vitamin K in microorganisms is highly complex, which hinders its industrial production in microbial cell factories.

Effect of skeletal muscle index on post-embolization syndrome of hepatocellular carcinoma after transarterial chemoembolization.

Background: Skeletal muscle index (SMI) is a commonly used research method for evaluating muscle mass.However, its impact on post-embolization syndrome(PES) of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is unclear.Our objective was to determine the effect of SMI on PES after TACE in patients with HCC.