Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity.

Objectives: The white adipose tissue (WAT) expansion plays a significant role in the development of obesity. Cytoskeletal remodeling directly impacts adipogenic program, however, the precise mechanism remains poorly understood. Here, we identified a crucial role of Septin-7 (SEPT7), a cytoskeleton component, in the regulation of diet-induced processes of adipogenesis, lipogenesis, and lipolysis in WAT.

Validation of DNA methylation and transcriptional characteristics in CCL5 and CXCL8 genes in autoimmune thyroiditis with varying iodine levels.

AIT (autoimmune thyroiditis) is a complex disease influenced by genetic and environmental factors as well as immune dysregulation. Epigenetics has unveiled potential connections among environmental factors, gene expression and thyroid autoimmunity. Among epigenetic modifications, DNA methylation is the first discovered and the most extensively-studied.

Facilitating multiple nitrite for anammox process directly treating municipal wastewater: Optimized organics utilization and microbial composition.

While direct anammox implementation is attractive when treating wastewater, nitrite (NO-N) availability and excess organic matter significantly limit its practical application. This study proposed partial nitrification and endogenous partial denitrification/anammox (PN/A-EPD/A) for the treatment of real municipal wastewater (COD/N ratio: 2.8) within a single-stage reactor under anaerobic/aerobic/anoxic mode.

DNA methylation of genes that mediate autophagosome formation contributes to iodine-induced autoimmune thyroiditis: A population-based study conducted at regions with different iodine levels in China.

Purpose: Autoimmune thyroiditis (AIT) results from a combination of genetic predispositions and environmental factors. This study aims to examine the methylation patterns of genes that mediate autophagosome formation (MAF) between AIT patients and controls from areas with different water iodine levels.

Methods: A protein-protein interaction (PPI) network was constructed to explore the interactions of autophagy-related genes (ARGs).

Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.

Acute pancreatitis (AP) is a primary contributor to hospitalization and in-hospital mortality worldwide. Targeted elimination of mitochondrial reactive oxygen species (mtROS) within pancreatic acinar cells (PACs) represents an ideal strategy for treating AP. However, existing drugs fail to overcome the physiological barriers of the pancreas to effectively reach PACs mitochondria due to the trade-off between conventional positively charged mitochondrial-targeting groups and their inability to penetrate the blood-pancreas barrier (BPB).

Transcriptomic analysis reveals the hepatopancreas metabolic mechanisms of mud crab Scylla paramamosain fed diets with terrestrial animal fat sources replacing fish oil.

The transcriptome analysis following an 8-week feeding trial was employed to investigate the impacts of dietary terrestrial animal fats (TAFs includes lard oil (LO), beef tallow (BT) and poultry oil (PO)) replacing fish oil (FO) on the metabolic mechanism in hepatopancreas of mud crabs (Scylla paramamosain). The fatty acid (FA) transport, biosynthesis and lipid absorption and digestion were reduced through the regulation of PPAR pathway and the mRNA expressions of monoglyceride lipases (mgls), phosphatidate phosphatase-1 (pap1), acyl-sn-glycerol-3-phosphate acyltransferase delta (plcd), cAMP-dependent protein kinase catalytic (pkac), FA-binding protein 1 (fabp-1), FA transport protein 4 (fatp-4), short/branched chain specific acyl-CoA dehydrogenase (acdsb) and enoyl-CoA delta isomerase 2 (eci2), etc., after replacing FO with BT or LO.

COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines.

Two or more catalysts conducting multistep reactions in the same reactor, concurrent tandem catalysis, could enable (bio)pharmaceutical and fine chemical manufacturing to become much more sustainable. Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent organic framework capsule, COFcap-2, functions like an artificial cell in that, whereas the catalysts are trapped within 300-400 nm cavities, substrates/products can ingress/egress through ca. 2 nm windows.

STING1 targets MYH9 to drive adipogenesis through the AKT/GSK3β/β-catenin pathway.

Stimulator of interferon response cGAMP interactor 1 (STING1), as an innate immune adaptor protein that mediates DNA sensing, has attracted tremendous biomedical interest. However, several recent researches have revealed the key role of STING1 in regulating the metabolic pathway. Here, we investigated its role in adipocyte differentiation.

Kinetics Difference-driven Organophosphorus Hydrolase-like Nanozyme-Coded Pattern for Identifying -Nitrophenyl Pesticides.

Organophosphorus pesticides (OPs) are widely used in agricultural production, posing a great threat to human health and the environment. Given that different OPs present different toxicology and toxicities, identifying individual pesticide residues becomes important for assessing food safety and environmental implications. In this work, a kinetics difference-driven analyte hydrolysis strategy is proposed for the first time and validated to identify -nitrophenyl pesticides by developing an organophosphorus hydrolase-like nanozyme-coded sensor array.

Effect of trypsin digestion on the integrity and antigenic epitopes of GII.6 norovirus virus-like particles.

Trypsin digestion of the GII.6 norovirus (NoV) major capsid protein VP1 promotes its binding to histo-blood group antigens (HBGAs), which are believed to be co-receptors for NoVs. In our previous study, we found that trypsin digestion led to the disassembly of GII.

Clinical-Radiomics Nomogram Model Based on CT Angiography for Prediction of Intracranial Aneurysm Rupture: A Multicenter Study.

Objective: Risk estimation of intracranial aneurysm rupture is critical in determining treatment strategy. There is a scarcity of multicenter studies on the predictive power of clinical-radiomics models for aneurysm rupture. This study aims to develop a clinical-radiomics model and explore its additional value in the discrimination of aneurysm rupture.

Sterilization of image steganography using self-supervised convolutional neural network.

Background: With the development of steganography technology, lawbreakers can implement covert communication in social networks more easily, exacerbating network security risks. Sterilization of image steganography methods can eliminate secret messages to block the transmission of illegal covert communication. However, existing methods overly rely on cover-stego image pairs and are unable to sanitize unknown image, which reduces stego image blocking rate in social networks.

Hypercrosslinked Metal-Organic Polyhedra Electrolyte with High Transference Number and Fast Conduction of Li Ions.

Solid-state electrolytes (SSEs) with high Li-ion transference numbers and fast ionic conductivity are urgently needed for technological innovations in lithium-metal batteries. To promote the dissociation of ion pairs and overcome the mechanical brittleness and interface defects caused by traditional fillers in polymeric electrolytes, we designed and fabricated a cationic hypercrosslinking metal-organic polyhedra (HCMOPs) polymer as SSE. Benefiting a three-component synergistic effect: cationic MOPs, branched polyethyleneimine macromonomer and polyelectrolyte units, the Li-HCMOP electrolyte possesses a high Li-ion conductivity, a high Li-ion transference number and a low activation energy.

Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing.

Bacterial infection severely hinders skin wound healing, highlighting the critical application value of developing antibacterial and anti-inflammatory hydrogel dressings. In this work, we focused on β-glucan from Hericium erinaceus (HEBG) as the research object, and proposed a solvent-induced combined temperature manipulation technique to trigger multilevel self-assembly of β-glucan. Furthermore, we incorporated green synthesized near-infrared photosensitizer tannic acid (TA)/iron (III) complex into the system.

Association between risk factors and bone mineral density and the development of a self-assessment tool for early osteoporosis screening in postmenopausal women with type 2 diabetes.

Background: Both diabetes and osteoporosis have developed into major global public health problems due to the increasing aging population. It is crucial to screen populations at higher risk of developing osteoporosis for disease prevention and management in postmenopausal women with type 2 diabetes (T2D). This study aims to quantitatively investigate the association between risk factors and bone mineral density (BMD) and develop a self-assessment tool for early osteoporosis screening in postmenopausal women with T2D.

Feasibility of double nitrite supply through partial nitrification and partial denitrification driven by sludge fermentation.

Challenges in obtaining stable nitrite have impeded the use of anammox in municipal wastewater treatment. This study explored the feasibility of using sludge fermentation products as carbon source and selective nitrification inhibitor to supply nitrite via partial nitrification (PN) and partial denitrification (PD). PD was initiated within 15 days, achieving nitrite transformation rate of over 90 % with a carbon/nitrogen ratio of 3 and a reaction time of 0.

Novel control strategy employing anaerobic/aerobic/anoxic/aerobic/anoxic mode to enhance endogenous denitrification and anammox for municipal wastewater treatment.

Anaerobic/Aerobic/Anoxic (AOA) process utilizes endogenous denitrification to remove nitrogen. However, low endogenous denitrification activity critically restricts its application owing to insufficient carbon sources. In this study, a novel control strategy employing anaerobic/aerobic/anoxic/aerobic/anoxic (AOAOA) mode was introduced to treat low Carbon/Nitrogen (C/N) ratio municipal wastewater over 262 days.

Biological and immunological characterization of major capsid protein VP1 from distinct GII.2 norovirus clusters.

Human noroviruses (HuNoVs) are a leading cause of acute viral gastroenteritis worldwide. Infectious outbreaks due to recombinant NoV genotype called GII.P16-GII.

Advanced progress of the relationship between renin-angiotensin-aldosterone system inhibitors and cancers.

Hypertension and cancers are the most common causes of death in humans, as well as common co-diseases among elderly population. Studies have shown that hypertension is associated with carcinogenesis. The renin-angiotensin-aldosterone system (RAAS) is a crucial regulatory system of blood pressure, fluid, and electrolyte homeostasis, which plays an essential role in the pathogenesis of hypertension, whose mechanism is relatively clear.

Evidence for time-reversal symmetry-breaking kagome superconductivity.

Superconductivity and magnetism are often antagonistic in quantum matter, although their intertwining has long been considered in frustrated-lattice systems. Here we utilize scanning tunnelling microscopy and muon spin resonance to demonstrate time-reversal symmetry-breaking superconductivity in kagome metal Cs(V, Ta)Sb, where the Cooper pairing exhibits magnetism and is modulated by it. In the magnetic channel, we observe spontaneous internal magnetism in a fully gapped superconducting state.